Brain Plasticity and Epilepsy: A Tribute to Frank Morrell

1st Edition - November 13, 2000

Editors: Ronald J. Bradley, Jerome Engel Jr., Robert Adron Harris, Philip A. Schwartzkroin, Peter Jenner, Solomon L. Moshé, Daniel H. Lowenstein

eBook ISBN:

9 7 8 - 0 - 0 8 - 0 5 7 4 2 2 - 6

This volume of International Review of Neurobiology integrates the latest developments in normal and abnormal neuroplasticity and epilepsy, and considers their implications for… Read more

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This volume of International Review of Neurobiology integrates the latest developments in normal and abnormal neuroplasticity and epilepsy, and considers their implications for understanding the basic mechanisms of normal and pathological behaviors. The chapters are written by leaders in the field, and provide comprehensive coverage of the subject, from molecular neurobiology to behavior. This book will help neuroscientists gain a better understanding of the application of fundamental neuronal mechanisms of plastic change to problems relevant to the diagnosis, treatment, and prevention of human disease, particularly epilepsy.

Contributors.
Preface.
Acknowledgements.
Mechanisms of Brain Plasticity: From Normal Brain Function to Pathology, P.A. Schwartzkroin.
Brain Development and Generation of Brain Pathologies, G.L. Holmes and B. McCabe.
Maturation of Channels and Receptors: Consequences for Excitability, D.F. Owens and A.R. Kriegstein.
Neuronal Activity and the Establishment of Normal and Epileptic Circuits during Brain Development, J.W. Swann, K.L. Smith, and C.L. Lee.
The Effects of Seizures on the Hippocampus of the Immature Brain, E.F. Sperber and S.L. Moshé.
Abnormal Development and Catastrophic Epilepsies: the Clinical Picture and Relation to Neuroimaging, H.T. Chugani and D.C. Chugani.
Cortical Reorganization and Seizure Generation in Dysplastic Cortex, G. Avanzini, R. Spreafico, S. Franceschetti, G. Sancini, G. Battaglia, and V. Sciaoli.
Rasmussen's Syndrome with Particular Reference to Cerebral Plasticity: A Tribute to Frank Morrell, F. Andermann and Y. Hart.
Structural Reorganization of Hippocampal Networks Caused by Seizure Activity, D.H. Lowenstein.
Epilepsy-Associated Plasticity in g-Aminobutyric Acid Receptor Expression, Function, and Inhibitory Synaptic Properties, D.A. Coulter.
Synaptic Plasticity and Secondary Epileptogenesis, T.J. Teyler, S.L. Morgan, R.N. Russell, and B.L. Woodside.
Synaptic Plasticity in Epileptogenesis: Cellular Mechanisms Underlying Long-Lasting Synaptic Modifications That Require New Gene Expression, O. Steward, C.S. Wallace, and P.F. Worley.
Cellular Correlates of Behavior, E.R. Wood, P.A. Dudchenko, and H. Eichenbaum.
Mechanisms of Neuronal Conditioning, D.A.T. King, D.J. Krupa, M.R. Foy, and R.F. Thompson.
Plasticity in the Aging Central Nervous System, C.A. Barnes.
Secondary Epileptogenesis, Kindling, and Intractable Epilepsy: A Reappraisal from the Perspective of Neural Plasticity, T.P. Sutula.
Kindling and the Mirror Focus, D.C. McIntyre and M.O. Poulter.
Partial Kindling and Behavioral Pathologies, R.E. Adamec.
The Mirror Focus and Secondary Epileptogenesis, B.J. Wilder.
Hippocampal Lesions in Epilepsy: A Historical Review, R. Naquet.
Clinical Evidence for Secondary Epileptogenesis, H.O. Lüders.
Epilepsy as a Progressive (or Nonprogressive "Benign") Disorder, J.A. Wada.
Pathophysiological Aspects of Landau-Kleffner Syndrome: From the Active Epileptic Phase to Recovery, M.-N. Metz-Lutz, P. Maquet, A. De Saint Martin, G. Rudolf, N. Wioland, E. Hirsch, and C. Marescaux.
Local Pathways of Seizure Propagation in Neocortex, B.W. Connors, D.J. Pinto, and A.E. Telfeian.
Multiple Subpial Transection: A Clinical Assessment, C.E. Polkey.
The Legacy of Frank Morrell, J. Engel, Jr.
Index.

Ronald J. Bradley

Affiliations and expertise

Louisiana State University Medical Center, School of Medicine, Baton Rouge, U.S.A.

Jerome Engel Jr.

Affiliations and expertise

UCLA School of Medicine, Los Angeles, California, U.S.A.

Robert Adron Harris

Affiliations and expertise

University of Texas, Austin, U.S.A.

Philip A. Schwartzkroin

Affiliations and expertise

University of California, Davis, USA

Peter Jenner

Professor Peter Jenner is a specialist in preclinical aspects of neurodegenerative diseases, notably Parkinson’s disease. He has spent the major part of his career at King’s College London where he was Head of Pharmacology for 14 years before returning to his research roots and subsequently becoming Emeritus Professor of Pharmacology. Peter has expertise in drug metabolism and pharmacokinetics but neuropharmacology based on functional models of neurodegenerative diseases has formed the major focus of his work. Peter holds a BPharm, PhD and DSc degree from the University of London. He has published well over 1000 articles with more than 700 peer reviewed papers. He is a Fellow of the Royal Pharmaceutical Society, the British Pharmacological Society, the Royal Society of Medicine and of King’s College London. Peter was recently honoured with a Doctor Honoris Causa degree from Carol Davila University of Medicine and Pharmacy, Bucharest and made an Honorary Fellow of The British Pharmacological Society for his contribution to research in to movement disorders. Peter has worked closely with the pharmaceutical industry for many years and acts as an adviser and consultant to both major pharma and biotech companies. He has a wide knowledge of the drug discovery and drug development process and has been involved from molecule synthesis through to drug registration for use in man. Peter was the Founder, Director and Chief Scientific Officer of Proximagen, a biotech focussed on the treatment and cure of neurodegenerative diseases that was listed on AIMs and subsequently purchased by a US based healthcare company. He is a regular speaker at international meetings and also takes time to speak at Parkinson’s disease patient-carer groups across the UK.

Affiliations and expertise

Emeritus Professor of Pharmacology, Institute of Pharmaceutical Sciences, King’s College London, London, UK

Solomon L. Moshé

Dr. Moshé is the is the Charles Frost Chair in Neurosurgery and Neurology and Professor of Neurology, Neuroscience, and Pediatrics at Albert Einstein College of Medicine. He is the Director of Child Neurology and Clinical Neurophysiology Dr. He has been President of the International League Against Epilepsy, American Epilepsy Society and American Clinical Neurophysiology Society (1996-1997). He is the recipient of several honors and awards, including Teacher-Investigator Development Award; Jacob Javits Neuroscience Investigator Award from NIH; Michael Prize for Achievement in Epilepsy Research; The American Epilepsy Society Research Award; Ambassador for Epilepsy Award from the International League Against Epilepsy; the Gloor Award from the American Clinical Neurophysiology Society; J.E. Purkyne Honorary Medal in Biomedical Research by the Czech Academy of Sciences; the 2008 Mentor of the Year Award from Albert Einstein College of Medicine; The 2010 Global and Awareness Award from Citizens United for Research in Epilepsy; the First Saul R. Korey Award in Translational Science and Medicine, Albert Einstein College of Medicine in 2012; elected Foreign Member of the Russian Academy of Sciences and Fellow of the American Epilepsy Society 2016. Since 1979, his research has focused on understanding the mechanisms underlying age-related differences in epilepsy in humans and in animal models.

Affiliations and expertise

Albert Einstein College of Medicine, Bronx, NY, USA

Daniel H. Lowenstein

Affiliations and expertise

Harvard Medical School, Boston, Massachusetts, U.S.A.