Bronchiectasis, An Issue of Clinics in Chest Medicine

1st Edition, Volume 43-1 - March 3, 2022
Editor: James D. Chalmers
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 6 9 0 - 0
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 6 9 1 - 7

In this issue, guest editors bring their considerable expertise to this important… Read more

Bronchiectasis, An Issue of Clinics in Chest Medicine

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In this issue, guest editors bring their considerable expertise to this important topic.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Bronchiectasis from 2012 to 2022
Key points
Introduction
Epidemiology-a growing problem and growing awareness
Registries and large datasets
Guidelines
Pathophysiology
Clinical trials
The 2022 series-moving forwards
Clinics care points
Diagnosis and Evaluation of Bronchiectasis
Key points
Introduction
Making the diagnosis of bronchiectasis
Etiologic evaluation
Clinics care point
Prognostic evaluation
Microbiologic evaluation
Follow-up and evaluation of treatment outcomes
Clinics care points
Summary
Microbiology and the Microbiome in Bronchiectasis
Key points
Introduction
The microbiology of the bronchiectasis airway
Immunologic correlates of microbial infection
The role of allergy and fungal exposure in bronchiectasis
The era of the microbiome—current insights and perspectives
The bacteriome in bronchiectasis
The mycobiome in bronchiectasis
The virome in bronchiectasis
Integrating microbial ecosystems to advance bronchiectasis research
Summary
Clinics Care Points
The Pathogenesis of Bronchiectasis
Key points
Introduction
Initiating factors
Perpetuating factors
Summary
Radiology of Bronchiectasis
Key points
Introduction
Defining bronchiectasis on computed tomography
Classic descriptive appearances
Clinical computed tomographic evaluation
Computer analysis of bronchiectasis
Quantitative computed tomographic analysis
Challenges in bronchiectasis quantification
Quantitative MRI analysis
Summary
Clinics care points
Bronchiectasis and Chronic Obstructive Pulmonary Disease Overlap Syndrome
Key points
Introduction
Why might chronic obstructive pulmonary disease and bronchiectasis coexist in the same patient?
Reasons for coexistence of bronchiectasis and chronic obstructive pulmonary disease
Radiological issues in diagnosing bronchiectasis in chronic obstructive pulmonary disease
Are bronchiectasis and chronic obstructive pulmonary disease commonly diagnosed?
What has been learned from the literature to date?
Impact on mortality
Is the overlap between chronic obstructive pulmonary disease and bronchiectasis important?
Implications for investigations
Implications for management
What treatments are commonly applied in one condition but not the other?
Summary
Clinics care points
Bronchiectasis in Childhood
Key points
Introduction
Incidence and prevalence
Burden
Etiology of bronchiectasis
Role of nutrition
Pathology and pathogenesis
Microbiology
Diagnosis
Clinical features
Radiological diagnosis of bronchiectasis
Further investigations
Defining severity
Exacerbations in bronchiectasis
Viral and bacterial infection in exacerbations
Management
Treatment of acute exacerbations of bronchiectasis
Maintenance therapy
Vaccines
Newer treatments
Surgery
Education and management plans
Long-term prognosis
Clinics care points
Nontuberculous Mycobacteria: Diagnosis and Therapy
Key points
Background
Clinical characteristics of pulmonary nontuberculous mycobacteria disease
Nontuberculous mycobacteria diagnosis
Treatment of pulmonary nontuberculous mycobacteria disease
Induction phase
Suppressive phase
Surgery
Clinical follow-up
Clinics care points
Allergic Bronchopulmonary Aspergillosis
Key points
Introduction
Epidemiology
Microbiology
Pathogenesis
Pathology
Clinical presentation
Diagnosis of allergic bronchopulmonary aspergillosis
Diagnostic criteria
Clinical staging
Treatment
ABPA in special situations
Complications
Summary
Clinics care points
Conflicts of interest
Financial disclosures
Diagnosis of Primary Ciliary Dyskinesia
Key points
Introduction
Clinical features of primary ciliary dyskinesia
Why should we think about primary ciliary dyskinesia?
When should we think about primary ciliary dyskinesia
Role of nasal nitric oxide in diagnosis
Further diagnostic testing for primary ciliary dyskinesia
Improving primary ciliary dyskinesia diagnosis: priorities for research
Summary
Clinics care points
Supplementary data
The Spectrum of Airway Involvement in Inflammatory Bowel Disease
Key points
Dedication to:
1-Introduction
2-Literature waypoints of interest
3-Epidemiology
4-Airway involvement in inflammatory bowel disease—clinical presentations and scenarios
5-Conclusion
Clinics care points
Disclosure
Airway Clearance and Mucoactive Therapies in Bronchiectasis
Key points
Introduction
Physiology of airway clearance, mucoactive therapies, and pulmonary rehabilitation
Specific airway clearance and mucoactive therapies
Evidence of effectiveness of airway clearance and mucoactive therapies
Pulmonary rehabilitation and exercise training: modalities and effectiveness
Practical considerations in prescribing airway clearance therapies
Conclusions
Clinics care points
Disclosure
Antibiotic Management in Bronchiectasis
Key points
Introduction
Antibiotic treatment of pulmonary exacerbations
Maintenance antibiotic treatment in adults with bronchiectasis
Eradicating new growths of specific organisms in adults with bronchiectasis
Summary
Clinics care points
Future Directions in Bronchiectasis Research
Key points
Introduction
Validated biomarkers
Genetics and epigenetics
Microbiome
Other relevant omics
Personalized medicine
Summary
Clinics care points
Disclosure

Life sciences

Physical sciences & Engineering

Social sciences & Humanities

Health

Bronchiectasis, An Issue of Clinics in Chest Medicine

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James D. Chalmers