Characterization of Biomaterials
- 1st Edition - December 19, 2012
- Editors: M Jaffe, W. Hammond, P Tolias, T Arinzeh
- Language: English
- Hardback ISBN:9 7 8 - 1 - 8 4 5 6 9 - 8 1 0 - 2
- Paperback ISBN:9 7 8 - 0 - 0 8 - 1 0 1 6 2 4 - 4
- eBook ISBN:9 7 8 - 0 - 8 5 7 0 9 - 3 6 8 - 4
Biomaterials and medical devices must be rigorously tested in the laboratory before they can be implanted. Testing requires the right analytical techniques. Characterization of… Read more
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Request a sales quote- Reviews the latest methods for analyzing the structure, properties and behaviour of biomaterials
- Discusses scattering techniques for structural analysis, quantitative assays for measuring cell adhesion, and motility and differentiation
- Examines the evaluation of cell infiltration and tissue formation using bioreactors
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Chapter 1: Microscopy techniques for analyzing the phase nature and morphology of biomaterials
Abstract:
1 Introduction: basic imaging concepts
1.2 Image perception and interpretation
1.3 Light microscopy
1.4 Laser scanning confocal microscopy (LSCM)
1.5 Scanning electron microscopy (SEM)
1.6 Atomic force microscopy (AFM)
Chapter 2: Scattering techniques for structural analysis of biomaterials
Abstract:
2.1 Introduction
2.2 Light scattering
2.3 Wide-angle X-ray diffraction
2.4 Measuring orientation using X-ray diffraction
2.5 Small-angle scattering techniques
2.6 Small-angle X-ray scattering (SAXS)
2.7 Small-angle neutron scattering (SANS)
2.8 Acknowledgment
Chapter 3: Quantitative assays for measuring cell adhesion and motility in biomaterials
Abstract:
3.1 Introduction
3.2 Cell attachment assays
3.3 Cell adhesion strength
3.4 Collective motility of cell populations
3.5 Individual cell motility
3.6 Conclusion and future trends
Chapter 4: Assays for determining cell differentiation in biomaterials
Abstract:
4.1 Introduction
4.2 Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) assays
4.3 Protein and chemical assays
4.4 Imaging assays
4.5 Future trends
Chapter 5: Bioreactors for evaluating cell infiltration and tissue formation in biomaterials
Abstract:
5.1 Introduction
5.2 Bioreactor designs
5.3 Evaluation of cell infiltration and cell seeding
5.4 Evaluation of tissue formation
5.5 Importance of computational fluid mechanics in modeling, imaging, and simulation of the bioreactors
5.6 Failure of bioreactors
5.7 Future trends
5.8 Conclusion
5.9 Sources of further information and advice
Chapter 6: Studying molecular-scale protein–surface interactions in biomaterials
Abstract:
6.1 Introduction: surface-induced thrombosis on artificial surfaces
6.2 Process and changes during protein adsorption
6.3 Factors affecting protein adsorption
6.4 Models of protein adsorption and adsorption isotherms
6.5 Protein adsorption kinetics
6.6 The Vroman effect
6.7 Structure and functions of fibrinogen
6.8 Intermolecular forces and interactions
6.9 Adsorption profile and interfacial kinetics
6.10 Competitive adsorption
6.11 Atomic force microscopy (AFM)
6.12 Interfacial properties of fibrinogen studied by AFM
6.13 Future trends
6.14 Conclusion
Chapter 7: Assessing the mutagenic effects of biomaterials: analyzing the cellular genome and abnormalities
Abstract:
7.1 Introduction
7.2 DNA structure
7.3 Genetic mutations
7.4 Cytogenetic mutations
7.5 Types of mutations that can occur at the chromosomal level
7.6 Methods of detection of cytogenetic mutations
7.7 Analyzing genomic organization and variations in genomic copy number
7.8 Copy number variations (CNVs)
7.9 Epigenetic effects on the genome
7.10 Effects of biomaterials on mutagenesis
7.11 Conclusion
Chapter 8: Using microarrays to measure cellular changes induced by biomaterials
Abstract:
8.1 Introduction
8.2 What do we measure?
8.3 Normalization
8.4 Analysis
8.5 Conclusion
Chapter 9: Standards and methods for assessing the safety and biocompatibility of biomaterials
Abstract:
9.1 Introduction
9.2 Regulatory definition of medical devices
9.3 International Standards Organization (ISO) regulation and guidance
9.4 United States Food and Drug Administration (FDA) regulation and guidance
9.5 Regulation and guidance in Japan and other countries
9.6 Biological tests
9.7 Phasing (timing) of non-clinical testing of medical devices
Index
- No. of pages: 334
- Language: English
- Edition: 1
- Published: December 19, 2012
- Imprint: Woodhead Publishing
- Hardback ISBN: 9781845698102
- Paperback ISBN: 9780081016244
- eBook ISBN: 9780857093684
MJ
M Jaffe
WH
W. Hammond
PT
P Tolias
TA