Cell Biology
- 4th Edition - March 8, 2023
- Latest edition
- Authors: Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz, Graham Johnson
- Language: English
Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrat… Read more
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Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods—from single cell RNA sequencing to second generation super resolution fluorescence microscopy—on advancing our understanding.
- Clear, readable explanations provide a concise story about how cells function at the molecular level
- An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology
- Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases
- Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation
- Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices
Students and Faculty in Medical/PA programs, Undergrad and Grad programs in Biology/Biomedicine/Biomedical Engineering/Cell Biology/Biochemistry/Biophysics/Molecular Biology/Physiology/Bioscience
SECTION I Introduction to Cell Biology
1. Cells as the Basis of Life on Earth
2. Evolution of Life on Earth
SECTION II Chemical and Physical Background
3. Molecules: Structures and Dynamics
4. Biophysical Principles
5. Macromolecular Assembly
6. Research Strategies
SECTION III Chromatin, Chromosomes, and the Cell Nucleus
7. Chromosome Organization
8. DNA Packaging in Chromatin and Chromosomes
9. Nuclear Structure and Dynamics
SECTION IV Central Dogma: From Gene to Protein
10. Gene Expression
11. Eukaryotic RNA Processing
12. Protein Synthesis and Folding
SECTION V Membrane Structure and Function
13. Membrane Structure and Dynamics
14. Membrane Pumps
15. Membrane Carriers
16. Membrane Channels
17. Membrane Physiology
SECTION VI Cellular Organelles and Membrane Trafficking
18. Posttranslational Targeting of Proteins
19. Mitochondria, Chloroplasts, Peroxisomes
20. Endoplasmic Reticulum
21. Mechanisms of Vesicular Transport
22. Secretory Membrane System and Golgi Apparatus
23. Endocytosis and the Endosomal Membrane System
24. Processing and Degradation of Cellular Components
SECTION VII Signaling Mechanisms
25. Plasma Membrane Receptors
26. Protein Hardware for Signaling
27. Second Messengers
28. Integration of Signals
SECTION VIII Cellular Adhesion and the Extracellular Matrix
29. Cells of the Extracellular Matrix and Immune Systems of Animals
30. Extracellular Matrix Molecules
31. Cellular Adhesion
32. Intercellular Junctions
33. Connective Tissues
SECTION IX Cytoskeleton and Cellular Motility
34. Actin and Actin-Binding Proteins
35. Microtubules and Centrosomes
36. Intermediate Filaments
37. Motor Proteins
38. Intracellular Motility
39. Cellular Motility
40. Muscles
SECTION X Cell Cycle
41. Introduction to the Cell Cycle
42. G1 Phase and Regulation of Cell Proliferation,
43. S Phase and DNA Replication
44. G2 Phase: Responses to DNA Damage and Control of Entry Into Mitosis
45. Mitosis
46. Cytokinesis
47. Meiosis
48. Cell Death
1. Cells as the Basis of Life on Earth
2. Evolution of Life on Earth
SECTION II Chemical and Physical Background
3. Molecules: Structures and Dynamics
4. Biophysical Principles
5. Macromolecular Assembly
6. Research Strategies
SECTION III Chromatin, Chromosomes, and the Cell Nucleus
7. Chromosome Organization
8. DNA Packaging in Chromatin and Chromosomes
9. Nuclear Structure and Dynamics
SECTION IV Central Dogma: From Gene to Protein
10. Gene Expression
11. Eukaryotic RNA Processing
12. Protein Synthesis and Folding
SECTION V Membrane Structure and Function
13. Membrane Structure and Dynamics
14. Membrane Pumps
15. Membrane Carriers
16. Membrane Channels
17. Membrane Physiology
SECTION VI Cellular Organelles and Membrane Trafficking
18. Posttranslational Targeting of Proteins
19. Mitochondria, Chloroplasts, Peroxisomes
20. Endoplasmic Reticulum
21. Mechanisms of Vesicular Transport
22. Secretory Membrane System and Golgi Apparatus
23. Endocytosis and the Endosomal Membrane System
24. Processing and Degradation of Cellular Components
SECTION VII Signaling Mechanisms
25. Plasma Membrane Receptors
26. Protein Hardware for Signaling
27. Second Messengers
28. Integration of Signals
SECTION VIII Cellular Adhesion and the Extracellular Matrix
29. Cells of the Extracellular Matrix and Immune Systems of Animals
30. Extracellular Matrix Molecules
31. Cellular Adhesion
32. Intercellular Junctions
33. Connective Tissues
SECTION IX Cytoskeleton and Cellular Motility
34. Actin and Actin-Binding Proteins
35. Microtubules and Centrosomes
36. Intermediate Filaments
37. Motor Proteins
38. Intracellular Motility
39. Cellular Motility
40. Muscles
SECTION X Cell Cycle
41. Introduction to the Cell Cycle
42. G1 Phase and Regulation of Cell Proliferation,
43. S Phase and DNA Replication
44. G2 Phase: Responses to DNA Damage and Control of Entry Into Mitosis
45. Mitosis
46. Cytokinesis
47. Meiosis
48. Cell Death
- Edition: 4
- Latest edition
- Published: March 8, 2023
- Language: English
TP
Thomas D. Pollard
Thomas Dean Pollard is a prominent educator, cell biologist and biophysicist whose research focuses on understanding cell motility through the study of actin filaments and myosin motors. He is Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Cell Biology and Molecular Biophysics & Biochemistry at Yale University. He was Dean of Yale's Graduate School of Arts and Sciences from 2010 to 2014, and President of the Salk Institute for Biological Studies from 1996 to 2001. Pollard is very active in promoting scientific education and research primarily through two major societies, both of which he is a past President: the American Society for Cell Biology and the Biophysical Society
Affiliations and expertise
Sterling Professor, Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USAWE
William C. Earnshaw
William Charles Earnshaw is Professor of Chromosome Dynamics at the University of Edinburgh where he has been a Wellcome Trust Principal Research Fellow since 1996. Earnshaw is an elected Fellow of the Royal Society since 2013 for his studies of mitotic chromosome structure and segregation. Before Edinburgh, he was Professor of Cell Biology and Anatomy at Johns Hopkins School of Medicine.
Affiliations and expertise
Professor and Wellcome Trust Principal Research Fellow, Wellcome Trust Centre for Cell Biology, ICB, University of Edinburgh, Scotland, UKJL
Jennifer Lippincott-Schwartz
Jennifer Lippincott-Swartz is Group Leader at the Howard Hughes Medical Institute Janelia Research Campus. Her lab uses live cell imaging approaches to analyze the spatio-temporal behaviour and dynamic interactions of molecules in cells with a special focus on neurobiology. Before Janelia, Lippincott-Swartz was a primary investigator and chief of the Section on Organelle Biology in the Cell Biology and Metabolism Branch. Her work there included a collaboration with physicists Eric Betzig and Harald Hess (now group leaders at Janelia), who proposed a new function for the photoactivatable protein. The scientists used the protein to generate photoactivatable fluorophores, or dyes, which enabled them to illuminate different sets of molecules sequentially, creating a microscope image far more detailed than previously possible. The method, called super-resolution microscopy, garnered Betzig the 2014 Nobel Prize in Chemistry.
Affiliations and expertise
Group Leader, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, USAGJ
Graham Johnson
Graham Johnson is a computational biologist and Certified Medical Illustrator (CMI) with approx. 20 years of professional experience. He is Director of the Animated Cell at the Allen Institute. Before the Allen Institute, Johnson’s lab in the California Institute for Quantitative Biosciences at the University of California, San Francisco worked to generate, simulate and visualize molecular models of cells. His lab’s Mesoscope project and his team at Allen Institute continue this mission by uniting biologists, programmers and artists to interoperate the computational tools of science and art.
Affiliations and expertise
Director, Animated Cell, Allen Institute for Cell Biology, Seattle, Washington;, QB3 Faculty Fellow, University of California, San Francisco, San Francisco, California, USA