Chemistry of 2-Oxoaldehydes and 2-Oxoacids
- 1st Edition - September 28, 2021
- Imprint: Elsevier
- Authors: Atul Kumar, Javeed Rasool, Qazi Naveed Ahmed
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 2 8 5 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 2 8 6 - 5
Chemistry of 2-Oxoaldehydes and 2-Oxoacids offers complete coverage on 2-oxoaldehydes and 2-oxoacid, which to date have not been covered in a comprehensive manner. Novel reactions… Read more
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Request a sales quoteChemistry of 2-Oxoaldehydes and 2-Oxoacids offers complete coverage on 2-oxoaldehydes and 2-oxoacid, which to date have not been covered in a comprehensive manner. Novel reactions related to 2-oxoaldehydes and 2-oxoacids on keto and aldehydic groups (both participating separately or in combination), decarboxylative reactions, spectral analysis and diverse applications are explored. The book is divided into two parts, with the first outlining methods for the preparation and physical properties of 2-Oxoaldehydes, along with the structure, spectral characteristics and reactivity of 2-Oxoaldehydes. The second part covers the preparation and physical properties of 2-Oxoacids and the synthesis of many related reactions.
This book is essential reading for researchers working on these types of reactions in organic chemistry, medicinal chemistry, natural product chemistry and pharmaceutical chemistry.
- Covers various synthetic procedures for the synthesis of 2-Oxoaldehydes and 2-Oxoacids
- Provides information about different types of reactions, such as C-H activation reactions, coupling reactions, decarboxylative reactions, and nucleophilic reactions for the synthesis of different biologically active compounds
- Includes the use of 2-Oxoaldeehyde and 2-Oxoacid as the starting point for the synthesis of different synthons that can be used for various medicinally important compounds
Researchers working in organic synthesis. Researchers working in catalysis, synthesis of biological active compounds, natural product synthesis, carbohydrate chemistry
Part A1 Synthesis and physical properties of 2-Oxoaldehydes and 2-Oxoacids.1.1 Introduction of 2-Oxoaldehydes.1.2 Methods of Preparation of 2-Oxoaldehydes.1.3 Physical properties and Thermal Stability of 2-Oxoaldehydes.1.4 Reactivity of 2-Oxoaldehydes.1.5 Introduction of 2-Oxoacids.1.6 Methods for preparation of 2-Oxoacids.1.7 Physical properties of 2-Oxoacids.1.8 Importance of 2-Oxoacids in BiologyReferences.
2 Structure and spectral characteristics of 2-Oxoaldehydes and 2-Oxoacids2.1 Reactivity comparison of 2-Oxoaldehydes with aldehydes2.2 Nature of the chemical bonds in 2-Oxoaldehydes2.3 Spectral characteristics2.3.1 Infrared spectra2.3.2 1H NMR spectra2.3.3 13C NMR spectra2.4 Reactivity comparison of 2-Oxoacids with acids.2.5 Nature of the chemical bonds in 2-Oxoacids2.6 Spectral characteristics2.6.1 Infrared spectra2.6.2 1H NMR spectra2.6.3 13C NMR spectraReferences.
3 Applications of 2-Oxoaldehydes3.1 Reactions from Aldehyde group3.1.1 Synthesis of Aroylaziridines3.1.2 Synthesis of oxirane3.1.3 Synthesis of Ketoamide3.1.4 Synthesis of 2-Oxoacetamidine3.1.5 Synthesis of 1,2-disubstituted benzimidazoles3.1.6 Synthesis of imidazoles3.1.7 Synthesis of Lactones3.1.8 Synthesis of 3,1-Benzoxathiin-4-one3.1.9 Synthesis of Dihydrothiopyrans3.1.10 Synthesis of Benzoyltetrazole3.1.11 Synthesis of Tetrahydrofurans3.1.12 Synthesis of Tetrahydropyridines3.1.13 Others3.2 Reactions from Keto group3.2.1 Synthesis of α-Hydroxy Aldehydes.3.2.2 Synthesis of Cyclic Ketals3.3 Reactions from both Keto and Aldehyde group3.3.1 Synthesis of 6-Aminophenanthridines3.3.2 Synthesis of Triazinopurinedione3.3.3 Synthesis of Imidazotriazines3.3.4 Synthesis of Pyrrolidines3.3.5 Synthesis of pyrroles3.3.6 Synthesis of 4-Hydroxy-5-phenylpyrazoles3.3.7 Synthesis of Pyrazole and Pyridazinone3.3.8 Synthesis of Hydantoins and Thiohydantoins3.3.9 Synthesis of Imidazoles3.3.10 Synthesis of Imidazol-2-ones and Imidazolin-4-one3.3.11 Synthesis of Imidazothiazoles and Imidazopyridines3.3.12 Synthesis of Imidazopyridazines and Imidazopyrazinones3.3.13 Synthesis of 1,2,3-Triazoles and Tetrazoles3.3.14 Synthesis of furan3.3. 15 Synthesis of Tetrahydro- and Dihydrofurans3.3.16 Synthesis of formoins3.3.17 Synthesis of Benzofurans3.3.18 Synthesis of Furofuran3.3.19 Synthesis of Bis-dioxolane3.3.20 Synthesis of Isoxazoles3.3.21 Synthesis of Oxazolones3.3.22 Synthesis of Oxazole3.3.23 Synthesis of Thiazolidines and Thiazolines3.3.24 Synthesis of Dioxophospholanes3.3.25 Synthesis of Tetrahydroquinolines and Quinolines3.3.26 Synthesis of Pyridazines3.3.27 OthersReferences.
Part B4. Applications of 2-Oxoacids.4.1 Decarboxylative Reactions.4.1.1 Acylated Product synthesis4.1.2 Ketone Synthesis4.1.3 Thioester Synthesis4.1.4 α,β -Unsaturated Carbonyls Synthesis4.1.5 Ynones synthesis4.1.6 Amide synthesis4.1.7 Ester Synthesis4.1.8 N-aroylsulfoximine Synthesis4.2 Keto amide and Keto ester Synthesis4.3 Heterocyclic Compounds Synthesis4.4 Multicomponent Reactions4.5 Ynediones Synthesis.4.6 Aldehyde and Acid Synthesis.4.7 Reactions at Keto group4.8 Diketone Synthesis.4.9 Miscellaneous reactionsReferences.
5 Summary
- Edition: 1
- Published: September 28, 2021
- Imprint: Elsevier
- No. of pages: 292
- Language: English
- Paperback ISBN: 9780128242858
- eBook ISBN: 9780128242865
AK
Atul Kumar
Atul Kumar completed his BSc from G.G.M. Science College, Jammu, India, and his MSc from the University of Jammu, Jammu, India. After being awarded the CSIR-Junior Research Fellowship, he joined Dr. Qazi Naveed’s research group at the CSIR-Indian Institute of Integrative Medicine, Jammu. His doctoral work is mainly based on “α-Carbonyl Assisted Unconventional Applications of 2-Oxoaldehydes & 2-Oxoesters and Medicinal Chemistry around Ciprofloxacin.” He completed his PhD from the Academy of Scientific and Innovative Research (AcSIR), Delhi in 2019. He also worked as a postdoctoral fellow at Department of Chemistry and Chemical Sciences, Central University of Jammu from 2019 to 2021. At present, he is working as an Institutional Postdoctoral Fellow in the Department of Chemistry, Indian Institute of Technology, Bombay, India. His research interest are the total synthesis of natural products, biologically active scaffolds, and development of novel synthetic transformations.
Affiliations and expertise
Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, IndiaJR
Javeed Rasool
Mr. Javeed Rasool received his BSc (Honours) from Poona College, Pune, India, and his MSc with a specialization in organic chemistry from the University of Pune, Pune, India. He was involved in undergraduate teaching courses for two years and he had previously he developed interest in organic chemistry research while completing his BEd. He joined the CSIR-Indian Institute of Integrative Medicine as a project assistant in 2016. After being awarded the CSIR-Junior Research Fellowship he worked in Dr. Qazi Naveed’s research group at CSIR- Indian Institute of Integrative Medicine, Jammu, and the doctoral programme in chemical sciences. His current research interests are focused on natural product and medicinal chemistry and development of novel methods in glycochemistry.
Affiliations and expertise
Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, IndiaQA
Qazi Naveed Ahmed
Qazi Naveed Ahmed obtained his PhD. from Kashmir University under the combined supervision of Dr. H. M. Sampath Kumar and Prof. M. A. Qureshi at the CSIR-Indian Institute of Integrative Medicine. His doctoral research was focused on the “Synthesis of Some Biologically Active Compounds and Development of New Synthetic Methodologies.” He completed his post-doctoral fellowship at the University of Paris Sud-XI, Parisa, France, under the CNRS program in the Glycochemistry Division under Prof. David Bonnaffe. In 2012, he obtained a scientific position in the CSIR-Indian Institute of Integrative Medicine Jammu as a Principal Scientist. His current research interests are medicinal chemistry for the development of novel anti-bacterial/anticancer agents, and development of new synthetic methodologies.
Affiliations and Expertise
Affiliations and expertise
Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine (CSIR), Jammu, Jammu and Kashmir, IndiaRead Chemistry of 2-Oxoaldehydes and 2-Oxoacids on ScienceDirect