Chloride Movements Across Cellular Membranes
- 1st Edition, Volume 38 - January 8, 2007
- Latest edition
- Editor: Michael Pusch
- Language: English
All living cells are surrounded by a lipidic membrane that isolates them from the often harsh environment. However, to take up nutrients, to excrete waste, and to communicate among… Read more
All living cells are surrounded by a lipidic membrane that isolates them from the often harsh environment. However, to take up nutrients, to excrete waste, and to communicate among each other, Nature has invented an incredibly diverse set of transmembrane transport proteins. Specialized transporters exist to shuttle electrically charged ions, positive cations like sodium or negative anions like chloride, across the membrane. In the recent years, tremendous progress has been made in the field of chloride transport. The present book presents the state of the art of this rapidly expanding and interest-gaining field of membrane transport. It is addressed at a broad medically, physiologically, biologically, and biophysically interested readership.
- Describes the state-of-the-art in anion transport research
- Written by leaders in the field
- Presents a timely discussion of this rapidly emerging and expanding field
Neuroscientists, physiologists, pediatricians, membrane biophysicists, nephrologists, neurologists, structural biologists.
- Contributors to Volume 38
- Preface
- Chapter 1: Chloride–Transporting Proteins in Mammalian Organisms: An Overview
- Chapter 2: Physiological Functions of the CLC Chloride Transport Proteins
- I INTRODUCTION
- II PHYSIOLOGICAL FUNCTION OF CLC–0 AND MAMMALIAN CLC PROTEINS
- III CLC PROTEINS IN MODEL ORGANISMS
- IV SUMMARY AND OUTLOOK
- Chapter 3: Structure and Function of CLC Chloride Channels and Transporters
- I THE STRUCTURE OF CLC–EC1, A BACTERIAL CLC TRANSPORTER
- II STRUCTURAL CONSERVATION AMONG THE CLCS
- III ION SELECTIVITY, PERMEATION AND BINDING
- IV A MULTI–ION PORE
- V CHANNELS AND TRANSPORTERS: WHERE IS THE DIFFERENCE?
- VI FUNCTION OF THE CLC TRANSPORTERS
- VII SPECULATIVE MODELING
- VIII CLC CHANNEL GATING
- IX THE ROLE OF THE C–TERMINAL DOMAIN OF CLC CHANNELS: RECENT DEVELOPMENTS
- X CONCLUSIONS AND OUTLOOK
- ACKNOWLEDGMENTS
- Chapter 4: Pharmacology of CLC Chloride Channels and Transporters
- I INTRODUCTION
- II THE PHARMACOLOGY OF THE MACROSCOPIC SKELETAL MUSCLE Cl− CONDUCTANCE gCl
- III NEW MOLECULES TARGETING ClC-1 IDENTIFIED USING HETEROLOGOUS EXPRESSION
- IV MECHANISM OF BLOCK OF MUSCLE TYPE CLC CHANNELS BY CLOFIBRIC ACID DERIVATIVES
- V THE BINDING SITE FOR 9-AC AND CPA ON ClC-1 AND ClC-0 AND USE OF CPA AS A TOOL TO EXPLORE THE MECHANISMS OF GATING OF ClC-0
- VI PHARMACOLOGY OF CLC-K CHANNELS
- VII OTHER CLC CHANNELS AND OTHER BLOCKERS
- VIII POTENTIAL OF HAVING BLOCKERS OF ClC-2, ClC-3, ClC-5, ClC-7: OUTLOOK
- ACKNOWLEDGMENTS
- Chapter 5: The Physiology and Pharmacology of the CFTR Cl− Channel
- I INTRODUCTION
- II THE MOLECULAR PHYSIOLOGY OF CFTR
- III THE CELLULAR PHYSIOLOGY OF CFTR
- IV THE ROLE OF CFTR IN EPITHELIAL PHYSIOLOGY
- V THE PATHOPHYSIOLOGY OF CFTR
- VI THE PHARMACOLOGY OF CFTR
- VII CONCLUSIONS
- ACKNOWLEDGMENTS
- Chapter 6: Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel
- I CFTR OVERVIEW
- II REGULATION OF CFTR BY PHOSPHORYLATION/DEPHOSPHORYLATION
- III CFTR IS AN ATPASE
- IV STRUCTURAL BIOLOGY OF ABC TRANSPORTERS
- V METHODS USED TO STUDY CFTR GATING
- VI CFTR GATING BY ATP
- VII UNSETTLED ISSUES AND FUTURE DIRECTIONS
- ACKNOWLEDGMENTS
- Chapter 7: Functional Properties of Ca2+–Dependent Cl− Channels and Bestrophins: Do They Correlate?
- I SUMMARY
- II INTRODUCTION
- III FUNCTIONAL PROPERTIES OF CaCCs
- IV MOLECULAR CANDIDATES OF CaCCs
- V FUNCTIONAL PROPERTIES OF BESTROPHINS
- VI CONCLUDING REMARKS
- ACKNOWLEDGMENTS
- Chapter 8: Cell Volume Homeostasis: The Role of Volume–Sensitive Chloride Channels
- I INTRODUCTION
- II CELL VOLUME HOMEOSTASIS
- III VOLUME–SENSITIVE Cl− CHANNELS
- IV CONCLUDING REMARKS
- Chapter 9: GABAergic Synaptic Transmission
- I POSTSYNAPTIC GABA RESPONSES
- II MOLECULAR COMPOSITION AND FUNCTION OF GABAERGIC/GLYCINERGIC SYNAPSES
- III MODULATION OF SYNAPTIC FUNCTIONS THROUGH ENDOGENOUS SUBSTANCES AND DRUGS
- IV PERSPECTIVE: SPECIFICITY OF GABAERGIC AND GLYCINERGIC SIGNALING IN DEFINED NETWORKS
- Chapter 10: Physiology of Cation–Chloride Cotransporters
- I INTRODUCTION
- II THE CATION–CHLORIDE COTRANSPORTER FAMILY
- III CATION–CHLORIDE COTRANSPORTERS IN THE NERVOUS SYSTEM
- IV CATION–CHLORIDE COTRANSPORTERS IN THE INNER EAR
- V CATION–CHLORIDE COTRANSPORTERS IN THE KIDNEY
- VI CATION–CHLORIDE COTRANSPORTERS IN RBCs
- VII CATION–CHLORIDE COTRANSPORTER AND CANCER
- VIII CATION–CHLORIDE COTRANSPORT AND HYPERTENSION
- IX CONCLUDING REMARKS
- Chapter 11: Plasma Membrane Cl−/HCO3− Exchange Proteins
- I INTRODUCTION
- II THE Cl−/HCO3− EXCHANGERS
- III DISPUTED Cl−/HCO3− EXCHANGERS
- IV STRUCTURE
- V REGULATION AND INHIBITION OF Cl−/HCO3− EXCHANGE
- VI PATHOPHYSIOLOGY
- ACKNOWLEDGMENTS
- Chapter 12: Orchestration of Vectorial Chloride Transport by Epithelia
- I INTRODUCTION
- II EPITHELIAL CELL STRUCTURE AND ORGANIZATION
- III JUNCTIONAL PROTEINS: AN OVERVIEW
- IV CHLORIDE TRANSPORTING PROTEINS IN EPITHELIA: CHANNELS, TRANSPORTERS, AND ALL THINGS IN BETWEEN
- V PDZ PROTEINS: WHAT ARE THEY? WHERE ARE THEY? WHAT DO THEY DO?
- VI TWO DISEASES INVOLVING EPITHELIAL CHLORIDE TRANSPORT
- VII SUMMARY
- Index
- Edition: 1
- Latest edition
- Volume: 38
- Published: January 8, 2007
- Language: English
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