Cellular Mechanism for Calcium Transfer and Homeostasis
- 1st Edition - January 1, 1971
- Imprint: Academic Press
- Editor: George Jr. Nichols
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 5 1 8 0 5 0 - 4
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 1 4 2 9 9 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 4 6 1 5 - 9
Cellular Mechanisms for Calcium Transfer and Homeostasis presents the proceedings of the Workshop Conference on Cell Mechanisms for Calcium Transfer and Homeostasis, held at… Read more
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Request a sales quoteCellular Mechanisms for Calcium Transfer and Homeostasis presents the proceedings of the Workshop Conference on Cell Mechanisms for Calcium Transfer and Homeostasis, held at Portsmouth, New Hampshire on September 13, 1970. This book examines the ubiquity of the involvement of calcium in the function and structure of biological systems. Comprised of seven parts encompassing 26 chapters, this book starts with the ramifications of calcium and its various roles in the body’s economy. This text then discusses how calcium is absorbed by an active cation-oriented transport process. Other chapters explore the fundamental roles of calcium as a component of bone mineral, as well as in the control of cell replication and growth. This text also examines the structural organization of the nerve cell membrane. The final chapter presents data on calcium transport across cellular and subcellular membranes. This book is a valuable resource for biologists, cellular biologists, researchers, and students.
List of Contributors
Preface
Credits
Acknowledgments
Franklin Chambers McLean and the State of Calcium in Body Fluids
I. The State of Calcium in Body Fluids
The Structure, Properties, and Formation of Calcium Phosphates in Hard Tissue
Introduction
Hydroxyapatite Structure
Carbonate Apatites
Bone Apatite
Amorphous Calcium Phosphate in Bone Mineral
Tissue Mineralization
Conclusions
References
Discussion
Differentiation Processes in Calcified Tissues
Introduction
Development as a General Process
Development in Bone and Dental Tissues
Conclusion
References
Discussion
The Binding of Calcium with Nucleic Acids and Phospholipids
General Procedures
Nucleic Acids
Phospholipids
Conclusions and Summary
References
Discussion
Chemical Structure of Bone Sialoprotein and a Preliminary Study of Its Calcium-Binding Properties
Isolation of Bone Sialoprotein
Composition of BSP
Physical Properties of BSP
Binding of Radioelements to BSP
Calcium Binding and Inhibition of Calcium Phosphate Precipitation
Conclusion
References
Discussion
II. Role of Calcium in Membrane Structure and Integrity
The Biionic Action Potential and Indispensability of Divalent Cations in the External Medium for Nerve Excitation
Introduction
Intracellular Perfusion of the Squid Giant Axon
Effects of Calcium Ions Inside the Axon
The Biionic Action Potential
Ionic Mechanism of Nerve Excitation
Change in the Hydrophobicity of the Membrane Macromolecules during Nerve Excitation
Conclusions
References
Discussion
The Calcium Homeostatic System as a Physiological Regulator of Cell Proliferation in Mammalian Tissues
Introduction
Basic Phenomena
Mechanism
Physiological Significance
Summary
References
Discussion
III. Calcium Transfer across Cell and Subcellular Membranes
A Calcium Pump in Red Cell Membranes
Text
References
Discussion
Calcium Transport in Kidney Cells and Its Regulation
Calcium Pools
Calcium Fluxes
A Model for Cellular Calcium Metabolism
References
Discussion
Recent Observations on the Mechanism of Ca2+ Transport by Fragmented Sarcoplasmic Reticulum Membranes
Introduction
Role of Phospholipids in ATPase Activity and Calcium Transport
Protein Composition of Sarcoplasmic Reticulum Membranes
Isolation of a Phosphopeptide from Microsomal Membranes Labeled with AT32P or Acetyl-32P
References
Discussion
IV. Cell Mechanisms in Mineralized Tissues
The Concept of a Bone Membrane: Some Implications
Text
References
Discussion
Bone Cells, Calcification, and Calcium Homeostasis
Text
References
Discussion
The Role of Mitochondria in Intracellular Calcium Regulation
Experimental Protocol
Method
Results
Summary
References
Discussion
Bone Formation and Resorption by Osteocytes
Introduction
Methods
Results
Discussion
Conclusions
References
Discussion
V. Calcium Transfer Across Epithelial Tissues
Intestinal Calcium Absorption, Vitamin D, Adaptation, and the Calcium-Binding Protein
A Dual Effect of Vitamin D?
Adaptation
Synthesis of CaBP in Organ Culture
Concluding Remarks
Summary
References
Discussion
Vagaries in the Use of Isolated Intestinal Mucosal Cell Preparations with Particular Emphasis on Calcium Uptake
Introduction
Materials and Methods
Results
Summary and Conclusions
References
Discussion
Active Transport of Calcium across Placenta and Mammary Gland Measured in Vivo
Introduction
Placental Calcium Transport
Mammary Calcium Transport
References
Discussion
Calcium Transfer across the Avian Shell Gland
Introduction
Anatomical Considerations
Autoradiographic Localization of Calcium
Calcium Transport Studies
Mitochondria and Metal Ion Translocation
References
Discussion
Active Transcellular Transport of Calcium by Embryonic Chick Chorioallantoic Membrane
Electron Probe Investigations
Oxygen Consumption and Active Calcium Transport
Sulfhydryl Groups and Calcium Transport
Concluding Remarks
References
Discussion
VI. Sites and Modes of Action of Humoral Factors
Chemistry of Parathyroid Hormone
Isolation
Sequence Analysis
Synthesis: Properties of the Synthetic Peptide
Conclusion
References
Discussion
Physiological Importance of Thyrocalcitonin
Text
References
Discussion
Metabolism and Mechanism of Action of 25-Hydroxycholecalciferol
Physiological Actions of Vitamin D
Metabolism of Vitamin D
Metabolism of 25-HCC
Mechanism of Action of Vitamin D
References
Discussion
Induction of Bone Resorption in Tissue Culture: Interaction of Humoral Agents and Ions
Induction Model
Role of RNA Synthesis
Role of Cyclic Adenosine 3', 5'-Monophosphate (cAMP)
Synergism between PTH and 25-HCC
Effect of Thyrocalcitonin
Effect of Calcium on Induction
Conclusion
References
Discussion
Abstracts of Submitted Papers
I. Calcification
Time Study of in Vivo Incorporation of 32P-Orthophosphate into Phospholipids of Chicken Epiphyseal Tissues
Metabolic Activity at the Cement Line of Bone
Calcification of the Cartilage Formed on Avian Bones
Evidences of a Direct Effect of Vitamin D3 or 25-Hydroxycholecalciferol upon Human Adult Bone Mineralization
Role of Protein-Polysaccharide Aggregates as a Biological Inhibitor of Mineral Growth
Calcification of Cartilage by Means of Mineralized Spherules
Decalcified Bone Implants under Hormonal Influence
Mechanism of Calcification
Biological Role of Heterologous Antibodies against Cartilage Protein Polysaccharide Complex Light Fraction (PP-L)
Isolation of Membrane-Bounded Extracellular Particles Associated with Calcification in Cartilage Matrix
Electron Microscope Measurements of Alkaline Earth Transport
Calcium Transport and Calcification Studies by Microperfusion
II. Calcitonin: Calcium Ion Activity and Pharmacological Action: Tooth Formation
47Ca Turnover of a Readily Exchangeable Calcium Pool in Pregnant and Lactating Cows
Metabolic Clearance Rate of Radioiodinated Human Calcitonin in Man
Extraosseous Actions of Calcitonin
Crystal-Matrix Relationship in Amelogenesis
Different Isozymes of Acid Phosphatase in Bone and Developing Teeth
Provisional Calcification of Cartilage in Tissue Culture
Bone Cell Response to Serum Calcium-Altering Drugs
Calcium Ion Activity in Plasma: Effects of Metabolic and Respiratory Acid-Base Changes
A Calcium Concentration Dependent Hypocalcemic Effect of Calcitonin in the Perfused Dog Limb
Natriuric Effect of Calcitonin in Man
Remissions in Paget's Disease Produced by Human Synthetic Calcitonin (Calcitonin M)
Relationship between Alkaline Phosphatase, Inorganic Pyrophosphatase, and L-Ascorbic Acid in Calcifying Hamster Molars
III. Diphosphonates; Bone Resorption; Osteoporosis
Mechanical Effects on Cell Mechanisms in Bone
Canalicular and Interstitial Changes in Osteocytic Osteolysis
Effect of Calcium Deficiency on Healing of Experimental Fractures in the Avian Tarsus as Determined by the Fracture Repair Ratio
Effect of Phosphonates on Bone Tissue: Studies in Man and Animals
Sites and Modes of an Estrogen-Gestagen Combination on Calcium and Phosphate Metabolism in Senile Osteoporosis
Resorption of Bone Collagen by Multinucleated Giant Cells
Effect of Disodium Ethane-1-hydroxy-1,1-diphosphonate on Bone Formation in Animals
Effectiveness of Diphosphonates in Preventing Osteoporosis of Disuse in the Rat
Osteoporosis and Parathyroid Glands: The Effect of Prolonged Calcium Deficiency on Thyroparathyroidectomized Adult Rats
Role of a Lipoprotein in the Intracellular Hydroxyapatite Formation in Bacterionema Matruchotii
Hormonal Effects on Calcium Transport in Liver
IV. Intestinal Absorption of Calcium and Bone Metabolism
Osteocyte as a Bone Pump
25-Hydroxycholecalciferol (25-HCC): Effects in Deficiency Rickets and Vitamin D-Resistant Rickets
Induction of Calcium-Binding Protein (CaBP) Biosynthesis by Vitamin D3 and 25-Hydroxycholecalciferol (25-HCC)
Effect of Cortisol on Calcium-Binding Protein in Rat Duodenum
A Study of Nephron Permeability to Calcium by Microinjection Technique
A Study of Calcium-Binding Proteins in Human Animal Small Bowel Mucosa
A Method for Studying the Configuration, Dimensions, and Distribution of Remodeling Centers on the Endosteal, Cortical, and Trabecular Surfaces
Transport of Iodoantipyrine-125I (I-Ap) In Cortical Bone
Ca2+ Sensitive ATPase In Duodenal Mucosa: Localization in Basal Membranes
Refractive Index of Newly Forming Bone Tissue
Bovine Serum Albumin (BSA) Calcium-Binding Studies with a Calcium-Selective Liquid Membrane Electrode
Passage of Calcium and Strontium across the Intestine in Man
Concept of Electropositive Crystal Bond Based on Ossification and Other Phenomena
Subject Index
- Edition: 1
- Published: January 1, 1971
- No. of pages (eBook): 556
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780125180504
- Paperback ISBN: 9780124142992
- eBook ISBN: 9780323146159
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