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Boron Nitride Nanotubes in Nanomedicine
- 1st Edition - April 19, 2016
- Editors: Gianni Ciofani, Virgilio MATTOLI
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 3 8 9 4 5 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 3 8 9 6 0 - 0
Boron Nitride Nanotubes in Nanomedicine compiles, for the first time in a single volume, all the information needed by researchers interested in this promising type of smart nan… Read more
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compiles, for the first time in a single volume, all the information needed by researchers interested in this promising type of smart nanoparticles and their applications in biomedicine. Boron nitride nanotubes (BNNTs) represent an innovative and extremely intriguing class of nanomaterials.After introducing BNNTs and explaining their preparation and evaluation, the book shows how the physical, chemical, piezoelectric and biocompatibility properties of these nanotubes give rise to their potential uses in biomedicine. Evidence is offered (from both in vitro and in vivo investigations) for how BNNTs can be useful in biomedical and nanomedicine applications such as therapeutic applications, tissue regeneration, nanovectors for drug delivery, and intracellular nanotransducers.
- Covers a range of promising biomedical BNNT applications
- Provides great value not just to academics but also industry researchers in fields such as materials science, molecular biology, pharmacology, biomedical engineering, and biophysical sciences
- Offers evidence for how BNNTs can be useful in biomedical and nanomedicine applications such as therapy, tissue regeneration, nanovectors for drug delivery, and intracellular nanotransducers
- Incorporates, for the first time in a single volume, all the information needed by researchers interested in this promising type of smart nanoparticles and their applications in biomedicine
Foreword
Giorgia Pastorin
1. Introduction to Boron Nitride Nanotubes: Synthesis, Properties, Functionalization, and Cutting
Shiva Bhandari, Bishnu Tiwari, Nazmiye Yapici, Dongyan Zhang, Yoke Khin Yap
1.1 Introduction
1.2 Properties of BNNTs for Potential Biomedical Applications
1.3 Synthesis of BNNTs
1.3.1 Chemical Vapor Deposition
1.3.2 Ball Milling
1.3.3 Laser-Based Techniques
1.3.4 Large-Scale Synthesis by Plasma-Based Techniques
1.4 Comparison of Production Rate, Purity, and Dispersibility of BNNTs
1.5 Functionalization and Cutting of BNNTs for Biomedical Applications
1.5.1 Noncovalent Functionalization
1.5.2 Covalent Functionalization
1.6 Summary
Acknowledgments
References
2. Functionalization of Boron Nitride Nanotubes for Applications in Nanobiomedicine
Zhenghong Gao, Chunyi Zhi, Yoshio Bando, Dmitri Golberg, Takeshi Serizawa
2.1 Introduction
2.2 Covalent Functionalization
2.2.1 Nitrogen Site Reaction
2.2.2 Boron Site Reaction
2.3 Noncovalent Functionalization
2.3.1 Small Molecules with Aromatic Groups
2.3.2 Small Molecules without Aromatic Groups
2.3.3 Amino Acids
2.3.4 Surfactants
2.3.5 Peptides
2.3.6 Deoxyribonucleic Acids (DNA)
2.3.7 Lipids
2.3.8 Polysaccharides
2.3.9 Polymers
2.4 Defect Reaction Approach
2.5 Filling BNNTs Approach
2.6 Conclusions and Perspectives
References
3 Biocompatibility Evaluation of Boron Nitride Nanotubes
Özlem Şen, Melis Emanet, Mustafa Çulha
3.1 Introduction
3.2 Common Methods for Evaluating in Vitro Biocompatibility
3.2.1 Viability and Cytotoxicity Assays
3.2.2 ROS Detection
3.2.3 Apoptosis and Necrosis Detection
3.2.4 Genotoxicity Assessment
3.3 In Vitro Biocompatibility Assessment
3.4 In Vivo Biocompatibility Assessment
3.5 Future Studies and Perspectives
3.6 Conclusions
References
4 Theoretical Investigations of Interactions Between Boron Nitride Nanotubes and Drugs
Ehsan Shakerzadeh
4.1 Introduction
4.2 Density Functional Theory Methods
4.3 BNNTs/Biomolecules Interactions
4.3.1 BNNTs and Platinum-Based Drugs
4.3.2 BNNTs and Heterocyclic Compound
4.3.3 BNNTs and Other Clinically-Relevant Molecules
4.3.4 BNNTs and Amino Acids
4.4 Conclusions
References
5 Boron Nitride Nanotubes as Drug Carriers
Xia Li, Dmitri Golberg
5.1 Introduction
5.2 Improving the Dispersibility of BNNT-Based Drug Carriers
5.2.1 Oxidation Method
5.2.2 Polymer Surface Modifi cation Method
5.2.3 Plasma Treatment
5.2.4 Mesoporous Silica Coating Method
5.3 Various Drug Molecules Loaded onto BNNT-Based Drug Carriers
5.3.1 DNA
5.3.2 Proteins
5.3.3 Flavin Mononucleotide
5.3.4 Chemotherapy Drugs
5.4 Interactions Between BNNTs and Drug Molecules
5.4.1 Weak Interactions
5.4.2 Covalent Interactions
5.5 Integration of Multifunctional Properties in BNNT-Based Drug Carriers
5.5.1 Targeting Release
5.5.2 Imaging
5.5.3 Acting as B Carrier for Boron Neutron Capture Therapy
5.6 Biocompatibility, Distribution, and Excretion of BNNTs as Drug Carriers
5.7 Future of BNNTs as Drug Carriers
References
6 Applications and Perspectives of Boron Nitride Nanotubes in Cancer Therapy
Tiago Hilario Ferreira, Edesia M.B. de Sousa
6.1 Cancer: Aspects of Diagnosis and Treatment
6.2 Boron Nitride Nanotubes and Nanomedicine
6.3 Drug Delivery
6.4 Active Targeting and Uptake
6.5 Gene Transfection
6.6 Magnetohyperthermia
6.7 Boron Neutron Capture Therapy
6.8 Perspectives
References
7 Boron Nitride Nanotubes as Magnetic Resonance Imaging Contrast Agents
Lucia Calucci, Claudia Forte
7.1 Nanomaterials: The Way to Higher Magnetic Resonance Contrast
7.2 Superparamagnetic BNNTs as T2-Weighted Contrast Agents
7.3 Gd-Doped BNNTs: Promising Contrast Properties at High and Low Fields
7.4 Conclusions and Perspectives
7.5 Appendix. MRI Contrast Enhancement: The Basics
References
8 Boron Nitride Nanotubes as Nanotransducers
Serena Danti
8.1 Introduction
8.2 BNNT Nanotransducers
8.2.1 Piezoelectric Nanotransducers
8.2.2 BNNTs as Piezoelectric Transducers
8.2.3 BCN-NT Nanotransducers
8.3 BNNT Bionanotransducers
8.3.1 Ultrasound—BNNT Systems for Cell Stimulation
8.3.2 BNNT Nanotransducers for the Nervous System
8.3.3 BNNT Nanotransducers for Muscle
8.3.4 BNNT Nanotransducers for Bone
8.4 Conclusions and Future Perspectives
Acknowledgement
References
9 Optical Properties of Boron Nitride Nanotubes:Potential Exploitation in Nanomedicine
Vincenzo Piazza, Mauro Gemmi
9.1 Introduction
9.2 Optical Properties of Boron Nitride Nanotubes
9.3 Boron Nitride Nanotubes in Nanomedicine
9.4 BNNT Nonlinear Optical Properties : Exploitation in Nanomedicine
9.5 Conclusions
References
10 Boron Nitride Nanotubes as Bionanosensors
Sondipon Adhikari
10.1 Introduction
10.2 Vibration Analysis of BNNTs with Attached Mass
10.2.1 Cantilevered BNNT with a Mass at the Tip
10.2.2 Bridged BNNT with a Mass at the Midpoint
10.3 Mass Detection and Sensitivity Calculation
10.4 Vibrational Analysis of BNNTs Using Molecular Mechanics
10.5 Results and Discussions
10.6 Conclusions
References
11 Boron Nitride Nanotube Films: Preparation, Properties, and Implications for Biology Applications
Lu Hua Li, Ying Chen
11.1 Introduction
11.2 Growth of BNNT Films
11.2.1 Boron Ink Method
11.2.2 Vapor Deposition Method
11.3 Wettability Properties of BNNT Films
11.4 Wettability Modifi cation of BNNT Films
11.5 Biocompatibility of BNNT Films
11.6 Conclusion
References
12 Structural and Physical Properties of Boron Nitride Nanotubes and Their Applications in Nanocomposites
Xiaoming Chen, Changhong Ke
12.1 Introduction
12.2 Structure and Synthesis of BNNTs 12.2.1 Structure of BNNTs
12.2.2 Synthesis of BNNTs
12.3 Physical Properties of BNNTs
12.3.1 Mechanical Properties
12.3.2 Electrical Properties
12.3.3 Thermal Properties
12.4 BNNT-Based Nanocomposites
12.5 Conclusions and Outlook
Acknowledgments
References
13 Boron Nitride Nanotubes in Nanomedicine: Historical and Future Perspectives
Giada Graziana Genchi, Antonella Rocca, Agostina Grillone, Attilio Marino,Gianni Ciofani
13.1 A Brief History of Boron Nitride Nanotubes: From the Theoretical Hypothesis to the Market
13.2 Main Research Groups Involved in BNNT Research
13.3 BNNT Availability on the Market
13.4 Patent Analysis and Economical Implications
13.5 Toward the Future : Regulatory Aspects and Translational Research
References
Subject Index
- No. of pages: 246
- Language: English
- Edition: 1
- Published: April 19, 2016
- Imprint: William Andrew
- Hardback ISBN: 9780323389457
- eBook ISBN: 9780323389600
GC
Gianni Ciofani
VM