Clinical Aspects of Multiple Sclerosis Essentials and Current Updates
- 1st Edition - January 13, 2024
- Editors: Shitiz Sriwastava, Evanthia Bernitsas
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 3 4 3 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 3 4 2 - 9
Clinical Aspects of Multiple Sclerosis Essentials and Current Updates offers readers a comprehensive and up-to-date analysis of multiple sclerosis (MS) and its related disorders,… Read more
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Request a sales quote- Explores the practical applications of optical coherence tomography (OCT) and OCT angiography (OCTA) in assessing MS.
- Delves into utilizing advanced imaging modalities and corresponding radiological findings for the diagnosis and monitoring.
- Includes cutting-edge technologies: 7 Tesla (7T) magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), positron emission tomography (PET), and magnetic resonance spectroscopy (MR spectroscopy).
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Acknowledgment
- Chapter 1. Introduction to multiple sclerosis: Subtypes, pathogenesis, and diagnostic criteria
- Introduction
- Multiple sclerosis: epidemiology
- Multiple sclerosis: histological classification
- Multiple sclerosis: clinical classification
- Multiple sclerosis: diagnostic criteria
- Multiple sclerosis: new formalized terms—CIS and RIS
- Conflict of interest statement
- Chapter 2. An overview of neuromyelitis optica spectrum disorders
- Overview and epidemiology
- Pathophysiology
- Clinical presentation
- Histopathological findings
- Radiological findings
- Diagnosis
- Management
- Conflict of interest statement
- Chapter 3. Epidemiology, epigenetics, and etiological factors in multiple sclerosis
- Prevalence and geography
- Demographics
- Genetics
- Genome wide association studies
- Interleukin 7 receptor alpha, interleukin 2 receptor alpha
- Human leukocyte antigen genes
- Epigenetics
- Environmental risk factors
- Epstein–Barr virus
- Human endogenous retrovirus type W
- Cytomegalovirus
- Human herpesvirus 6
- UVB and latitude
- Vitamin D
- Smoking
- Obesity
- Dietary salt intake
- Microbiome
- Conflict of interest statement
- Chapter 4. Beyond MS: Other demyelinating disorders and common mimickers
- Introduction
- Neuromyelitis optica spectrum disorder
- Myelin oligodendrocyte glycoprotein antibody-associated disease
- Sarcoidosis
- Systemic lupus erythematosus
- Sjögren's syndrome
- Vitamin B12 deficiency
- Adult-onset leukodystrophies
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
- Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids
- Behçet's disease
- Susac syndrome
- Leber hereditary optic neuropathy
- CNS vasculitis
- Chapter 5. Disease-modifying therapies: Current landscape and emerging approaches
- Treatment strategies
- Disease-modifying therapies
- Emerging therapies
- Stem cells therapies
- Treatment failure
- When to start
- When to switch
- When to discontinue
- Escalation versus early intense therapy for multiple sclerosis
- Treatment of clinically and radiologically isolated syndrome
- COVID and DMT
- Conflict of interest statement
- Chapter 6. Treatment guidelines and considerations for pediatric multiple sclerosis
- Epidemiology
- Risk factors
- Pathophysiology
- Diagnostic criteria
- Clinical presentation
- Cognitive impairment
- Alternate diagnosis and mimics
- Diagnostic evaluation
- MRI findings
- Treatment approach
- Acute treatment
- Disease modifying agents
- Chapter 7. Multiple sclerosis and pregnancy management: From preconception to postpartum
- Introduction
- Prepregnancy, pregnancy, and postpregnancy planning in patients with MS
- Treatment of MS relapses during pregnancy and breastfeeding
- Effects of breastfeeding on MS
- Role of vitamin D in preventing postpartum relapse of MS
- Best practice recommendations—disease-modifying therapies for pregnant women who have multiple sclerosis
- Best practice recommendations: Disease-modifying therapies and lactation in women with MS
- Conclusion
- Chapter 8. Rare variant of multiple sclerosis
- Introduction
- Tumefactive MS
- Balo's concentric sclerosis
- Schilder's disease
- Marburg MS
- Conflict of interest statement
- Chapter 9. Neuroimaging in multiple sclerosis and related disorders: Advancements and concepts
- Imaging protocols: brain, cervical and thoracic cord, and orbit
- Imaging findings of brain, spinal cord, and orbits in MS
- MS variants and differential diagnosis
- Newer imaging studies in multiple sclerosis
- Chapter 10. Optical coherence tomography in multiple sclerosis: Diagnostic applications
- Introduction
- Role of OCT in multiple sclerosis
- OCT angiography
- Chapter 11. Cognitive impairment in multiple sclerosis
- Definition
- Epidemiology
- Cognitive functions and cognitive reserve
- Structural and imaging findings
- Diagnosis and differential diagnosis
- Treatment
- Impact
- Index
- No. of pages: 402
- Language: English
- Edition: 1
- Published: January 13, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780323953436
- eBook ISBN: 9780323953429
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Shitiz Sriwastava
Dr. Shitiz K. Sriwastava, MD, is an Assistant Professor in the Department of Neurology with the Division of Multiple Sclerosis and Neuroimmunology at the University of Texas Health Science Center – Houston (UTHealth). He is a board-certified neurologist specialized in multiple sclerosis (MS). During his fellowship training and residency at Wayne State, he performed clinical research on MS and related autoimmune disorders of the central nervous system. He has had many years of experience in MS related clinical trials as a fellow or co-investigator. Dr. Sriwastava has a keen interest in identifying prognostic markers to predict the initiation and progression of MS especially early neurogenerative changes and also DTI studies in MS. He is currently a member of the American Academy of Neurology. His clinical, basic and translational studies in neuroimmunologic diseases have resulted in 50 peer reviewed papers and reports, published abstracts from national and international meetings.
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Evanthia Bernitsas
Evanthia Triantafylou-Bernitsas, MD, joined the Department of Neurology at Wayne State University in 2011. She has completed a neurology residency at Case Western Reserve University and Neuroimmunology Fellowships at the University of Michigan and Baylor College of Medicine. She is the Director of the Multiple Sclerosis Center at Wayne State School of Medicine and Professor of Neurology. Her clinical research focuses on aggressive forms of MS, new immunomodulatory therapies and symptomatic interventions. Dr. Bernitsas directs a very active clinical research program and she is the principal investigator on numerous clinical and investigator-initiated trials. Currently, she serves as the Editor-in Chief in the Neuroimaging section of the Brain Sciences journal. She has published extensively and served in several committees and advisory boards.