Cell Polarity in Development and Disease
- 1st Edition, Volume 154 - April 25, 2023
- Editor: Ulrich Tepass
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 1 5 8 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 1 6 5 - 7
Cell Polarity in Development and Disease, Volume 154 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapte… Read more
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Request a sales quoteCell Polarity in Development and Disease, Volume 154 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cell polarity in the protist-to-animal transition, Polarized actin networks in development: Case studies from Drosophila, Protein clustering and cell polarization, Polarity in the Drosophila female germline, Context Matters: Mechanisms governing epithelial polarization in C. elegans, Epithelial polarity in the fly: Principles and diversity, Polarizing epithelial expulsion and expulsion driven by mispolarization, The Role of Apical-Basal Polarization in the Mammalian First Cell Fate Decision, and much more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Methods in Cell Biology series
- Updated release includes the latest information on Cell Polarity in Development and Disease
Scientists and researchers
- Cover image
- Title page
- Table of Contents
- Current Topics in DEVELOPMENTAL BIOLOGY
- Series page
- Current Topics in DEVELOPMENTAL BIOLOGY
- Copyright
- Contributors
- Preface
- Chapter One: Cell polarity in the protist-to-animal transition
- Abstract
- 1 Introduction
- 2 The apico-basal polarity of animal epithelial cells and its molecular control
- 3 The first polarized elements from the LECA: flagella, microtubules, basal bodies
- 4 Elements of the basal lamina and of focal adhesions in the amoebozoan/opisthokont (amorphean) ancestor
- 5 Obazoan and filozoan ancestors: origin of Cdc42 and Par6: coordinating polarity and actin polymerization
- 6 Filozoan ancestor: MAGUK proteins, cadherins, filopodial contacts, and the ancestry of cell-cell adhesions
- 7 Choanozoan ancestors and the origin of apical microvilli
- 8 Metazoan ancestors: origin of epithelial architecture and the explosion of polarity proteins
- 9 Conclusion
- Acknowledgments
- References
- Chapter Two: Context matters: Lessons in epithelial polarity from the Caenorhabditis elegans intestine and other tissues
- Abstract
- 1 Introduction to epithelia and C. elegans
- 2 Defining the C. elegans polarity network
- 3 The intestine
- 4 Variations on a theme: polarity lessons from other C. elegans epithelia
- 5 Conclusions and outlook
- Acknowledgments
- References
- Chapter Three: Polarity and axis formation in the Drosophila female germ line
- Abstract
- 1 Overview of oogenesis
- 2 Asymmetric stem cell division
- 3 Oocyte determination
- 4 Oocyte polarisation
- 5 The posterior positioning of the oocyte
- 6 The polarising signal
- 7 Polarising the anterior-posterior axis
- 8 Polarising the dorsal ventral-axis
- 9 Concluding remarks
- Acknowledgements
- References
- Chapter Four: Contractile and expansive actin networks in Drosophila: Developmental cell biology controlled by network polarization and higher-order interactions
- Abstract
- 1 Introduction
- 2 Supracellular contractile networks
- 3 Interactions of Arp2/3 networks and actomyosin networks
- 4 Concluding remarks
- Acknowledgments
- References
- Chapter Five: Cell polarity and extrusion: How to polarize extrusion and extrude misspolarized cells
- Abstract
- 1 Introduction
- 2 Cell extrusion, a polarized remodeling process
- 3 Polarity perturbations as a driving force for cell extrusion and death induction
- 4 Conclusions and perspectives
- References
- Chapter Six: The role of polarization and early heterogeneities in the mammalian first cell fate decision
- Abstract
- 1 Introduction
- 2 Establishment of apical-basal polarity
- 3 Linking polarity and cell fate
- 4 The first cell fate decision beyond apical-basal polarity
- 5 Summary and discussion
- Acknowledgments
- References
- Chapter Seven: Polarity in immune cells
- Abstract
- 1 Introduction
- 2 Cell polarity and immune cell migration
- 3 Polarity at the immune synapse
- 4 Asymmetric cell division in lymphocytes
- 5 Conclusions and perspectives
- References
- Chapter Eight: Fat and Dachsous cadherins in mammalian development
- Abstract
- 1 Introduction
- 2 Drosophila Fat and Dachsous
- 3 Mammalian Fat and Dachsous
- 4 Conclusions and remaining questions
- References
- Chapter Nine: Polarity in breast development and cancer
- Abstract
- 1 Introduction
- 2 Models to study cell polarity in breast epithelia
- 3 Mammary gland development
- 4 Roles for apical-basal polarity proteins in breast cancer initiation and progression
- 5 Breast cancer treatment and resistance
- 6 Perspectives
- References
- Chapter Ten: Polarity in respiratory development, homeostasis and disease
- Abstract
- 1 Introduction
- 2 Polarity and respiratory development
- 3 Polarity and lung homeostasis
- 4 Respiratory epithelial polarity and disease
- 5 Conclusions and outlook
- Acknowledgments
- References
- Chapter Eleven: Polarity in skin development and cancer
- Abstract
- 1 Introduction to epidermal cell types and architecture
- 2 Development of the epidermis
- 3 Polarity in the epidermis
- 4 Core polarity machinery
- 5 Mechanical polarity across the epidermis
- 6 Planar cell polarity in the epidermis
- 7 Polarity and skin cancer
- 8 Concluding remarks
- References
- No. of pages: 352
- Language: English
- Edition: 1
- Volume: 154
- Published: April 25, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780128201589
- eBook ISBN: 9780128201657
UT
Ulrich Tepass
Ulrich Tepass is at University of Toronto, Ontario, Canada
Affiliations and expertise
University of Toronto, Ontario, CanadaRead Cell Polarity in Development and Disease on ScienceDirect