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Cilia Signaling in Development and Disease
- 1st Edition, Volume 155 - November 27, 2023
- Editors: Carlo Iomini, Yang Sun
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 1 5 9 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 1 6 6 - 4
Cilia Signaling in Development and Disease, Volume 155 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presen… Read more
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Request a sales quoteCilia Signaling in Development and Disease, Volume 155 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Cilia and mTOR signaling, Cilia and Kidney, Extraciliary functions of IFT proteins, Cilia and eye stem cells, Cilia and eye development, Cryo-EM/ET and cilia structure, and Control of protein and lipid composition of photoreceptor outer segments and the implications for eye diseases.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Current Topics in Developmental Biology series
- Updated release includes the latest information on Cilia Signaling in Development and Disease
Scientists and researchers
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Chapter One: Crosstalk between the mTOR pathway and primary cilia in human diseases
- Abstract
- 1 Introduction
- 2 Structure of mTOR
- 3 Nutrient sensing mTOR signaling pathways
- 4 Primary cilia overview
- 5 Crosstalk between mTOR and Cilia
- 6 Role of mTOR and cilia signaling in kidney disease
- 7 Role of mTOR and cilia in brain development and diseases
- 8 mTOR and cilia in eye development and disease
- 9 Conclusion
- References
- Chapter Two: Functions of the primary cilium in the kidney and its connection with renal diseases
- Abstract
- 1 Introduction
- 2 Ciliopathies
- 3 The primary cilium, the transition zone, and the formation of a specialized compartment
- 4 Ciliogenesis
- 5 Emergence of the primary cilium as a clinically important structure
- 6 Cilia and cell cycle regulation
- 7 Cilia regulation of signaling activity
- 8 Cilia and mechanosensation
- 9 Polycystic kidney diseases
- 10 Conclusion
- References
- Chapter Three: The complex relationship of Wnt-signaling pathways and cilia
- Abstract
- 1 Introduction
- 2 Relationship of cilia and canonical Wnt/β-catenin signaling
- 3 Wnt–LRP6 signaling via the destruction complex/GSK3β promotes ciliary biogenesis
- 4 Wnt/Frizzled–PCP signaling regulates ciliary positioning and also centriole positioning in non-ciliated cells
- 5 Conclusions
- Acknowledgments
- References
- Chapter Four: Patient stem cell-derived in vitro disease models for developing novel therapies of retinal ciliopathies
- Abstract
- 1 Introduction
- 2 Structure of primary cilium
- 3 Photoreceptor outer segment as a specialized primary cilium
- 4 Retinal ciliopathies and their underlying gene mutations
- 5 Model systems to study ciliopathies
- 6 Methods for differentiation of retinal cells from human iPSCs
- 7 Characterization and staging of iPSC-derived retinal cells
- 8 Limitations of current methods
- 9 Mechanisms of human retinal ciliopathies using patient-derived cells
- 10 Approaches for treatment of retinal ciliopathies
- 11 Challenges in developing therapies using existing modalities
- 12 Conclusions and future outlook
- Acknowledgments
- References
- Chapter Five: Control of protein and lipid composition of photoreceptor outer segments—Implications for retinal disease
- Abstract
- Abbreviations
- 1 Opening remarks
- 2 Part I: Overview of retinal function and disease—Placing the photoreceptor cilium into context
- 3 Part II. The many ways to disrupt outer segment structure and/or composition and their consequences for human vision
- 4 Summary and open questions
- References
- No. of pages: 362
- Language: English
- Edition: 1
- Volume: 155
- Published: November 27, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780128201596
- eBook ISBN: 9780128201664
CI
Carlo Iomini
Carlo Iomini, Assistant Professor, Johns Hopkins School of Medicine, MD, USA
Affiliations and expertise
Assistant Professor, Johns Hopkins School of Medicine, MD, USAYS
Yang Sun
Dr. Yang Sun works as an Associate Professor of Ophthalmology at Stanford University School of Medicine, California, USA.
Affiliations and expertise
Stanford University School of Medicine, CA, USARead Cilia Signaling in Development and Disease on ScienceDirect