Breast Cancer: A Multidisciplinary Approach

Clinics Collections

1st Edition, Volume 14 -1 - March 27, 2024
Editor: Joel J. Heidelbaugh
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 3 4 3 0 0 - 1
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 3 4 3 0 1 - 8

Clinics Collections: BREAST CANCER draws from Elsevier’s robust Clinics Review Articles database to provide multidisciplinary teams, including surgeons, primary care physician… Read more

Breast Cancer: A Multidisciplinary Approach

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Clinics Collections: BREAST CANCER draws from Elsevier’s robust Clinics Review Articles database to provide multidisciplinary teams, including surgeons, primary care physicians, psychiatrists, and oncologists, with practical clinical advice and insights across individual specialties.

Clinics Collections: BREAST CANCER guides readers on how to apply current best practices in the diagnosis and treatment of breast cancer to everyday practice to help overcome challenges and complications, keep up with new and advanced treatment methods, and improve patient outcomes.

Cover image
Title page
Table of Contents
Contributors
Preface
Pathology
Genetics of Breast Cancer: Risk Models, Who to Test, and Management Options
Key points
Introduction
Models: breast cancer and genetic risk
Models: breast cancer and genetic risk
Germline genetic testing
Image-based screening for breast cancer in high-risk populations
Role of risk-reducing breast surgery
Treatment of breast cancer in high-risk patients
Summary
Clinics care points
Breast Cancer Pathology in the Era of Genomics
Key points
Introduction
Germline testing
Tumor classification
Adenoid cystic carcinoma
Secretory carcinoma
Tall-cell carcinoma with reversed polarity
Adenomyoepithelioma/malignant adenomyoepithelioma
Prognostic and predictive testing
Ki67
Tumor-infiltrating lymphocytes
Treatment decisions
Immune checkpoint inhibitors and PD-L1 testing
ESR1 mutations
HER2 overexpression, amplification, and mutation
PIK3CA mutations for PI3K inhibitor treatment
Circulating tumor DNA
The utility of genomic analysis in resolving diagnostic dilemmas
Summary
Breast Cancer Screening Modalities, Recommendations, and Novel Imaging Techniques
Key points
Introduction
Discussion
Breast cancer screening recommendations for women of average risk
Breast cancer screening recommendations for high-risk women
Supplemental screening modalities
Emerging screening technologies
Summary
Clinics care points
Testing for Inherited Susceptibility to Breast Cancer
Key points
Introduction
Rare, high-penetrance variants
Rare, moderate penetrance variants
Common variation and breast cancer risk
Introduction of genetic testing for breast cancer susceptibility
Challenges to the standard model
Considerations regarding universal testing
Summary
Clinics care points
A New Landscape of Testing and Therapeutics in Metastatic Breast Cancer
Key points
Overview
Hormone receptor and human epidermal growth factor receptor-2 testing
Programmed death-ligand 1 testing for immunotherapy
Mismatch repair protein deficiency, microsatellite instability, and tumor mutation burden testing
Single-gene alteration testing for targeted therapy
Future directions
Summary
Primary Care
Individualizing Breast Cancer Risk Assessment in Clinical Practice
Key points
Introduction
Discussion
Challenges and opportunities
Summary
Clinics care points
Disclosure
Psychological Aspects of Breast Cancer
Key points
Introduction
Background
Discussion
Psychotherapeutic approaches
Summary
Clinics care points
Disclosure
Disparities in Breast Cancer Outcomes and How to Resolve Them
Key points
Breast cancer outcomes
Defining the disparities
Differences in stage at diagnosis
Molecular subtypes by race
Survival and outcomes
Incidence and mortality
Reasons for the disparities
Energy imbalance
Birthing habits
Other risk factors for breast cancer
Disparities in screening and diagnosis
Disparities in treatment
The solution: bringing about health equity
Clinics care points
Diagnosis
Breast Cancer: Risk Assessment, Screening, and Primary Prevention
Key points
Introduction
Summary
Clinics care points
Disclosure
Breast Cancer Risk Assessment and Management of the High-Risk Patient
Key points
Breast cancer risk assessment
Management of the high-risk patient
Summary
Clinics care points
Disclosure
Advances in Breast Imaging with Current Screening Recommendations and Controversies
Key points
Introduction
Breast cancer screening
Diagnostic breast imaging
Breast imaging procedures
Clinics care points
Molecular Breast Imaging and Positron Emission Mammography
Key points
Introduction
Molecular breast imaging
Positron emission mammography
Summary
Clinics care points
Disclosure
Treatment
Incorporating Value-Based Decisions in Breast Cancer Treatment Algorithms
Key points
Introduction: defining “value” in breast cancer care
Improving value-based decisions in screening and diagnostics
Improving value-based decisions in breast surgical oncology
Improving value-based decisions in medical oncology
Improving value-based decisions in radiation oncology
Improving value-based decisions in postcancer surveillance
Summary
Clinics care points
Disclosures
Multidisciplinary Management of Breast Cancer and Role of the Patient Navigator
Key points
Modern breast cancer care: An introduction
Comprehensive breast center
Multidisciplinary team
Breast radiology
Medical oncology
Radiation oncology
Pathology
Surgery
Oncology patient navigators
Survivorship
Genetic counselors
Tumor board, cancer research, and tumor registry
Fertility
Sexual health
Ancillary support services
Complementary therapies
Summary
Clinics care points
Addressing Inequalities in Breast Cancer Care Delivery
Key points
Introduction/history/definitions/background
Discussion
Summary
Disclosures
Evaluation of Treatment Response in Patients with Breast Cancer
Key points
Introduction
Neoadjuvant therapy response assessment
Anatomic imaging techniques
Metastatic breast cancer therapy response assessment
Other FDA-approved radionuclides
Summary
Clinics care points
Disclosure
Chemotherapy
Adjuvant Systemic Therapy for Postmenopausal, Hormone Receptor-Positive Early Breast Cancer
Key points
Introduction
Prognostic factors and assessing risk of recurrence
Adjuvant endocrine therapy in postmenopausal hormone receptor-positive early breast cancer
Adjuvant chemotherapy in postmenopausal hormone receptor-positive early breast cancer
Additional adjuvant systemic therapies in higher-risk hormone receptor-positive early breast cancer
Future directions for adjuvant systemic therapies in hormone receptor-positive early breast cancer
Summary
Clinics care points
Disclosure
Role of Immunotherapy in Early- and Late-Stage Triple-Negative Breast Cancer
Key points
Introduction
Discussion
Summary
Clinics care points
Disclosure
Funding
Surgical Treatment
Postoperative Complications from Breast and Axillary Surgery
Key points
Introduction
Early complications
Seroma
Infection
Skin flap necrosis
Nipple and nipple–areolar complex necrosis
Venous thromboembolism
Nerve injury and postoperative pain
Brachial plexopathy
Long-term complications
Axillary web syndrome
Secondary angiosarcoma
Delayed breast reconstruction-related complications
Psychosocial impacts of breast surgery
Clinics care points
Novel Approaches to Breast Reconstruction
Key points
Introduction
Clinics care points
Modern Approaches to Implant-Based Breast Reconstruction
Key points
Introduction
Modern approach to mastectomy
Modern implant choices
Support materials in implant reconstruction
Summary
Clinics care points
Disclosure
Prepectoral Breast Reconstruction
Key points
Introduction
Preoperative considerations
Intraoperative techniques
Postoperative considerations and complications
Summary
Clinics care points
Financial disclosure statement
Modern Approaches to Pedicled Latissimus Dorsi Flap Breast Reconstruction with Immediate Fat Transfer
Key points
Introduction
Patient selection and preoperative counseling
Surgical technique
Discussion
Case demonstration
Summary
Clinics care points
Disclosure
Modern Approaches to Abdominal-Based Breast Reconstruction
Key points
Introduction
Patient selection and considerations
Discussion
Summary
Clinics care points
Disclosure
Radiation Treatment
Radiation Treatment for Breast Cancer
Key points
Introduction
Radiation treatment overview and techniques
Radiation treatment in the nonmetastatic setting
Toxicities/contraindications
Summary
Clinics care points
Quality of Life
Quality of Life Issues Following Breast Cancer Treatment
Key points
Introduction
Summary
Evidence-Based Guidance for Breast Cancer Survivorship
Key points
Introduction to breast cancer survivorship
Management of symptoms related to cancer-directed therapy
Mental health concerns
Health and wellness promotion
Financial toxicity
Second cancer screening
Surveillance for breast cancer recurrence
Reproductive concerns
Cardiac/other health concerns
Osteoporosis
Disparities in survivorship
Clinics care points
Fertility and Sexual Health in Young Women with Early-Stage Breast Cancer
Key points
Introduction
From the start: pre-therapy considerations
In the thick of it: management during adjuvant treatment
Life After Treatment: Post-Therapy Considerations
Clinics care points
Funding
Disclosures

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