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Circadian System
- 1st Edition, Volume 137 - September 11, 2023
- Editor: Rossen Donev
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 1 8 3 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 1 8 4 - 4
Circadian System, Volume 137 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting inter… Read more
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Request a sales quoteCircadian System, Volume 137 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters that comprehensively cover Circadian Systems Genes and Their Importance for Human Health, Single nucleotide polymorphisms (SNPs) in circadian genes: Impact on Gene Function and Phenotype, Relationship between circadian rhythm and diseases: sex hormones impact, Advances in circadian clock regulation of reproduction, Disruption of the clock gene expression in central and peripheral circadian oscillators by maternal overnutrition in the Oryctolagus cuniculus, COVID-19 disease management in aspect of Circadian system, and more.
Other sections cover Molecular Characterization of Circadian Gene Expression and Its Correlation with Survival Percentage in Colorectal Cancer Patients, Identifying circadian gene signature that estimates overall survival from colon adenocarcinoma, The role of environmental signals in the expression of rhythmic cardiac proteins and their influence on cardiac pathologies, and much more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Advances in Protein Chemistry and Structural Biology series
- Updated release includes the latest information on the Circadian System
Researchers and students
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: The circadian systems genes and their importance of human health
- Abstract
- 1 Introduction
- 2 Circadian rhythm mechanism
- 3 Clock genes
- 4 Circadian genes and human health
- 5 Conclusion
- References
- Chapter Two: Single nucleotide polymorphisms (SNPs) in circadian genes: Impact on gene function and phenotype
- Abstract
- 1 Introduction
- 2 The association of pathogenic circadian core clock gene variations with human diseases
- 3 The association of single nucleotide polymorphisms (SNPs) with human diseases
- 4 Conclusion
- Acknowledgment
- References
- Chapter Three: The impact of biological clock and sex hormones on the risk of disease
- Abstract
- 1 Introduction
- 2 The circadian system
- 3 Molecular clock mechanism
- 4 Hormones regulate the circadian clocks
- 5 Sex hormones regulate circadian clock mechanisms
- 6 Disease, sex hormones and the molecular clock
- 7 Conclusion
- References
- Chapter Four: Advances in circadian clock regulation of reproduction
- Abstract
- 1 Introduction
- 2 The circadian clock system
- 3 The roles of the circadian clock system in the HPG axis and reproductive tissues
- 4 The effect of chronodisruption on reproductive performance
- 5 Therapeutic strategies for preventing the negative effects of chronodisruption on reproduction
- 6 Conclusion
- References
- Further reading
- Chapter Five: Circadian rhythms and cancer
- Abstract
- 1 Introduction
- 2 Characteristics of circadian rhythms
- 3 Factors that disrupt normal circadian rhythms
- 4 Impact of genome
- 5 DNA repair mechanism
- 6 Deregulating cellular metabolism
- 7 Role of the circadian clock in cancer
- 8 Role of the circadian clock in the cancer immunity cycle
- 9 Circadian clock affects lymphocyte trafficking and infiltration in cancer
- 10 Components regulate the recognition and elimination of cancer cells
- 11 Factors influencing the CR in cancer cells
- 12 Mechanisms linking clock dysfunction to the hallmarks of cancer
- 13 Regulation of cancer cell signalling
- 14 Clock influence on cell death
- 15 Clock genes in various cancers
- 16 Clock drugs for cancer therapy
- 17 Conclusions and future directions
- References
- Chapter Six: Molecular characterization of circadian gene expression and its correlation with survival percentage in colorectal cancer patients
- Abstract
- Abbreviations
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Discussion
- 5 Conclusion
- References
- Chapter Seven: Identification of potential circadian genes and associated pathways in colorectal cancer progression and prognosis using microarray gene expression analysis
- Abstract
- 1 Introduction
- 2 Materials and methods
- 3 Results and Discussion
- 4 Functional enrichment analysis
- 5 Conclusion
- Acknowledgment
- References
- Chapter Eight: The role of environmental signals in the expression of rhythmic cardiac proteins and their influence on cardiac pathologies
- Abstract
- 1 Introduction
- 2 Diet as a modulator of cardiac protein expression
- 3 Light as a modulator of cardiac protein expression
- References
- Chapter Nine: Circadian system microRNAs – Role in the development of cardiovascular diseases
- Abstract
- 1 Introduction
- 2 MicroRNA
- 3 Role of microRNA in cardiovascular diseases
- 4 Role of microRNA in circadian rhythm
- 5 Circadian microRNA in cardiovascular diseases
- 6 MicroRNA as diagnostics biomarkers for cardiovascular diseases
- 7 Treatment with miRNA
- 8 Conclusion
- References
- Chapter Ten: The circadian system and mood related behavior in mice
- Abstract
- 1 Introduction
- 2 The circadian clock mechanism and its inputs and outputs related to mood
- 3 Genetic alteration of clock genes and mood related behaviors
- 4 Factors that modulate mood via clock components
- 5 Conclusions
- Acknowledgments
- References
- Chapter Eleven: The interplay between circadian clock and viral infections: A molecular perspective
- Abstract
- 1 Introduction
- 2 Impact of host circadian pathways on viral infections
- 3 Impact of viral infections upon host circadian clock
- 4 Viral manipulation of the circadian clock epigenetic regulation
- 5 Chronotherapeutic interventions for viral infections
- 6 Future challenges in chronobiology research
- 7 Summary
- References
- No. of pages: 330
- Language: English
- Edition: 1
- Volume: 137
- Published: September 11, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443131837
- eBook ISBN: 9780443131844
RD
Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.
Affiliations and expertise
Head of Research, MicroPharm Limited, UKRead Circadian System on ScienceDirect