Catecholamines and Schizophrenia

I. Stereotyped Behavior and Amphetamine PsychosisPrologue Pharmacology and Physiology of Stereotyped Behavior Discussion Amphetamine Phychosis: Behavioral and Biochemical Aspects A Two Factor Theory of Schizophrenia Stereoselective Features of Catecholamine Disposition and Their Behavioral Implications Effects of Amphetamines on the Metabolism of Catecholamines in the Rat Brain A Mass Fragmentographic Study of Amphetamine and Metabolites in rat Brain DiscussionII. Antipsychotic Drugs and Catecholamine Synapses Antipsychotic Drugs and Catecholamine Synapses Dose Equivalence of the Antipsychotic Drugs Brief Communications: Catecholamines and Antipsychotic Drugs in Periodic Catatonia A Pilot Study of Pimozide in Schizophrenia Dopaminergic Blocking Effects of Antipsychotic Drugs Mass Fragmentometric Determination of Homovanillic Acid in Lumbar Cerebrospinal Fluid of Schizophrenic Patients during Treatment with Antipsychotic Drugs New Developments in the Study of the Mechanism of Action of Neuroleptics and Amphetamine Biochemical Characterization of the Dopamine Receptor in the Mammalian Caudate Nucleus Antischizophrenic Drugs: Affinity for Muscarinic Cholinergic Receptor Sites in the Brain Predicts Extrapyramidal Effects Antipsychotic Drugs and Catecholamine Synapses. Summary of the Session Discussion Dopamine and the Pharmacology of Schizophrenia: The State of the EvidenceIII. Biogenic Amines and Behavior Self-stimulation Reward Pathways: Norepinephrine vs Dopamine Relationship of Biogenic Amines to Behavior Role of Dopamine and Norepinephrine in the Chemistry of Reward Consideration of some Problems Encountered in Relating Specific Neurotransmitters to Specific Behaviors or Disease Central Dopamine Neurons and Sensory Processing Central Catecholamine Neurons, Behavior and Neuroleptic Drugs: An Analysis to Understand the Involvement of Catecholamines in Schizophrenia Brain Dopamine and Behavior. A Critical Analysis of the Relationship between Dopamine Antagonism and Therapeutic Efficacy of Neuroleptic Drugs The Role of Adaptive Regulation in the Pathophysiology of Psychiatric Disease Discussion Behavioral Effects of Central Catecholamines. Concluding RemarksIV. Chemical Neuropathology of Schizophrenia Post-mortem Measurement of Enzymes in Human Brain: Evidence of a Central Noradrenergic Deficit in Schizophrenia Post-mortem Fluorescence Histochemistry of Monoamine Neuron Systems in the Human Brain: A New Approach in the Search for a Neuropathology of Schizophrenia Studies on Dopamines-Hydroxylase in Mental Disorders Behavioral Effects of a New Dopamine-β-Hydroxylase Inhibitor (Fusaric Acid) in Man Discussion Monoamine Oxidase in Schizophrenia and Other Behavioral Disorders Some Remarks Concerning the Possible Role of Brain Monoamines (Dopamine, Noradrenaline, Serotonin) in Mental Disorders Analysis of Glutamate Decarboxylase in Post-mortem Brain Tissue in Huntington's Chorea A New Hypothesis on the Origin of Schizophrenia N5.1-Methylenetetrahydrofolate Reductase Deficiency and Schizophrenia: A Working Hypothesis Discussion Problems of Interpretation in the Chemical Pathology of SchizophreniaV. Recent Advances in Historical Technology Introduction: Quantitative Histochemistry Recent Developments in Monoamine Histochemistry Dopamine Histofluorescence in Post-mortem Specimens of Human and Rat Striatum Localization of the Noradrenergic Nervous System in Human Brain Enzymatic-Isotopic Micromethods for the Measurement of Biogenic Amines in Brain Tissue and Body Fluids Genetic Control of Biogenic Amines and the Possibilities Offered by New Microanalytical Techniques for the Investigation of Human Cerebrospinal Fluid Multiple Detection: A New Tool for Neurochemistry and Biological Psychiatry DiscussionVI. Enzymology and Regulation of Catecholamine Enzymes Dopamine-Beta-Hydroxylase Immunological Localization of Dopamine-Beta-Hydroxylase on the Chromaffin Granule MembraneBrief Communication: The Subunit Structure and Carbohydrate Content of Bovine Adrenal Dopamine-β-Hydroxylase Discussion Introductory Remarks on Monoamine Oxidase On the Physico-Chemical Characterization of Monoamine Oxidase (MAO) as a Basis for the Study of its Role in Physiological and Pathological Processes Discussion Regulation of Catecholamine-Synthesizing Enzymes The Regulation of the Noradrenergic Neuron Genetic Differences in Mechanisms Involving NeuroregulatorsBrief Communication: Possible Role of Catecholamines (CH) in the Regulation of Adrenal Tyrosine Hydroxylase (TH) DiscussionEpilogueContributorsSubject Index