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Chitosan in Biomedical Applications

1st Edition - December 1, 2021

Editors: Md Saquib Hasnain, Sarwar Beg, Amit Kumar Nayak

Paperback ISBN:

9 7 8 - 0 - 1 2 - 8 2 1 0 5 8 - 1

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 2 1 2 4 4 - 8

Chitosan in Biomedical Applications provides a thorough insight into the complete chitosan chemistry, collection, chemical modifications, characterization and applications of… Read more

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Chitosan in Biomedical Applications provides a thorough insight into the complete chitosan chemistry, collection, chemical modifications, characterization and applications of chitosan in biomedical applications and healthcare fields. Chitosan, a biopolymer of natural origin, has been explored for its variety of applications in biomedical research, medical diagnostic aids and material science. It is the second most abundant natural biopolymer after cellulose, and considered as an excellent excipient because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of chitosan in biomedical applications. The book explores key topics, such as molecular weight, degree of deacetylation, and molecular geometry, along with an emphasis on recent advances in the field written by academic, industry, and clinical researchers. Chitosan in Biomedical Applications will be of interest to those in biomedical fields including the biomaterials and tissue engineering community investigating and developing biomaterials for biomedical applications, particularly graduate students, young faculty and others exploring chitosan-based materials.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1. Chitosan: a versatile biopolymer
1. Introduction
2. Chitosan
3. Biomedical application of chitosan
4. Conclusion
Chapter 2. Antimicrobial uses of chitosan
1. Introduction
2. Chemistry of chitin and chitosan
3. Chitosan and its derivatives as antibacterial agents
4. Chitosan and its derivatives as antifungal agents
5. Chitosan and its derivatives as antiviral agents
6. Effects of degree of deacetylation and molecular weight on antimicrobial action of chitosan
7. Conclusions
Chapter 3. Microscale and nanoscale chitosan-based particles for biomedical use
1. Introduction
2. Microscale biomedical approaches
3. Nanoscale biomedical approaches
Chapter 4. Biomedical applications of electrospun chitosan nanofibers
1. Introduction
2. General properties of chitosan
3. Extraction of chitosan
4. Electrospun nanofibers: fundamental process, parameters, and challenges
5. Biomedical applications of electrospun chitosan nanofibers
6. Conclusion and future perspectives
Chapter 5. Chitosan nanocomposites for biomedical applications
1. Introduction
2. Chitosan
3. Chitosan nanocomposites in drug delivery
4. Chitosan nanocomposites in gene delivery
5. Chitosan nanocomposites in tissue engineering
6. Chitosan nanocomposites in wound healing
7. Antimicrobial chitosan nanocomposites
8. Chitosan nanocomposites in bioimaging
9. Conclusion
Chapter 6. Uses of chitosan in drug delivery
1. Introduction
2. Chitosan extraction
3. Properties of chitosan and its implications in drug delivery application
4. Drug delivery applications
5. Conclusion
Chapter 7. Tumor targeting strategies by chitosan-based nanocarriers
1. Introduction
2. Chitosan
3. Factors affecting the efficacy of chitosan-based nanocarriers
4. Anticancer drug delivery using chitosan-based nanocarriers
5. Chitosan-based nanocarriers for passive targeting to tumors
6. Chitosan-based nanocarriers for active targeting of tumors
7. Chitosan-based stimuli-responsive nanocarrier systems for targeting
8. Conclusion
Chapter 8. Environmental stimuli-sensitive chitosan nanocarriers in therapeutics
1. Introduction
2. Temperature-sensitive drug delivery system
3. pH-sensitive drug delivery system
4. Ultrasound-sensitive drug delivery system
5. Redox-sensitive drug delivery system
6. Photo-sensitive drug delivery system
7. Magnetic field-sensitive drug delivery system
8. Conclusion
Chapter 9. Protein and peptide delivery by chitosan systems
1. Introduction
2. Salient features of chitosan for delivery of protein and peptides
3. N-Trimethyl chitosan
4. Chitosan and its derivative-based carrier systems for protein and peptide delivery
5. Conclusions and perspective
Conflict of interest
Chapter 10. Gene and growth factor delivery by chitosan systems
1. Introduction
2. Gene delivery
3. Growth factor delivery
4. Chitosan systems for growth factor delivery
Chapter 11. Mucosal vaccination through chitosan-based delivery systems
1. Mucosal vaccination
2. Chitosan as a smart polymer
3. Conclusions
Chapter 12. Enzyme immobilization using chitosan systems
1. Introduction
2. Immobilization methods
3. Chitosan configurations
4. Horseradish peroxidase
5. Glucose oxidase
6. β-Galactosidase
7. Conclusions
Abbreviations and Acronyms
Chapter 13. Applications of chitosan in orthopedics and dentistry
1. Introduction
2. Structure and properties of chitosan
3. Human skeleton
4. Orthopedics challenges and solutions
5. Grafting
6. Tissue engineering
7. Three-dimensional bio-printing
8. Orthopedic and dental applications of chitosan
9. Conclusion
Chapter 14. Chitosan-based scaffolds in tissue engineering and regenerative medicine
1. Introduction
2. Chitosan
3. Applications of chitosan-based scaffolds for bone regeneration
4. Applications of chitosan-based scaffolds for cartilage regeneration
5. Applications of chitosan-based scaffolds for dermal tissue regeneration
6. Applications of chitosan-based scaffolds for nerve tissue regeneration
7. Applications of chitosan-based scaffolds for vascular tissue regeneration
8. Applications of chitosan-based scaffolds for corneal tissue regeneration
9. Applications of chitosan-based scaffolds in regeneration of hepatic tissue
10. Applications of chitosan-based scaffolds for cardiac tissue regeneration
11. Conclusion
Chapter 15. Coating of chitosan onto bone implants
1. Introduction
2. Chitosan coating
3. Factors affecting chitosan properties for use as bioactive coating
4. Methods of chitosan coating on titanium for bone implants
5. Other coatings based on chitosan
6. Bioactivity of chitosan-coated titanium implants
7. Future scopes and challenges
8. Conclusions
Chapter 16. Bioimaging applications of chitosan-based systems
1. Introduction
2. Chitosan properties
3. Application of chitosan in bioimaging techniques
4. Conclusions
Index

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 10 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 70 publications in various high impact peer-reviewed journals, more than 100 book chapters and 16 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record in Google Scholar (h-index: 32). He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Palamau Institute of Pharmacy, Daltonganj, Jharkhand, India

Sarwar Beg

Sarwar Beg, PhD is currently serving as AMS-DBT Newton International Fellow at University of Central Lancashire, UK, and working in the area of glioblastoma research using targeted nanomedicines. He is also serving as the Assistant Professor at Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi. He has over a decade of teaching and research experience in the field of pharmaceutics and biopharmaceutics, especially in the development of novel and nanostructured drug delivery systems using Quality-by-Design paradigms with core expertise in computational pharmaceutics, experimental designs and multivariate statistical techniques. He has authored over 200 publications, 60 book chapters, 15 books, 03 Indian patent applications and H-Index of 40 with over 5400 citations to his credit.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi, India

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India