Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B

1st Edition, Volume 366 - January 24, 2022

Editors: Lorenzo Galluzzi, Niccolo Bartalucci

Hardback ISBN:

9 7 8 - 0 - 3 2 3 - 8 9 9 4 1 - 3

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 8 9 9 4 2 - 0

Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B, Volume 366 in the International Review of Cell and Molecular Biology series, highlights new advances in… Read more

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Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B, Volume 366 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Sections cover Genetic and Sex predisposition to MPN, Transcriptional configurations of Myeloproliferative Neoplasms, Inhibitors and therapeutic targets of MPN, Mutational landscape of blast-phase myeloproliferative neoplasm (MPN-BP) and antecedent MPN, and Lessons from Mouse model of MPN, Lab tests for MPN.

Cover image
Title page
Table of Contents
Copyright
Contributors
Philadelphia-negative myeloproliferative neoplasms: From origins to new perspectives
Acknowledgments
Conflict of Interest
References
Chapter One: The roles of sex and genetics in the MPN
Abstract
Key Points
1: Introduction
2: Sex as a factor in MPN epidemiology
3: Biologic basis of sex differences in somatic mutation burden
4: Genetic predisposition to CH and the MPN
5: Heritable risk factors for CH and MPN
6: Inflammation as a risk for CH and MPN
7: Mutation burden and clinical risk
8: Conclusion
Funding
Conflicts of interest
References
Chapter Two: Transcriptional configurations of myeloproliferative neoplasms
Abstract
1: Introduction
2: Studies on the bulk transcriptome of MPN patients
3: From bulk to single cell transcriptomic sequencing of MPN patients
4: Analysis of splicing abnormalities with RNA-seq
5: Analysis of fusion genes in MPN and post-MPN AML patients
6: Concluding remarks and future directions
References
Chapter Three: Targets in MPNs and potential therapeutics
Abstract
1: Introduction
2: JAK2 mutations
3: TPOR/MPL inhibition strategies
4: CALR mutations
5: Other targeted therapies
6: Conclusion
Acknowledgments
References
Chapter Four: Mutational landscape of blast phase myeloproliferative neoplasms (MPN-BP) and antecedent MPN
Abstract
1: Introduction
2: Importance of activated JAK/STAT signaling and driver mutations
3: Driver mutations and beyond in MPN and leukemic transformation
4: Conclusions
Acknowledgments
Disclosures
References
Chapter Five: Lessons from mouse models of MPN
Abstract
1: “Of mice and Men”
2: MPN driver mutations via the JAK2/STAT signaling pathway
3: Modeling MPN in mice—An up-to-date description
4: Lessons from MPN mouse modeling: What it means for patients
5: Conclusions and remarks
Acknowledgments
References
Chapter Six: Lab tests for MPN
Abstract
1: Philadelphia chromosome (Ph) positive myeloproliferative neoplasms (Ph + MPNs)
2: Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs)
3: Source of sample and DNA template for genetic testing in MPNs
4: Conclusions
References

Lorenzo Galluzzi

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Affiliations and expertise

Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA

Niccolo Bartalucci

Niccolo Bartalucci practices in Florence, Italy. Dr. Bartalucci is highly rated in 6 conditions, according to our data. His top areas of expertise are Essential Thrombocythemia, Myelofibrosis, Polycythemia Vera, and Splenomegaly. His clinical research consists of co-authoring 34 peer reviewed articles in the past 15 years.

Affiliations and expertise

Department of Experimental and Clinical Medicine, University of Florence, Italy