Cell Sources for iPSCs
- 1st Edition - May 9, 2021
- Imprint: Academic Press
- Editor: Alexander Birbrair
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 1 3 5 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 3 2 7 - 7
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Somati… Read more
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Request a sales quoteThe series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years.
Cell Sources for iPSCs, Volume 7 teaches readers about current advances in the field. It shares up-to-date comprehensive overviews of current advances in the field. This book describes the derivation of iPSCs from different sources in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. The authors focus on the modern state-of-art methodologies and the leading-edge concepts in the field of stem cell biology. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. Thus, this book is an attempt to describe the most recent developments in iPSCs biology, which is one of the rising hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on how we derive iPSCs from distinct sources. Ten chapters written by experts in the field summarize the present knowledge about different cell sources for iPSCs.
This volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years.
Cell Sources for iPSCs, Volume 7 teaches readers about current advances in the field. It shares up-to-date comprehensive overviews of current advances in the field. This book describes the derivation of iPSCs from different sources in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. The authors focus on the modern state-of-art methodologies and the leading-edge concepts in the field of stem cell biology. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. Thus, this book is an attempt to describe the most recent developments in iPSCs biology, which is one of the rising hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on how we derive iPSCs from distinct sources. Ten chapters written by experts in the field summarize the present knowledge about different cell sources for iPSCs.
This volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.
- Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics
- Covers the following: myoblast-derived iPSCs, lymphoblastoid-derived iPSCs, amniotic fluid stem cell–derived iPSCs, spermatogonial stem cell–derived iPSCs, iPSCs derived from postmortem tissue, and more
- Contributed by world-renowned experts in the field
Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields
- Cover image
- Title page
- Table of Contents
- Advances in Stem Cell Biology
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Chapter 1. Induced pluripotent stem cells derived from amniotic fluid stem cells
- Introduction
- Induced pluripotent stem cells derived from amniotic fluid stem cells
- Summary
- Chapter 2. Induced pluripotent stem cells from spermatogonial stem cells: potential applications
- Introduction
- Spermatogonial stem cell as source of pluripotent stem cells (Germline cell-derived pluripotent stem cells)
- Molecular characteristics of germline cell-derived pluripotent stem cells
- Differentiative potential of germline cell-derived pluripotent stem cells
- Multipotency of spermatogonial stem cell
- Future trends and perspectives
- Chapter 3. Induced pluripotent stem cell derivation from myoblasts
- Introduction
- Induced pluripotent stem cells
- Chapter 4. Lymphoblastoid-derived human-induced pluripotent stem cells: a new tool to model human diseases
- hiPSC technology
- Limitations to the use of human-induced pluripotent stem cells
- Lymphoblastoids
- Establishing human-induced pluripotent stem cells from lymphoblastoid cell lines
- Differentiation of lymphoblastoid cell line–derived human-induced pluripotent stem cells into functional cardiac, neuronal, and muscle cells
- Conclusion
- Chapter 5. Oral tissues as sources for induced pluripotent stem cell derivation and their applications for neural, craniofacial, and dental tissue regeneration
- Introduction
- Oral tissues as a cell source to generate induced pluripotent stem cells
- Limitation of dental tissues–derived mesenchymal stem cells and the advantage of induced pluripotent stem cells as a cell source for craniofacial regeneration
- Application of induced pluripotent stem cells in dental and craniofacial regeneration
- Application of induced pluripotent stem cells in studying inherited/genetic dental diseases
- Current challenges and future prospective of induced pluripotent stem cells
- Conclusion
- Chapter 6. Induced pluripotent stem cell derived from ovarian tissue
- Introduction
- Stem cells
- Adult stem cells
- Embryonic stem cells
- Induced pluripotent stem cells
- Homotypic differentiation
- Ovarian anatomy and function
- Disruption of ovarian function and treatment options
- The reproductive system
- Ovarian development
- Oogenesis and stem cells
- Anatomy of the ovarian follicle
- Functions of the ovary and the hypothalamic-pituitary-ovarian axis
- Induced pluripotent stem cell-mediated regeneration of ovarian tissue
- Granulosa cells as a source for generating induced pluripotent stem cells
- Induced pluripotent stem cell reprogramming methods
- Virus-free technique
- Sendai viral generation of induced pluripotent stem cells
- Retroviral generation of induced pluripotent stem cells
- Verification of induced pluripotent stem cell pluripotency
- Induced pluripotent stem cell differentiation
- Steroidogenic tissue
- Homotypic differentiation of ovarian cells
- Clinical translation
- Future directions
- An autologous model for cell-based stem cell therapies
- Chapter 7. Muse cells as a robust source of induced pluripotent stem cells
- Introduction
- The characteristics of Muse cells
- Fibroblasts are a heterogenous cell population
- Pluripotent-like Muse cells are more prone to become induce pluripotent stem cells than general fibroblasts
- Can the generation of induce pluripotent stem cells from pluripotent-like Muse cells be considered reprogramming?
- Muse cells are realistic source of induce pluripotent stem cells
- Different reporting systems may cause uncertainty in reprogramming efficiency
- Chapter 8. Prostate cancer reprogramming and dedifferentiation into induced pluripotent stem cells
- Introduction
- Luminal-like versus stem-like prostate cancer cell types
- Adenocarcinoma versus nonadenocarcinoma and small cell carcinoma
- Stem cell transcription factor expression in LuCaP lines
- Low B2M expression in stem cells and stem-like LuCaP
- In vitro maintenance of LuCaP lines and reprogramming of LuCaP adenocarcinoma
- Stromal induction of stem cells in organ development
- Organ-specific stromal genes and identification of prostate-specific stromal cell factors
- Absent expression of organ-specific stromal genes in cancer-associated stromal cells
- Use of co-culture with stem cells to study stromal cell function
- Stromal proenkephalin induction of LuCaP 145.1
- The effect of proenkephalin on adenocarcinoma LuCaP 70CR
- Summary
- Future research
- Comparison between inactivation of stem cell transcription factor by proenkephalin and other means
- Prevention of reprogramming by proenkephalin
- Incubation of LuCaP 145.1 in proenkephalin-containing media
- Incubation of LuCaP 145.1 with media from cultured NPstrom
- Proenkephalin influence on lung small cell carcinoma
- Mechanism of proenkephalin on stem cell transcription factor transcription suppression
- Other questions
- Chapter 9. Melanoma-derived induced pluripotent stem cells: a model for understanding melanoma cell of origin and drug resistance
- Introduction
- Melanoma—a malignancy of melanocytes
- Embryonic origin and distribution of melanocytes
- Subtypes of melanoma
- Diversity of melanoma driver mutations: indicators of distinct cell of origin?
- Melanoma cell of origin: human studies
- Zebrafish as a model for cell of origin of melanoma
- Melanoma cell of origin: lessons from mouse models
- Cancer cell–derived induced pluripotent stem cell: a strategy to dissect cancer cell of origin?
- Melanoma-derived induced pluripotent stem cells: relevance to cell of origin and melanoma drug resistance
- Conclusions/perspectives
- Chapter 10. Induced pluripotent stem cell derived from postmortem tissue in neurodegenerative disease research
- Introduction
- Induced pluripotent stem cells
- Validation of induced pluripotent stem cell
- Disease modeling using induced pluripotent stem cell
- Neurodegenerative disease
- Alzheimer disease
- Frontotemporal dementia
- Amyotrophic lateral sclerosis
- Vascular dementia
- Lewy body dementia
- Parkinson disease
- Conclusions
- Index
- Edition: 1
- Published: May 9, 2021
- No. of pages (Paperback): 280
- No. of pages (eBook): 280
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128221358
- eBook ISBN: 9780128223277
AB
Alexander Birbrair
Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
Affiliations and expertise
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Department of Radiology, Columbia University Medical Center, Medical Center, USARead Cell Sources for iPSCs on ScienceDirect