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Blood-Brain Barrier
- 1st Edition, Volume 126 - July 17, 2024
- Editor: Gerald Litwack
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 4 0 4 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 4 0 5 - 4
Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of… Read more
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Request a sales quoteVitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
- Provides the latest information on blood-brain barrier research
- Offers outstanding and original reviews on a range ofblood-brain barrier research topics
- Serves as an indispensable reference for researchers and students alike
Undergraduates, graduates, academics, and researchers in the field of Vitamins and Hormones
- Cover image
- Title page
- Table of Contents
- Editorial Board
- Copyright
- Former Editors
- Contributors
- About the editor
- Chapter One: Neurotoxic effects of metals on blood brain barrier impairment and possible therapeutic approaches
- Abstract
- Abbreviations
- 1 Introduction
- 2 Mechanisms by which heavy metals transverse the BBB
- 3 Effect of heavy metals on BBB integrity
- 4 Heavy metals induced neurotoxicity in the brain and its clinical manifestations
- 5 Potential strategies for alleviating heavy metal induced damage
- 6 Conclusion
- References
- Chapter Two: Brain microvascular endothelial cell metabolism and its ties to barrier function
- Abstract
- 1 Introduction and brain microvascular endothelial cell metabolism overview
- 2 BMEC support brain metabolism
- 3 BMEC metabolism impacts barrier integrity and cerebral function
- 4 In vitro, in vivo, and computational BMEC metabolic measurements and models
- 5 BMEC metabolic dysfunction in aging and disease
- 6 Emerging topics
- 7 Conclusions and key takeaways
- References
- Chapter Three: Sleep loss impairs blood-brain barrier function: Cellular and molecular mechanisms
- Abstract
- 1 Sleep
- 2 Sleep regulates the neurovascular unit and blood-brain barrier function
- 3 Sleep and the glymphatic system
- 4 Conclusion
- Funding
- References
- Chapter Four: Roles of astrocytic sonic hedgehog production and its signal for regulation of the blood-brain barrier permeability
- Abstract
- 1 Introduction
- 2 Shh signal in brain disorders
- 3 Neuroprotective effects of Shh
- 4 Regulation of the BBB function by astrocytic Shh production
- 5 Regulation of the BBB function by Shh signal in astrocytes
- 6 Shh-mediated BBB protection as a therapeutic target for brain damage
- 7 Conclusions and future directions
- Acknowledgments
- References
- Chapter Five: Insulin receptor at the blood–brain barrier: Transport and signaling
- Abstract
- 1 Insulin and the blood–brain barrier
- 2 Insulin receptor and BBB transport
- 3 Insulin receptor as a brain drug delivery target
- 4 BBB signaling via the insulin receptor
- 5 Conclusions and future directions
- Acknowledgments
- References
- Chapter Six: Beta-caryophyllene in psychiatric and neurological diseases: Role of blood-brain barrier
- Abstract
- 1 Beta-caryophyllene as a molecule of interest
- 2 Beta-caryophyllene and psychiatric disorders
- 3 Beta-caryophyllene and pain
- 4 Beta-caryophyllene and addiction
- 5 Beta-caryophyllene and neurodegenerative diseases
- 6 Beta-caryophyllene and ischemia
- 7 Beta-caryophyllene and epilepsy
- 8 Beta-caryophyllene and the blood-brain barrier
- 9 Conclusions and future directions
- Acknowledgments
- References
- Chapter Seven: Insulin and the blood–brain barrier
- Abstract
- 1 Introduction
- 2 Insulin
- 3 Insulin interactions at the BBB
- 4 Insulin transport at the BBB
- 5 Insulin signaling at the BBB
- 6 Future directions
- Acknowledgements
- References
- Chapter Eight: Gene therapy targeting the blood-brain barrier
- Abstract
- 1 Viral and non-viral vectors to target the blood-brain barrier
- 2 Adeno-associated viral vectors
- 3 Strategies to improve the tropism of adeno-associated viral vectors for the blood-brain barrier
- 4 Therapeutic use of gene therapy targeting the blood-brain barrier
- 5 Conclusions and perspectives
- References
- Chapter Nine: Sensors for blood brain barrier on a chip
- Abstract
- 1 Introduction
- 2 Current BBB experimental models
- 3 Application of BBB experimental models
- 4 Current detection methods used for BBB models
- 5 Implementation of sensors and biosensors in BBB models
- 6 Current implementations of sensors and biosensors on in vitro models
- 7 Conclusion and future outlook
- References
- Chapter Ten: A circadian clock regulates the blood-brain barrier across phylogeny
- Abstract
- 1 Blood-brain barrier (BBB)
- 2 Circadian clock
- 3 Temporal regulation of the BBB
- 4 Chronotherapy
- 5 Conclusion
- Acknowledgments
- References
- No. of pages: 302
- Language: English
- Edition: 1
- Volume: 126
- Published: July 17, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443194047
- eBook ISBN: 9780443194054
GL
Gerald Litwack
Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)
Affiliations and expertise
Emeritus Founding Chair and Professor, Geisinger Commonwealth School of Medicine, United States
Emeritus Professor, Rutgers University, United States