Brenner & Rector's The Kidney (2 volume set)
- 12th Edition - March 2, 2026
- Latest edition
- Editors: Valerie Luyckx, Glenn M. Chertow, Philip A. Marsden, Karl Skorecki, Maarten W. Taal, Alan S.L. Yu
- Language: English
**Selected for 2026 Doody's Core Titles in Nephrology**Long considered the definitive reference for nephrology practitioners and fellows, Brenner & Rector's The Kidney, marks… Read more
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Description
Description
**Selected for 2026 Doody's Core Titles in Nephrology**
Long considered the definitive reference for nephrology practitioners and fellows, Brenner & Rector's The Kidney, marks its 50th anniversary with the publication of this 12th Edition. This two-volume masterwork provides expert, well-illustrated information on everything from basic science and pathophysiology to clinical best practices, covering the total patient population from preconception to the elderly. More than 200 expert contributors from 20 countries representing six continents provide a truly global perspective on the treatment and management of renal diseases.
Long considered the definitive reference for nephrology practitioners and fellows, Brenner & Rector's The Kidney, marks its 50th anniversary with the publication of this 12th Edition. This two-volume masterwork provides expert, well-illustrated information on everything from basic science and pathophysiology to clinical best practices, covering the total patient population from preconception to the elderly. More than 200 expert contributors from 20 countries representing six continents provide a truly global perspective on the treatment and management of renal diseases.
Key features
Key features
- Addresses current issues such as advancements in the understanding and treatment of glomerular diseases, global considerations in treating and managing kidney disease, acute kidney injury, and kidney transplantation
- Includes new chapters on Infection-related Glomerulonephritis; IgA Nephropathy and IgA Vasculitis; Point-of-Care Ultrasound; Chronic Kidney Disease of Unknown Etiology; Kidney Lesions Associated with Dysproteinemias; Nephrotic Syndrome; Disaster Nephrology; and Sex, Gender, and Kidney Health
- Offers significantly revised content on complement-mediated GN and thrombotic microangiopathies, genetics of kidney disease, and nephrotic syndrome: primary and secondary
- Contains hundreds of full-color, high-quality photographs as well as carefully chosen figures, algorithms, and tables that illustrate essential concepts, nuances of clinical presentation and technique, and clinical decision making
- Twelve new videos included in the Point-of Care chapter provide expert guidance on technique and interpretation of findings
- Features quick reference features such as Key Points boxes in each chapter, and Clinical Relevance boxes that highlight information you must know during a patient visit, such as pertinent physiology or pathophysiology
- Includes board review-style questions to help you prepare for certification or recertification
- Offers an authoritative, international perspective from a world-renowned editor and contributor team
- Provides nephrologists, fellows, renal nurses, and other health care providers with a complete, trustworthy resource, covering basic science, pathophysiology, and diagnosis and treatment
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date
Readership
Readership
Practicing nephrologists; fellows
Table of contents
Table of contents
VOLUME 1
SECTION: NORMAL STRUCTURE AND FUNCTION
1. Embryology of the Kidney
2. Anatomy of the Kidney
3. Renal Circulation and Glomerular Filtration
4. Glomerular Cell Biology and Podocytopathies
5. Kidney Metabolism
6. Transport of Sodium, Chloride, and Potassium
7. Transport of Calcium, Magnesium, and Phosphate
8. Renal Handling of Organic Solutes
9. Renal Acidification Mechanisms
10. Urine Concentration and Dilution
11. Vasoactive Molecules and the Kidney
12. Aldosterone and Mineralocorticoid Receptors: Renal and Extrarenal Roles
SECTION II DISORDERS OF BODY FLUID VOLUME AND COMPOSITION
13. Disorders of Sodium Balance
14. Disorders of Water Balance
15. Disorders of Acid-Base Balance
16. Disorders of Potassium Balance
17. Disorders of Calcium, Magnesium, and Phosphate Balance
SECTION III EPIDEMIOLOGY AND RISK FACTORS IN KIDNEY DISEASE
18. Epidemiology of Kidney Disease
19. Risk Prediction in Chronic Kidney Disease
20. Early Life Origins of Hypertension and Chronic Kidney Disease
21. The Physiology and Pathophysiology of the Kidneys in Aging
22. Sex and Gender in Kidney Health and Disease
SECTION IV EVALUATION OF THE PATIENT WITH KIDNEY DISEASE
23. Laboratory Assessment of Kidney Disease: Glomerular Filtration Rate, Proteinuria, and Urinalysis
24. Diagnostic Kidney Imaging
25. The Renal Biopsy
26. Point-of-Care Ultrasound
SECTION V DISORDERS OF KIDNEY STRUCTURE AND FUNCTION
27. Pathophysiology of Acute Kidney Injury
28. Prevention and Management of Acute Kidney Injury
29. Pathophysiology of Proteinuria
30. Nephrotic Syndrome: Primary and Secondary
31. Lupus Nephritis and Other Kidney Manifestations of Systemic Inflammatory and Autoimmune Diseases
32. Antineutrophil Cytoplasmic Antibody–Associated Vasculitis and Antiglomerular Basement Membrane Disease
33. IgA Nephropathy and IgA Vasculitis
34. Infection-Related Glomerulonephritis
35. Kidney Lesions Associated With Dysproteinemias
36. Complement-Mediated Kidney Diseases
37. Tubulointerstitial Diseases
38. Urinary Tract Infection in Adults
39. Urinary Tract Obstruction
40. Nephrolithiasis
41. Diabetic Kidney Disease
42. Cardiovascular Disease in Persons With Chronic Kidney Disease
43. Kidney Cancer
VOLUME 2
SECTION VI GENETICS OF KIDNEY DISEASE
44. Genetics of Kidney Disease
45. Cystic Kidney Diseases
SECTION VII HYPERTENSION AND THE KIDNEY
46 Primary and Secondary Hypertension
47. Renovascular Hypertension and Ischemic Nephropathy
48. Antihypertensive Therapy
49. Diuretics
SECTION VIII CONSEQUENCES OF CHRONIC KIDNEY DISEASE
50. Mechanisms of Progression in Chronic Kidney Disease
51. The Pathophysiology of Uremia
52. Chronic Kidney Disease–Mineral Bone Disorder
53. Hematologic Aspects of Kidney Disease
SECTION IX MANAGEMENT OF CHRONIC KIDNEY DISEASE
54. Classification and Management of Chronic Kidney Disease
55. Dietary Approaches to Kidney Diseases
56. Drug Dosing Considerations in Patients With Acute Kidney Injury and Chronic Kidney Disease
57. Onconephrology: Kidney Disease and Cancer
58. Pregnancy and Kidney Disease
59. Infectious Diseases and the Kidney
60. Care of the Older Adult With Chronic Kidney Disease
61. Kidney Supportive Care in Advanced Chronic Kidney Disease
SECTION X DIALYSIS AND EXTRACORPOREAL THERAPIES
62. Hemodialysis
63. Peritoneal Dialysis
64. Critical Care Nephrology
65. Therapeutic Plasma Exchange and Other Extracorporeal Treatments in Management of Kidney and Related Diseases
66. Enhanced Elimination of Poisons
67. Interventional Nephrology: Managing Dialysis Access and Kidney Biopsy
SECTION XI KIDNEY TRANSPLANTATION
68. The Immunobiology of Transplantation
69. Clinical Management of the Adult Kidney Transplant Recipient
70. Considerations in Living Kidney Donation
SECTION XII PEDIATRIC NEPHROLOGY
71. Childhood Kidney Disease
72. Kidney Replacement Therapy (Dialysis and Transplantation) in Children
SECTION XIII GLOBAL CONSIDERATIONS IN KIDNEY DISEASE
73. Global Challenges and Progress in Kidney Health
74. Global Considerations in Kidney Disease: Latin America
75. Global Considerations in Kidney Disease: Africa
76. Global Considerations in Kidney Disease: Near and Middle East
77. Global Considerations in Kidney Disease: Indian Subcontinent
78. Global Considerations in Kidney Disease: The Far East
79. Global Considerations in Kidney Disease: The Pacific Islands and Islands of the Caribbean
SECTION XIV CHALLENGES IN NEPHROLOGY
80. Ethical Dilemmas Facing Nephrology
81. Health Disparities in Nephrology
82. Disaster Nephrology
83. Chronic Kidney Disease of Uncertain Etiology
84. Stem Cells, Kidney Regeneration, and Gene and Cell Therapy in Nephrology
SECTION: NORMAL STRUCTURE AND FUNCTION
1. Embryology of the Kidney
2. Anatomy of the Kidney
3. Renal Circulation and Glomerular Filtration
4. Glomerular Cell Biology and Podocytopathies
5. Kidney Metabolism
6. Transport of Sodium, Chloride, and Potassium
7. Transport of Calcium, Magnesium, and Phosphate
8. Renal Handling of Organic Solutes
9. Renal Acidification Mechanisms
10. Urine Concentration and Dilution
11. Vasoactive Molecules and the Kidney
12. Aldosterone and Mineralocorticoid Receptors: Renal and Extrarenal Roles
SECTION II DISORDERS OF BODY FLUID VOLUME AND COMPOSITION
13. Disorders of Sodium Balance
14. Disorders of Water Balance
15. Disorders of Acid-Base Balance
16. Disorders of Potassium Balance
17. Disorders of Calcium, Magnesium, and Phosphate Balance
SECTION III EPIDEMIOLOGY AND RISK FACTORS IN KIDNEY DISEASE
18. Epidemiology of Kidney Disease
19. Risk Prediction in Chronic Kidney Disease
20. Early Life Origins of Hypertension and Chronic Kidney Disease
21. The Physiology and Pathophysiology of the Kidneys in Aging
22. Sex and Gender in Kidney Health and Disease
SECTION IV EVALUATION OF THE PATIENT WITH KIDNEY DISEASE
23. Laboratory Assessment of Kidney Disease: Glomerular Filtration Rate, Proteinuria, and Urinalysis
24. Diagnostic Kidney Imaging
25. The Renal Biopsy
26. Point-of-Care Ultrasound
SECTION V DISORDERS OF KIDNEY STRUCTURE AND FUNCTION
27. Pathophysiology of Acute Kidney Injury
28. Prevention and Management of Acute Kidney Injury
29. Pathophysiology of Proteinuria
30. Nephrotic Syndrome: Primary and Secondary
31. Lupus Nephritis and Other Kidney Manifestations of Systemic Inflammatory and Autoimmune Diseases
32. Antineutrophil Cytoplasmic Antibody–Associated Vasculitis and Antiglomerular Basement Membrane Disease
33. IgA Nephropathy and IgA Vasculitis
34. Infection-Related Glomerulonephritis
35. Kidney Lesions Associated With Dysproteinemias
36. Complement-Mediated Kidney Diseases
37. Tubulointerstitial Diseases
38. Urinary Tract Infection in Adults
39. Urinary Tract Obstruction
40. Nephrolithiasis
41. Diabetic Kidney Disease
42. Cardiovascular Disease in Persons With Chronic Kidney Disease
43. Kidney Cancer
VOLUME 2
SECTION VI GENETICS OF KIDNEY DISEASE
44. Genetics of Kidney Disease
45. Cystic Kidney Diseases
SECTION VII HYPERTENSION AND THE KIDNEY
46 Primary and Secondary Hypertension
47. Renovascular Hypertension and Ischemic Nephropathy
48. Antihypertensive Therapy
49. Diuretics
SECTION VIII CONSEQUENCES OF CHRONIC KIDNEY DISEASE
50. Mechanisms of Progression in Chronic Kidney Disease
51. The Pathophysiology of Uremia
52. Chronic Kidney Disease–Mineral Bone Disorder
53. Hematologic Aspects of Kidney Disease
SECTION IX MANAGEMENT OF CHRONIC KIDNEY DISEASE
54. Classification and Management of Chronic Kidney Disease
55. Dietary Approaches to Kidney Diseases
56. Drug Dosing Considerations in Patients With Acute Kidney Injury and Chronic Kidney Disease
57. Onconephrology: Kidney Disease and Cancer
58. Pregnancy and Kidney Disease
59. Infectious Diseases and the Kidney
60. Care of the Older Adult With Chronic Kidney Disease
61. Kidney Supportive Care in Advanced Chronic Kidney Disease
SECTION X DIALYSIS AND EXTRACORPOREAL THERAPIES
62. Hemodialysis
63. Peritoneal Dialysis
64. Critical Care Nephrology
65. Therapeutic Plasma Exchange and Other Extracorporeal Treatments in Management of Kidney and Related Diseases
66. Enhanced Elimination of Poisons
67. Interventional Nephrology: Managing Dialysis Access and Kidney Biopsy
SECTION XI KIDNEY TRANSPLANTATION
68. The Immunobiology of Transplantation
69. Clinical Management of the Adult Kidney Transplant Recipient
70. Considerations in Living Kidney Donation
SECTION XII PEDIATRIC NEPHROLOGY
71. Childhood Kidney Disease
72. Kidney Replacement Therapy (Dialysis and Transplantation) in Children
SECTION XIII GLOBAL CONSIDERATIONS IN KIDNEY DISEASE
73. Global Challenges and Progress in Kidney Health
74. Global Considerations in Kidney Disease: Latin America
75. Global Considerations in Kidney Disease: Africa
76. Global Considerations in Kidney Disease: Near and Middle East
77. Global Considerations in Kidney Disease: Indian Subcontinent
78. Global Considerations in Kidney Disease: The Far East
79. Global Considerations in Kidney Disease: The Pacific Islands and Islands of the Caribbean
SECTION XIV CHALLENGES IN NEPHROLOGY
80. Ethical Dilemmas Facing Nephrology
81. Health Disparities in Nephrology
82. Disaster Nephrology
83. Chronic Kidney Disease of Uncertain Etiology
84. Stem Cells, Kidney Regeneration, and Gene and Cell Therapy in Nephrology
Review quotes
Review quotes
Review of the previous edition:
"The books definitely meet the needs of an audience seeking a complete and thorough nephrology reference. This is a very useful resource." -- Paul Adams, BS MD(University of Kentucky College of Medicine) Doodys Score: 95 - 4 Stars!
"The books definitely meet the needs of an audience seeking a complete and thorough nephrology reference. This is a very useful resource." -- Paul Adams, BS MD(University of Kentucky College of Medicine) Doodys Score: 95 - 4 Stars!
Product details
Product details
- Edition: 12
- Latest edition
- Published: March 17, 2026
- Language: English
About the editors
About the editors
VL
Valerie Luyckx
Valerie Luyckx is Affiliate Lecturer, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Institute of Biomedical Ethics and the History of MedicineUniversity of Zurich, Zurich, Switzerland.
Affiliations and expertise
Affiliate Lecturer, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Institute of Biomedical Ethics and the History of MedicineUniversity of Zurich, Zurich, SwitzerlandGC
Glenn M. Chertow
Glenn M. Chertow is Norman S. Coplon/ Satellite Healthcare, Professor of Medicine, Chief, Division of Nephrology at Stanford University School of Medicine, Stanford, Palo Alto, California, USA
Affiliations and expertise
Norman S. Coplon/ Satellite Healthcare, Professor of Medicine, Chief, Division of Nephrology, Stanford University School of Medicine, Stanford, Palo Alto, California, USAPM
Philip A. Marsden
Philip A. Marsden is Professor of Medicine, Elisabeth Hofmann Chair in Translational Research, Oreopoulos-Baxter Division Director of Nephrology; Vice Chair Research, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Affiliations and expertise
Professor of Medicine, Elisabeth Hofmann Chair in Translational Research, Oreopoulos-Baxter Division Director of Nephrology; Vice Chair Research, Department of Medicine, University of Toronto, Toronto, Ontario, CanadaKS
Karl Skorecki
Karl Skorecki is Annie Chutick Professor and Chair in Medicine (Nephrology), Technion-Israel Institute of Technology, Director of Medical and Research Development, Rambam Health Care Campus, Haifa, Israel.
Affiliations and expertise
Annie Chutick Professor and Chair in Medicine (Nephrology), Technion-Israel Institute of Technology, Director of Medical and Research Development, Rambam Health Care Campus, Haifa, IsraelMT
Maarten W. Taal
Professor of Medicine Maarten W. Taal works in the Division of Medical Sciences and Graduate Entry Medicine at University of Nottingham; Honorary Consultant Nephrologist, Department of Renal Medicine, Royal Derby Hospital, Derby, UK.
Affiliations and expertise
Professor of Medicine, Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham; Honorary Consultant Nephrologist, Department of Renal Medicine, Royal Derby Hospital, Derby, UKAY
Alan S.L. Yu
Alan S. L. Yu is Harry Statland and Solon Summerfield Professor of Medicine, Director, Division of Nephrology and Hypertension and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.
Affiliations and expertise
Harry Statland and Solon Summerfield Professor of Medicine, Director, Division of Nephrology and Hypertension and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA