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Elsevier

Building Blocks of Neuroimmunometabolism

From Molecular Pathways to Therapeutic Strategies

  • 1st Edition - October 25, 2026
  • Latest edition
  • Editors: Sachchida Nand Rai, Shradha Bisht, Swati Prakash
  • Language: English

Building Blocks of Neuroimmunometabolism: From Molecular Pathways to Therapeutic Strategies offers an authoritative exploration of the intricate relationship between the immune… Read more

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Description

Building Blocks of Neuroimmunometabolism: From Molecular Pathways to Therapeutic Strategies offers an authoritative exploration of the intricate relationship between the immune system and neurodegenerative diseases. This essential resource addresses the critical gap in understanding how immune responses and metabolic processes jointly influence the onset and progression of conditions such as Alzheimer’s, Parkinson’s, and multiple sclerosis. The book provides an examination of key molecular pathways and cellular interactions, emphasizing the role of immunometabolism in disease mechanisms. Beginning with an introduction to the concept of immunometabolism, it explores the connections between the immune and nervous systems, setting the stage for understanding neurodegenerative diseases.

In addition, the book discusses pivotal topics such as the role of microglia and macrophages in neuroinflammation, the metabolic regulation of T cells, and the impact of oxidative stress and mitochondrial dysfunction. The gut-brain axis is examined for its influence on brain health, alongside innovative therapeutic strategies targeting immunometabolic pathways and lifestyle interventions.

Key features

  • Integrates immunology and metabolism, enhancing understanding of their combined role in neurodegenerative disease progression
  • Offers insights into targeting immunometabolic pathways for innovative therapeutic strategies in neurodegenerative disorders
  • Explores the gut-brain axis, highlighting its impact on brain health and neurodegeneration
  • Provides cutting-edge research on immune cell interactions and metabolic changes in neuroinflammation
  • Highlights emerging technologies for precision medicine applications in neurodegenerative disease treatment

Readership

Immunologists and Neuroscientists, Pharmacologists and Biochemists, Cell Biologists and Molecular Biologists, Neurologists, Neuropsychologists, Drug Developers, Clinical Research Scientists

Table of contents

1. Introduction to Neuroimmunometabolism: Connecting Immune and Nervous Systems

2. Molecular Pathways Linking Immunity and Neurodegeneration

3. Role of Macrophages in Immunometabolism and Neurodegeneration

4. Role of Microglia in Neurodegenerative Disorders

5. Metabolic Regulation of T Cells in Neuroinflammation

6. Oxidative Stress and Mitochondrial Dysfunction in Immune-Mediated Neurodegeneration

7. Role of Cytokines and Chemokines in Neurodegenerative Disease Progression

8. The Gut-Brain Axis: Immunometabolic Crosstalk in Neurodegenerative Diseases

9. Inflammatory Pathways in Alzheimer’s Disease: The Immunometabolic Perspective

10. Parkinson’s Disease and Immune-Metabolic Dysregulation

11. Multiple Sclerosis: Immune and Metabolic Interactions in Neuroinflammation

12. Autoimmune Diseases and Their Role in Neurodegeneration

13. Immunometabolism in Aging and Neurodegenerative Disorders

14. Therapeutic Potential of Targeting Immuno-metabolic Pathways and Lifestyle Interventions on Immunometabolism and Neurodegeneration

15. Emerging Technologies for Studying Immunometabolism in Neurodegenerative Disorders

16. Future Directions: Bridging Immunometabolism and Precision Medicine in Neurology

Product details

  • Edition: 1
  • Latest edition
  • Published: October 25, 2026
  • Language: English

About the editors

SR

Sachchida Nand Rai

Dr. Sachchida Nand Rai is an Associate Professor at Saveetha Institute of Basic Medical Sciences (SIBMS), Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University . He obtained his MSc in Biochemistr from Purvanchal University, India, and his PhD in Biochemistry from Banaras Hindu University, India. Dr. Rai researches the anti-oxidative and anti-neuroinflammatory properties of phytochemicals for the treatment of neurodegenerative diseases. He is a lifetime member of the Indian Academy of Neuroscience.

Affiliations and expertise
Assistant Professor

SB

Shradha Bisht

Dr. Shradha Bisht is a Professor at the Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand. She earned her Ph.D. in Pharmacy from the Rajasthan University of Health Sciences, Jaipur, and her Master of Pharmacy (Pharmacology) from The Maharaja Sayajirao University of Baroda, Vadodara. Dr. Bisht has established herself as an accomplished academician and researcher with expertise in pharmacology, phytopharmacology, neuropharmacology, endocrinology, and metabolic disorders. She has authored more than 60 research articles and several book chapters published by leading international publishers. Her research primarily focuses on the preclinical evaluation of the therapeutic potential of drugs for neurological, endocrine, and metabolic disorders, with particular emphasis on natural products and translational pharmacology. Her academic excellence has been recognized through several prestigious honors, including the Professor of the Year Award (2025), the Young Women Scientist Achievement Award (2024), and the Innovative Teacher Award (2020). In addition to supervising Ph.D. and M.Pharm. scholars, Dr. Bisht actively contributes to scientific research, academic leadership, and professional development through her participation in national and international conferences, faculty development programmes, and collaborative research initiatives.

Affiliations and expertise
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.

SP

Swati Prakash

Dr. Swati Prakash, an Assistant Professor of Pharmacology, is a dedicated researcher with a Ph.D. in Pharmacology from the Indian Institute of Technology (BHU), Varanasi, and a Master's degree from Guru Ghasidas University, Bilaspur. Her research spans neurodegenerative disorders, immunometabolism, metabolic complications, and advanced drug delivery systems. Dr. Prakash has contributed significantly to the understanding of chronic inflammation and cancer, exploring key pathways and targeted therapies. Her published work on the regulation of adipose tissue inflammation and hepatic Adiponectin/AMPK levels demonstrates her expertise in addressing metabolic syndrome and fatty liver disease. Through her innovative research, Dr. Prakash is advancing the field of pharmacology, focusing on therapeutic approaches that improve health outcomes. Her academic credentials and impactful publications underscore her commitment to scientific excellence and her role as a leading researcher in pharmacological sciences.
Affiliations and expertise
Amity Institute of Pharmacy, Amity University, Lucknow, Uttar Pradesh, India