
Clinical Biochemistry:Metabolic and Clinical Aspects
With Expert Consult access
- 3rd Edition - March 5, 2014
- Imprint: Churchill Livingstone
- Authors: William J. Marshall, Márta Lapsley, Andrew Day, Ruth Ayling
- Language: English
- Paperback ISBN:9 7 8 - 0 - 7 0 2 0 - 5 1 4 0 - 1
- eBook ISBN:9 7 8 - 0 - 7 0 2 0 - 5 7 1 8 - 2
- eBook ISBN:9 7 8 - 0 - 7 0 2 0 - 5 4 7 8 - 5
Now fully revised and updated, Clinical Biochemistry, third edition is essential reading for specialty trainees, particularly those preparing for postgraduate examinations. It… Read more

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Request a sales quoteNow fully revised and updated, Clinical Biochemistry, third edition is essential reading for specialty trainees, particularly those preparing for postgraduate examinations. It is also an invaluable current reference for all established practitioners, including both medical and scientist clinical biochemists.
Building on the success of previous editions, this leading textbook primarily focuses on clinical aspects of the subject, giving detailed coverage of all conditions where clinical biochemistry is used in diagnosis and management – including nutritional disorders, diabetes, inherited metabolic disease, metabolic bone disease, renal calculi and dyslipidaemias. The acquisition and interpretation of clinical biochemical data are also discussed in detail.
- From the author of the popular Clinical Chemistry medical student textbook
- there are many competing texts on clinical chemistry, the vast majority concentrate on the technology; this book concentrates on the clinical
- Ideally suited for preparation for the MRCPath and similar examinations
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Contributors
- CHAPTER 1 Uses of biochemical data in clinical medicine
- INTRODUCTION
- SPECIFIC USES OF BIOCHEMICAL TESTS
- CONCLUSION
- Further reading
- CHAPTER 2 Acquisition and interpretation of biochemical data
- INTRODUCTION
- THE TEST REQUEST
- FACTORS AFFECTING TEST RESULTS
- INTERPRETATION OF RESULTS
- THE PREDICTIVE VALUE OF TESTS
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 3 Quality aspects of laboratory medicine
- INTRODUCTION
- WHAT IS QUALITY?
- QUALITY STANDARDS
- CLINICAL QUALITY INDICATORS
- EVIDENCE-BASED CLINICAL BIOCHEMISTRY
- POINT-OF-CARE TESTING
- CONCLUSION
- FURTHER READING
- CHAPTER 4 Sodium, water and potassium
- PHYSIOLOGY
- DISORDERS OF SODIUM METABOLISM
- DISORDERS OF WATER METABOLISM
- DISORDERS OF POTASSIUM METABOLISM
- CONCLUSION
- Further reading
- APPENDIX 4.1 FORMULAE
- APPENDIX 4.2 DYNAMIC FUNCTION TESTS
- CHAPTER 5 Hydrogen ion homoeostasis and tissue oxygenation and their disorders
- INTRODUCTION
- THE PHYSIOLOGICAL ROLE OF HYDROGEN IONS
- HYDROGEN ION HOMOEOSTASIS
- THE ASSESSMENT OF ACID–BASE STATUS
- DISORDERS OF HYDROGEN ION HOMOEOSTASIS
- TISSUE OXYGENATION
- CONCLUSION
- Further reading
- CHAPTER 6 Calcium, phosphate and magnesium
- CALCIUM METABOLISM
- PHOSPHORUS METABOLISM
- MAGNESIUM METABOLISM
- CONCLUSION
- Further reading
- APPENDIX 6.1 CALCIUM ABSORPTION TEST
- APPENDIX 6.2 ANALYSIS OF TUBULAR HANDLING OF CALCIUM
- APPENDIX 6.3 CLASSIFICATION OF PSEUDOHYPOPARATHYROIDISM
- APPENDIX 6.4 ESTIMATION OF TMP/GFR
- APPENDIX 6.5 MAGNESIUM RETENTION TEST
- APPENDIX 6.6 RENAL TUBULAR REABSORPTION OF MAGNESIUM
- CHAPTER 7 The kidneys, renal function and kidney disease
- ANATOMY
- RENAL FUNCTION
- RENAL DISEASE AND ITS PRESENTATION
- THE ASSESSMENT OF RENAL FUNCTION
- ACUTE KIDNEY INJURY (ACUTE RENAL FAILURE)
- CHRONIC KIDNEY DISEASE
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 8 Proteinuria
- INTRODUCTION
- PROTEIN CONSERVATION BY THE KIDNEYS
- NORMAL URINARY PROTEIN CONTENT
- PROTEINURIA IN KIDNEY DISEASE
- MICROALBUMINURIA AS A MARKER OF RISK
- CLINICAL INVESTIGATION OF PROTEINURIA
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 9 Renal tubular disorders and renal stone disease
- INTRODUCTION
- RENAL TUBULAR DISORDERS
- RENAL CALCULI
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- APPENDIX 9.1 DIAGNOSIS OF RENAL TUBULAR ACIDOSIS
- CHAPTER 10 Clinical biochemistry of nutrition
- INTRODUCTION
- NUTRITIONAL REQUIREMENTS
- ASSESSMENT OF NUTRITIONAL STATUS
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 11 Nutritional disorders and their management
- INTRODUCTION
- MALNUTRITION
- OBESITY
- EATING DISORDERS
- DIET IN THE AETIOLOGY OF DISEASE
- THERAPEUTIC DIETS, DIETARY SUPPLEMENTS AND NUTRACEUTICALS
- PROVISION OF NUTRITION SUPPORT
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 12 Clinical biochemistry of the gastrointestinal tract
- INTRODUCTION
- MOUTH AND OESOPHAGUS
- STOMACH
- PANCREAS
- SMALL BOWEL BACTERIAL OVERGROWTH
- MALDIGESTION AND MALABSORPTION
- INTESTINAL PERMEABILITY
- FAECAL TESTS OF INTESTINAL INFLAMMATION
- THE ACUTE ABDOMEN
- Further reading
- CHAPTER 13 Assessment of hepatic function and investigation of jaundice
- INTRODUCTION
- ANATOMY OF THE LIVER
- HEPATIC REGENERATION
- PHYSIOLOGICAL FUNCTIONS
- LIVER FUNCTION TESTS
- USES OF LIVER FUNCTION TESTS
- ABNORMAL LIVER FUNCTION TESTS IN ASYMPTOMATIC PATIENTS
- NORMAL LIVER FUNCTION TESTS IN THE PRESENCE OF OVERT LIVER DISEASE
- ROLE OF LIVER FUNCTION TESTS IN ASSESSING PROGNOSIS
- CONCLUSION
- Further reading
- CHAPTER 14 Acute and chronic liver disease
- CLASSIFICATION OF LIVER DISEASE
- ACUTE HEPATITIS AND ITS SEQUELAE
- ACUTE LIVER FAILURE
- CHRONIC HEPATITIS
- PRIMARY BILIARY CIRRHOSIS (PBC)
- PRIMARY SCLEROSING CHOLANGITIS (PSC)
- ALCOHOLIC LIVER DISEASE
- THE CONCEPT OF CIRRHOSIS
- DRUGS AND THE LIVER
- NEOPLASTIC DISEASE OF THE LIVER AND BILIARY TRACT
- PARENTERAL NUTRITION
- BACTERIAL INFECTIONS
- INHERITED METABOLIC DISORDERS INVOLVING THE LIVER
- LIVER TRANSPLANTATION
- CONCLUSION
- Further reading
- CHAPTER 15 Glucose metabolism and the pathophysiology of diabetes mellitus
- PHYSIOLOGY AND PATHOPHYSIOLOGY OF GLUCOSE HOMOEOSTASIS
- CLASSIFICATION AND DIAGNOSIS OF DIABETES MELLITUS
- ENDOCRINE ASSOCIATIONS WITH DIABETES
- DIABETES, NUTRITION AND GROWTH
- MECHANISMS OF DIABETIC TISSUE DAMAGE
- CONDITIONS ASSOCIATED WITH INADEQUATELY CONTROLLED DIABETES MELLITUS
- BIOCHEMICAL MEASUREMENTS IN DIABETES MELLITUS
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 16 The clinical management of diabetes mellitus
- INTRODUCTION
- GENERAL ASPECTS OF MANAGEMENT
- GLUCOSE-LOWERING THERAPY IN DIABETES
- OBSTACLES TO ACHIEVING GLYCAEMIC CONTROL
- CHRONIC COMPLICATIONS OF DIABETES
- EMERGENCIES IN DIABETES
- MANAGEMENT OF DIABETES IN THE HOSPITAL SETTING
- PREGNANCY
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 17 Hypoglycaemia
- GLUCOSE HOMOEOSTASIS IN THE FED AND THE POSTABSORPTIVE STATES
- HYPOGLYCAEMIA
- CLASSIFICATION OF HYPOGLYCAEMIC DISORDERS
- PRACTICAL APPROACH TO THE INVESTIGATION OF HYPOGLYCAEMIA
- EMERGENCY TREATMENT OF HYPOGLYCAEMIA
- CAUSES OF HYPOGLYCAEMIA
- CONCLUSION
- Further reading
- CHAPTER 18 Hypothalamic, pituitary and adrenal disorders
- INTRODUCTION
- CLINICAL ANATOMY OF THE PITUITARY AND HYPOTHALAMUS
- PHYSIOLOGY OF HYPOTHALAMO– PITUITARY–END ORGAN AXES
- CLINICAL ANATOMY AND PHYSIOLOGY OF THE ADRENALS
- ASSESSMENT OF NORMAL PITUITARY FUNCTION
- OTHER DIAGNOSTIC TECHNIQUES IN PITUITARY DISEASE
- PITUITARY HYPERSECRETION STATES
- HYPOTHALAMIC AND PITUITARY DEFICIENCY STATES
- ADRENAL DISEASE
- MONITORING PITUITARY AND ADRENAL REPLACEMENT THERAPY
- CONCLUSION
- Further reading
- APPENDIX 18.1 TEST PROTOCOLS
- CHAPTER 19 Thyroid dysfunction
- INTRODUCTION
- NORMAL THYROID PHYSIOLOGY
- THE EVALUATION OF THYROID FUNCTION
- HYPERTHYROIDISM
- HYPOTHYROIDISM
- THYROIDITIS
- NEOPLASIA
- SYNDROMES OF RESISTANCE TO THYROID HORMONES
- SCREENING
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 20 Metabolic response to stress
- INTRODUCTION
- THE RESPONSE TO STRESS
- STRESS AND THE KIDNEYS
- CYTOKINES
- STRESS AND INFLAMMATION
- SHOCK
- CARE OF THE SHOCKED PATIENT
- CONCLUSION
- Further reading
- CHAPTER 21 Disorders of puberty and sex development
- INTRODUCTION
- NORMAL SEX DEVELOPMENT
- NORMAL PUBERTAL DEVELOPMENT
- DISORDERS OF SEX DEVELOPMENT
- DISORDERS OF PUBERTY
- Further reading
- CHAPTER 22 Reproductive function in the female
- INTRODUCTION
- PHYSIOLOGY
- HORMONES REGULATING REPRODUCTIVE FUNCTION
- REPRODUCTIVE STEROID HORMONES
- OLIGO- AND AMENORRHOEA
- INFERTILITY
- HIRSUTISM AND VIRILISM
- PREGNANCY
- ORAL CONTRACEPTION AND HORMONE REPLACEMENT THERAPY
- ACKNOWLEDGEMENT
- Further reading
- APPENDIX 22.1 ACTH STIMULATION TEST FOR THE DIAGNOSIS OF CONGENITAL ADRENAL HYPERPLASIA
- References
- CHAPTER 23 Reproductive function in the male
- INTRODUCTION
- THE TESTES
- EVALUATION OF TESTICULAR FUNCTION
- MALE HYPOGONADISM
- GYNAECOMASTIA
- IMPOTENCE
- Further reading
- APPENDIX 23.1 PROTOCOLS FOR ENDOCRINE INVESTIGATIONS
- Reference
- Reference
- Reference
- CHAPTER 24 Inherited metabolic disease
- INTRODUCTION
- CLINICAL PRESENTATION AND PATHOPHYSIOLOGY
- NEWBORN SCREENING
- INHERITANCE
- DIAGNOSTIC STRATEGIES
- PRENATAL DIAGNOSIS
- MANAGEMENT
- CONCLUSION
- Further reading
- CHAPTER 25 Paediatric clinical biochemistry
- INTRODUCTION
- POSTNATAL INVESTIGATION OF THE SMALL FOR GESTATIONAL AGE NEWBORN
- RESPIRATORY DISORDERS
- RENAL FUNCTION
- CARBOHYDRATE METABOLISM
- CALCIUM AND PHOSPHORUS METABOLISM
- DISORDERS OF LIVER FUNCTION
- Further reading
- CHAPTER 26 Introduction to haematology and transfusion science
- INTRODUCTION
- GENERAL HAEMATOLOGY
- MORPHOLOGY
- HAEMOSTASIS
- BLOOD TRANSFUSION
- CONCLUSION
- ACKNOWLEDGEMENTS
- Further reading
- CHAPTER 27 Biochemical aspects of anaemia
- INTRODUCTION
- THE FORMATION, STRUCTURE AND FUNCTION OF THE NORMAL RED CELL
- ANAEMIA
- ANAEMIAS ASSOCIATED WITH A REDUCTION IN RED CELL PRODUCTION
- ANAEMIAS ASSOCIATED WITH INCREASED RED CELL LOSS
- DIAGNOSIS OF HAEMOLYSIS
- CONCLUSION
- ACKNOWLEDGEMENTS
- Further reading
- CHAPTER 28 The porphyrias: inherited disorders of haem synthesis
- INTRODUCTION AND OVERVIEW
- PORPHYRIAS PRESENTING WITH ACUTE ATTACKS
- THE CUTANEOUS PORPHYRIAS
- SECONDARY DISORDERS OF PORPHYRIN METABOLISM
- CONCLUSION
- CHAPTER 29 The haemoglobinopathies
- INTRODUCTION
- THE THALASSAEMIAS
- STRUCTURAL HAEMOGLOBIN VARIANTS
- LABORATORY DIAGNOSIS OF HAEMOGLOBINOPATHIES
- CONCLUSION
- Further reading
- CHAPTER 30 Immunology for clinical biochemists
- THE IMMUNE SYSTEM
- DISEASES OF THE IMMUNE SYSTEM
- LYMPHOID MALIGNANCIES
- INFECTION AND SEPSIS
- TRANSPLANTATION
- CONCLUSION
- Further reading
- APPENDIX 30.1 IMMUNOLOGICAL INVESTIGATIONS
- CHAPTER 31 Metabolic bone disease
- BONE BIOLOGY
- OSTEOPOROSIS
- OSTEOMALACIA
- CHRONIC KIDNEY DISEASE – MINERAL AND BONE DISORDER
- BONE DISEASE IN PRIMARY HYPERPARATHYROIDISM
- PAGET DISEASE OF BONE
- BONE TURNOVER AND BONE DISEASE IN CHILDREN
- GENETIC BONE DISEASES
- CONCLUSION
- Further reading
- APPENDIX 31.1 INDICATIONS FOR DIAGNOSTIC TRANSILIAC BONE BIOPSY
- APPENDIX 31.2 PROTOCOL FOR DESFERRIOXAMINE TEST IN DIALYSIS PATIENTS
- CHAPTER 32 Biochemistry of articular disorders
- INTRODUCTION
- THE ARTICULAR SYSTEM
- DISORDERS OF THE ARTICULAR SYSTEM
- ARTICULAR INVOLVEMENT IN ENDOCRINE AND METABOLIC DISEASES
- LABORATORY TESTING IN ARTICULAR DISEASE
- CONCLUSION
- Further reading
- CHAPTER 33 Muscle disease
- INTRODUCTION
- FUNCTIONAL ANATOMY AND PHYSIOLOGY OF MUSCLE
- DISEASES OF MUSCLE AND THEIR INVESTIGATION
- BIOCHEMICAL INVESTIGATION OF MUSCLE DISEASE
- INVESTIGATION OF MUSCLE DISEASE
- CONCLUSION
- ACKNOWLEDGEMENTS
- Further reading
- APPENDIX 33.1 THE FOREARM EXERCISE TEST
- CHAPTER 34 Investigation of cerebrospinal fluid
- INTRODUCTION
- CEREBROSPINAL FLUID PHYSIOLOGY
- INVESTIGATIONS RELEVANT TO PHYSIOLOGY AND PATHOPHYSIOLOGY
- BIOCHEMICAL INVESTIGATIONS IN CNS DISORDERS
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 35 Biochemical aspects of psychiatric disorders
- INTRODUCTION: PSYCHIATRY AS A CLINICAL DISCIPLINE
- THE CLASSIFICATION OF PSYCHIATRIC DISORDERS
- THE AETIOLOGY OF PSYCHIATRIC DISORDERS
- BIOCHEMICAL INVESTIGATIONS IN PSYCHIATRIC DISORDERS
- PSYCHIATRIC MANIFESTATIONS OF ORGANIC DISEASE
- ENDOCRINE AND METABOLIC MANIFESTATIONS OF PSYCHIATRIC DISEASE
- METABOLIC COMPLICATIONS OF PSYCHOTROPIC DRUGS
- FUTURE DEVELOPMENTS
- CONCLUSION
- Further reading
- CHAPTER 36 Biochemical aspects of neurological disease
- INTRODUCTION
- ENCEPHALOPATHY
- SPINAL CORD DISORDERS
- PERIPHERAL NEUROPATHY
- MOVEMENT DISORDERS
- ATAXIA
- INFLAMMATORY DISORDERS OF THE CENTRAL NERVOUS SYSTEM
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 37 Lipids and disorders of lipoprotein metabolism
- INTRODUCTION
- LIPIDS
- LIPOPROTEINS
- APOLIPOPROTEINS
- CHOLESTEROL ABSORPTION
- TRIGLYCERIDE DIGESTION
- BILE ACID METABOLISM
- LIPOPROTEIN METABOLISM
- ENZYMES INVOLVED IN LIPOPROTEIN METABOLISM
- TRANSFER PROTEINS INVOLVED IN LIPOPROTEIN METABOLISM
- RECEPTORS INVOLVED IN LIPOPROTEIN METABOLISM
- OTHER PROTEINS INVOLVED IN LIPOPROTEIN SYNTHESIS, TRANSPORT AND METABOLISM
- CLASSIFICATION OF LIPOPROTEIN DISORDERS
- THE PRIMARY DYSLIPOPROTEINAEMIAS
- ACQUIRED HYPERLIPIDAEMIAS
- ACQUIRED HYPOLIPIDAEMIA
- INVESTIGATION OF LIPID DISORDERS
- TREATMENT OF HYPERLIPIDAEMIA
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- CHAPTER 38 Clinical biochemistry of the cardiovascular system
- INTRODUCTION
- CARDIAC MUSCLE STRUCTURE AND BIOCHEMISTRY
- ARTERIAL STRUCTURE AND FUNCTION
- ATHEROSCLEROSIS
- ACUTE MYOCARDIAL DAMAGE
- HEART FAILURE
- CARDIOVASCULAR RISK FACTORS
- HYPERTENSION
- CONCLUSION
- Further reading
- APPENDIX 1 PROTOCOL FOR INVESTIGATION OF ALDOSTERONISM: SCREENING AND CONFIRMATORY TESTS
- CHAPTER 39 Therapeutic drug monitoring
- INTRODUCTION
- USE OF THERAPEUTIC DRUG MONITORING
- PROVISION OF A THERAPEUTIC DRUG MONITORING SERVICE
- PHARMACODYNAMIC MONITORING, BIOMARKERS AND PHARMACOGENETICS
- INDIVIDUAL DRUGS
- ACKNOWLEDGEMENT
- Further reading
- APPENDIX 39.1 CALCULATIONS FOR THE DETERMINATION OF DOSE REQUIREMENTS TO ACHIEVE STEADY-STATE CONCENTRATIONS
- CHAPTER 40 Poisoning
- INTRODUCTION
- AETIOLOGY OF POISONING
- TYPES OF LESION IN POISONING
- DIAGNOSIS AND MANAGEMENT OF POISONING: GENERAL PRINCIPLES
- SPECIFIC POISONS
- CONCLUSION
- ACKNOWLEDGEMENT
- Further reading
- APPENDIX 40.1 POISONS CENTRES
- CHAPTER 41 Metabolic effects of tumours
- INTRODUCTION
- NEUROENDOCRINE TUMOURS
- MULTIPLE ENDOCRINE NEOPLASIA
- METABOLIC CHANGES IN MALIGNANCY
- ENDOCRINE SEQUELAE OF TUMOURS AND THEIR TREATMENT
- CONCLUSION
- Further reading
- CHAPTER 42 Tumour markers
- INTRODUCTION
- TUMOUR MARKERS IN THE MANAGEMENT OF SPECIFIC CANCERS
- SUMMARY
- Further reading
- CHAPTER 43 Molecular clinical biochemistry
- INTRODUCTION
- GENES AND GENE EXPRESSION
- THE TECHNIQUES OF GENETIC ANALYSIS
- THE APPLICATIONS OF DNA ANALYSIS
- GENE THERAPY
- CONCLUSION
- ACKNOWLEDGEMENTS
- Further reading
- CHAPTER 44 Forensic biochemistry
- INTRODUCTION
- SAMPLES AND SAMPLING
- POISONING WITH ENDOGENOUS AGENTS
- POST-MORTEM BIOCHEMISTRY
- SPECIFIC DIAGNOSTIC PROBLEMS
- Further reading
- Index
- Edition: 3
- Published: March 5, 2014
- Imprint: Churchill Livingstone
- No. of pages: 996
- Language: English
- Paperback ISBN: 9780702051401
- eBook ISBN: 9780702057182
- eBook ISBN: 9780702054785
WM
William J. Marshall
ML
Márta Lapsley
AD
Andrew Day
RA