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Central Nervous System Malignancies, An Issue of Hematology/Oncology Clinics of North America
- 1st Edition, Volume 36-1 - November 24, 2021
- Editor: David A. Reardon
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 1 0 7 2 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 1 0 7 3 - 9
In this issue of Hematology/Oncology Clinics, guest editor David A. Reardon︎ brings his considerable expertise to the topic of Central Nervous System Malignancies. Top experts in… Read more
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Request a sales quoteIn this issue of Hematology/Oncology Clinics, guest editor David A. Reardon︎ brings his considerable expertise to the topic of Central Nervous System Malignancies. Top experts in the field cover key topics such as CNS Metastases, Leptomeningeal Disease, Neurofibromatoses, Imaging Advances for CNS Tumors, and more.
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Contains 16 relevant, practice-oriented topics including CNS Tumor Classification: An Update on the Integration of Tumor Genetics; Etiology and Epidemiology of CNS Tumors; The Evolving Role of Neurosurgical Intervention for CNS Tumor ; Update on Radiation Therapy for CNS Tumors; and more.
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Provides in-depth clinical reviews on CNS Malignancies, offering actionable insights for clinical practice.
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Central Nervous System Tumor Classification: An Update on the Integration of Tumor Genetics
- Key points
- Introduction and general principles
- Diffuse gliomas
- Circumscribed astrocytomas
- Malignant gliomas of childhood and young adults and their biomarkers
- Diffuse low-grade gliomas and glioneuronal tumors of childhood
- Clinics care points
- The Epidemiology of Central Nervous System Tumors
- Key points
- Introduction
- Incidence in the United States—variation by age at diagnosis, sex, race/ethnicity, and histologic type of tumor
- Inherited genetic syndromes and polymorphisms
- Nongenetic risk factors
- Lifestyle factors
- Future directions
- Clinics care points
- Imaging Advances for Central Nervous System Tumors
- Key points
- Introduction
- Current standard imaging of central nervous system tumors
- Advanced imaging techniques
- PET-18F-fluoroethyltyrosine and other novel tracers
- Artificial intelligence-radiomic applications in central nervous system tumor imaging
- Summary
- Clinics care points
- The Evolving Role of Neurosurgical Intervention for Central Nervous System Tumors
- Key points
- Introduction
- Relieving symptoms and providing tissue
- Impacting outcomes: the quest for maximal tumor resection and how to get there
- Enabling therapeutic and scientific advancements
- Driving therapeutic and scientific advancements
- Embracing different tools
- Toward a lab-in-a-patient revolution
- Final considerations
- Clinics care points
- Update on Radiation Therapy for Central Nervous System Tumors
- Key points
- Introduction
- Gliomas
- Brain metastases
- Meningioma
- Disclosure
- Isocitrate Dehydrogenase Mutant Grade II and III Glial Neoplasms
- Key points
- Molecular pathogenesis of isocitrate dehydrogenase mutant glioma
- Clinical presentation of isocitrate dehydrogenase mutant glioma
- Current treatment of lower grade glioma
- Development of isocitrate dehydrogenase mutant inhibitors
- Other therapeutic approaches for isocitrate dehydrogenase mutant glioma
- Evaluation of treatment response and tumor growth in isocitrate dehydrogenase mutant glioma
- Clinics care points
- Isocitrate Dehydrogenase Wild-type Glial Tumors, Including Glioblastoma
- Key points
- Introduction
- Discussion
- Summary
- Clinics care points
- Disclosure
- Biology and Treatment of Meningiomas: A Reappraisal
- Key points
- Introduction
- Meningioma origin and location
- Diagnostic considerations
- Considerations for deciding on observation versus treatment
- Role of surgery
- Indications for radiotherapy
- Systemic therapies for treatment-refractory recurrent/progressive meningioma
- Challenges in meningioma clinical trial design
- Summary
- Clinics care points
- Primary Central Nervous System Lymphomas
- Key points
- Introduction
- Epidemiology
- Pathology
- Clinical manifestations and diagnosis
- Upfront treatment
- Elderly patients with primary central nervous system lymphoma
- Refractory and relapsed primary central nervous system lymphoma
- Monitoring and follow-up
- Funding
- Clinics care point
- Central Nervous System Metastases
- Key points
- Introduction
- Epidemiology
- Pathophysiology
- Prevention and early identification
- Presentation
- Diagnostic evaluation
- Management
- Prognosis and clinical outcomes
- Ongoing research
- Summary and future directions
- Clinics care points
- Leptomeningeal Disease
- Key points
- Introduction
- Epidemiology
- Biology and pathogenesis
- Clinical presentation
- Diagnostic testing including cerebrospinal fluid cytology, liquid biopsy, imaging
- Treatments
- Prognosis
- Summary
- Central Nervous System Complications Among Oncology Patients
- Key points
- Central nervous system complications of radiation therapy
- Central nervous system complications of chemotherapy
- Monoclonal antibodies and antibody drug conjugates
- Small molecule inhibitors
- Immunotherapy
- Summary
- Clinics care points
- Acknowledgment
- Is There a Role for Immunotherapy in Central Nervous System Cancers?
- Key points
- Immunosuppression in glioblastomas
- Immune checkpoint therapy
- Vaccine therapy in glioblastoma
- Adoptive cellular therapy: introduction
- Clinics care points
- Neurofibromatoses
- Key points
- Neurofibromatosis type 1
- Neurofibromatosis type 2
- Schwannomatosis
- Clinics care points
- Disclosures
- Neurocognition and Health-Related Quality of Life Among Patients with Brain Tumors
- Key points
- Introduction
- Neurocognition
- Patient characteristics
- Tumor-related factors
- Treatment-related factors
- Other contributors
- Prevention and intervention
- Health-related quality of life
- Discussion and future directions
- Summary
- Clinics care points
- Disparities and Inequities Among Patients with Central Nervous System Tumor
- Key points
- Introduction
- Challenges to access to health care
- Clinical trial enrollment
- Diversity of the neuro-oncology workforce
- Summary
- Clinics care points
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 36-1
- Published: November 24, 2021
- Imprint: Elsevier
- Hardback ISBN: 9780323810722
- eBook ISBN: 9780323810739
DR
David A. Reardon
Affiliations and expertise
Clinical Director
Center for Neuro-Oncology
Dana-Farber Cancer Institute
Boston, MA