Cellular Energy Metabolism and its Regulation
- 1st Edition - September 28, 1977
- Imprint: Academic Press
- Author: Bozzano G Luisa
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 3 9 6 0 0 2 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 3 8 7 6 - 5
Cellular Energy Metabolism and Its Regulation examines the metabolic and molecular aspects of living organisms. Beginning with a discussion of evolutionary design and its close… Read more
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Request a sales quoteCellular Energy Metabolism and Its Regulation examines the metabolic and molecular aspects of living organisms. Beginning with a discussion of evolutionary design and its close analogy with human design, it emphasizes the notion that evolution is a process of functional design, and that the characteristics of an organism, whether morphological or molecular, were selected because of functional advantage to the organism's ancestors. Thus, the study of an enzyme, a reaction, or a sequence can be biologically relevant only if its position in the hierarchy of function is kept in mind. This book deals with some aspects of metabolism from that point of view. The key concepts discussed include the conservation of solvent capacity and energy; functional stoichiometric coupling and metabolic prices; adenylate control and the adenylate energy charge; aspects of enzyme behavior that appear to be related to metabolic control; interactions between metabolic sequences; and the adenylate energy charge in intact cells. This book was designed for graduate students in biochemistry, physiology, microbiology, and related fields. However, it may also be useful to senior undergraduate students and more advanced workers who have a direct or peripheral interest in energy metabolism. It assumes a general familiarity with the material covered in a standard biochemistry textbook as well as some knowledge of such related areas as genetics.
Preface
1 Introduction: Evolutionary Design
2 Conservation of Solvent Capacity and of Energy
Conservation of Solvent Capacity
Conservation of Energy
Summary
3 Functional Stoichiometric Coupling and Metabolic Prices
Functional Coupling
Types of Metabolic Stoichiometries
The ATP Equivalent
Unidirectionality
Metabolic Costs of Growth
Summary
4 Adenylate Control and the Adenylate Energy Charge
Kinetic Control of Metabolism
The Adenylate Energy Charge
Roles of Adenylates in Metabolism
Summary
5 Enzymes as Control Elements
Single or Noninteracting Sites
Interacting Sites and Cooperativity
Graphical Representation of Enzyme Responses
Basis of Cooperativity
Binding Energies and Enzyme Action
Summary
6 Interactions between Regulatory Parameters
Amphibolic Sequences
Anabolic Sequences
Interactions between Sequences
Summary
7 The Adenylate Energy Charge in Intact Cells
Stability of Concentrations and Concentration Ratios
Energy Charge, Adenylate Pool, and Functional Capacities
Summary
8 General Summary and Discussion
Appendix A Some Elementary Aspects of Thermodynamics
The First Law of Thermodynamics
The Second Law of Thermodynamics
Appendix B "High-Energy Bonds," Thermodynamics, and Open Systems
Appendix C The Briggs-Haldane Treatment
Bibliography
Index
- Edition: 1
- Published: September 28, 1977
- No. of pages (eBook): 293
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780123960023
- eBook ISBN: 9780323138765
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