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Calcium Regulation of Cellular Function

  • 1st Edition, Volume 30 - July 21, 1998
  • Editors: Anthony R. Means, Paul Greengard, Angus C. Nairn, Shirish Shenolikar
  • Language: English
  • Hardback ISBN:
    9 7 8 - 0 - 1 2 - 0 3 6 1 3 0 - 4
  • eBook ISBN:
    9 7 8 - 0 - 0 8 - 0 5 5 2 7 3 - 6

Volume 30 examines the prominent role of calcium as an intracellular second messenger. Leading investigators review a wide variety of studies on how calcium enters and moves… Read more

Calcium Regulation of Cellular Function

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Volume 30 examines the prominent role of calcium as an intracellular second messenger. Leading investigators review a wide variety of studies on how calcium enters and moves through cells, how it interacts with its many binding proteins, and how calcium and its intracellular receptor, calmodulin, control vital cellular processes. Coverage includes a detailed analysis of the mechanisms by which calcium bound to calmodulin regulates contractile proteins in smooth muscle cells. Close attention is given to the roles of calcium and calmodulin-dependent protein kinases and phosphatases in synaptic signal transduction, protein synthesis, gene expression, programmed cell death, activation of T-lymphocytes, and control of cell division cycles. Other chapters discuss studies using genetically manipulable nonmammalian organisms to further proble the functions of calcium and calmodulin.