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Bland and Copeland's The Breast
Comprehensive Management of Benign and Malignant Diseases
- 6th Edition - March 18, 2023
- Authors: Kirby I. Bland, Edward M. Copeland, V. Suzanne Klimberg, William J Gradishar
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 3 3 6 5 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 8 6 2 2 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 3 3 6 6 - 0
Multidisciplinary in scope and fully up to date with the latest advances in medical oncology and more, Bland and Copeland's The Breast, 6th Edition, covers every clinically… Read more
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Request a sales quoteMultidisciplinary in scope and fully up to date with the latest advances in medical oncology and more, Bland and Copeland's The Breast, 6th Edition, covers every clinically relevant aspect of the field: cancer, congenital abnormalities, hormones, reconstruction, anatomy and physiology, benign breast disease, and more. In a practical, easy-to-use format ideal for today’s busy practitioners, this truly comprehensive resource is ideal for surgical oncologists, breast surgeons, general surgeons, medical oncologists, and others who need to stay informed of the latest innovations in this complex and fast-moving area.
Offers the most comprehensive, up-to-date information on the diagnosis and management of, and rehabilitation following, treatment for benign and malignant diseases of the breast.
Updates include an extensively updated oncoplastic section and extended medical and radiation oncology sections.
Delivers step-by-step clinical guidance highlighted by hundreds of superb illustrations that depict relevant anatomy and pathology, as well as medical and surgical procedures.
Reflects the collaborative nature of diagnosis and treatment among radiologists, pathologists, breast and plastic surgeons, radiation and medical oncologists, geneticists and other health care professionals who contribute to the management of patients with breast disease.
Includes access to procedural videos that provide expert visual guidance on how to execute key steps and techniques.
An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Surgical oncologists; breast surgeons; general surgeons; medical oncologists
- Cover image
- Title page
- Table of Contents
- Any screen, Any time, Anywhere
- Copyright
- Dedicated
- Contributors
- Preface
- Acknowledgments
- Video Contents
- Section I: History of the Therapy of Breast Cancer
- 1. The History of the Therapy for Breast Cancer
- Non-Print Item Abstract
- Ancient Civilizations
- Cultural and Religious Influences of the 2nd to 15th Centuries
- Scientific Progress of the Renaissance Period (14th–16th Century)
- 18th Century
- Uniform Withdrawal of Breast Therapy (Late 18th–Early 19th Centuries)
- 19th Century
- 20th Century Progress for Breast Cancer: An Appreciation for Evolving Concepts Formetastases
- Origins of Adjuvant Breast Cancer Therapy
- 20th and 21st Century Discovery with Integration of Pathology, Genomics, Immunochemistry: Evolution of the Breastcancer Subtypes
- Selected References
- References
- 2. History of Surgical Clinical Trials and Cooperative Group Trials
- Abstract
- Introduction
- Breast Surgical Management
- Surgical Management of the Axilla
- Selected References
- References
- 3. Important Trials of the Last Decade
- Abstract
- Trials Evaluating Deescalation of Chemotherapy
- Optimization of Neoadjuvant Therapy
- Optimizing Endocrine Therapy for HR+ Disease
- Incorporation of Immunotherapy
- Targeting Germline and Somatic Gene Mutations
- New Paradigms for HER2+ Disease
- Conclusion
- Selected References
- References
- Section II: Anatomy and Physiology of the Normal and Lactating Breast
- 4. Anatomy of the Breast, Axilla, Chest Wall, and Related Metastatic Sites
- Abstract
- Gross Anatomic Structure: Surface Anatomy
- Microscopic Anatomic Structure
- Lymphatic Drainage of the Breast
- Selected References
- References
- 5. Breast Physiology: Normal and Abnormal Development and Function
- Abstract
- Embryology to Childhood
- Puberty
- Pregnancy
- Lactation
- Regulatory Factors and Potential Genes
- Menopause
- Acknowledgment
- Selected References
- References
- 6. Discharges and Secretions of the Nipple
- Abstract
- Introduction and Definitions
- Clinical Evaluation and Management of the Patient with Nipple Discharge
- Diagnosis and Surgical Intervention
- Conclusion
- Selected References
- References
- Section III: Natural History, Epidemiology, Genetics, and Syndromes of the Breast
- 7. Epidemiology of Breast Cancer
- Abstract
- Descriptive Epidemiology
- Traditional Risk Factors for Breast Cancer
- Other Risk Factors for Breast Cancer
- Summary of Risk Factors for Breast Cancer
- Selected References
- References
- 8. Carcinogenesis of Breast Cancer
- Abstract
- Introduction
- Hormones in Breast Carcinogenesis
- Genes Involved in the Development of Breast Cancer
- Epigenetics in Breast Cancer
- Conclusion
- Selected References
- References
- 9. Risk Reduction for Developing Breast Cancer
- Abstract
- Identifying Women at Risk
- Chemoprevention
- Chemoprevention Risk Reduction Trials
- Overall Risk of Developing Invasive Breast Cancer in Women with Atypical Hyperplasia
- Low-Dose Tamoxifen in Breast Intraepithelial Neoplasia
- Clinical Data with Raloxifene
- Study of Tamoxifen and Raloxifene Trial
- Aromatase Inhibitors
- Expert Recommendations on the Use of Pharmacologic Interventions for Breast Cancer Risk Reduction
- Summary
- Selected References
- References
- 10. Breast Cancer Genetics: Syndromes, Genes, Pathology, Counseling, Testing, and Treatment
- Abstract
- Introduction
- Genetic Testing Technology
- Managing Cancer Risk
- Managing Cancer in Mutation Carriers
- The Syndromes
- Selected References
- References
- Section IV: Screening and Diagnosis of the Breast Patient
- 11. Clinical Encounter With the Patient
- Abstract
- Breast Self-Awareness and Breast Self-Examination
- The Clinical Encounter: Clinical Breast Exam
- The Clinical Encounter: Risk Assessment and Risk Reduction
- The Clinical Encounter: Imaging Modalities and Considerations
- Following the Clinical Encounter: Invasive Diagnostic Procedures
- Conclusion
- Selected References
- References
- 12. Breast Cancer Screening
- Abstract
- History of Breast Cancer Screening
- Principles of Mammography
- Screening Mammography Report
- Screening Breast Ultrasound
- Screening Magnetic Resonance Imaging (MRI)
- Contrast-Enhanced Mammography (CEM)
- Mammography Screening Trials
- Quality Assurance and Auditing
- Screening Recommendations
- The Future of Breast Cancer Screening
- Selected References
- References
- 13. Breast Cancer Diagnosis and Techniques for Biopsy
- Abstract
- Diagnostic Breast Imaging
- Financial Considerations of Diagnostic Imaging
- Stereotactic Core Needle Biopsy and Tomosynthesis Core Needle Biopsy
- Open Surgical Biopsy
- Conclusion
- Acknowledgment
- Selected References
- References
- Section V: Benign and Premalignant Lesions
- 14. Etiology and Management of Benign Breast Disease
- Abstract
- Breast Pain
- Benign Breast Disorders
- Selected References
- References
- 15. Mastitis and Breast Abscess
- Abstract
- Mastitis
- Lactational Mastitis and Abscess
- Periductal Abscess/Chronic Subareolar Abscess
- Idiopathic Granulomatous Mastitis
- Tuberculous Mastitis
- Selected References
- References
- 16. Gynecomastia
- Abstract
- Prevalence
- Clinical Presentation
- Physiology
- Anatomy
- Histopathology
- Pathophysiology
- Management of Gynecomastia
- Summary
- Selected References
- References
- 17. High-Risk and Premalignant Lesions of the Breast
- Abstract
- Introduction
- Classic High-Risk Lesions
- Surgical Excision of High-Risk Lesions
- Percutaneous Biopsy Concordance Assessment
- Description of ADH, ALH, and LCIS
- Upgrade After Percutaneous Biopsy
- Atypical Hyperplasia and LCIS: Long-Term Risk
- Risk Prediction and Prevention Therapy for Management of AH and LCIS
- Pleomorphic Lobular Carcinoma in Situ
- Summary
- Selected References
- References
- Section VI: Pathology of Malignant Lesions
- 18. Disorders of the Skin
- Abstract
- Introduction
- Inflammatory Disorders
- Genodermatoses
- Immune-Mediated Disorders
- Infectious Diseases
- Other
- Neoplasms
- Melanocytic Neoplasms
- Selected References
- References
- 19. Ductal Carcinoma In Situ
- Abstract
- Introduction
- Recent Insights into the Unique Biology of Ductal Carcinoma in Situ, Lobular Carcinoma in Situ, and Related Entities
- Pathology and Classification of Ductal Carcinoma in Situ
- Cystic Hypersecretory Carcinoma
- Extent of Disease
- Margin Status
- Risks of Evolution and Recurrence from Ductal Carcinoma in Situ
- Mammographic Correlation
- Acknowledgments
- Selected References
- References
- 20. Infiltrating Carcinomas of the Breast
- Abstract
- Introduction
- Macroscopic Findings
- Histologic Grade
- Molecular Subtyping and Histologic Features
- Invasive Breast Carcinoma, Luminal a (IBCS)
- Histopathologic Patterns Seen in Luminal B IBCS
- Invasive Mammary Carcinoma, HER2 Positive (HR+ or HR−)
- Invasive Mammary Carcinoma, Triple-Negative Breast Cancer (TN IBCS)
- Conclusion
- Selected References
- References
- 21. Biomarkers
- Abstract
- Introduction
- Estrogen Receptor: Historical Perspective
- Progesterone Receptor: Historical Perspective
- Receptor Status Assessment: Why is it Important?
- Hormone Receptor Assessment
- ER Low Positive Breast Cancers
- Repeat Immunohistochemical Studies on Recurrent and Metastatic Disease
- Commonly Used Monoclonal Antibodies
- Human Epidermal Growth Factor Receptor 2 (HER2)
- Standard Practice
- KI67 (Proliferation Marker)
- Programmed Death Ligand 1 (PD-L1)
- Basal Markers (CK5/6, EGFR)
- Androgen Receptor (AR)
- E-Cadherin and P120
- Conclusion
- Selected References
- References
- 22. Fibroepithelial Tumors and Hamartomas
- Abstract
- Introduction
- Hamartoma
- Fibroadenoma
- Phyllodes Tumors
- Selected References
- References
- 23. Lymphomas of the Breast
- Abstract
- Definition and Epidemiology
- Clinical Features
- Imaging Studies
- Staging
- Treatment
- Histopathologic Spectrum of Primary Breast Lymphoma
- Selected References
- References
- 24. Mesenchymal Neoplasms of the Breast
- Abstract
- Vascular Tumors
- Fibroblastic and Myofibroblastic Neoplasms
- Neural Neoplasms
- Metastatic Tumors
- Conclusion
- Selected References
- References
- 25. Unusual and Rare Tumors of the Breast
- Abstract
- Introduction
- Rare Tumors Without Salivary Gland Analogs
- Rare Tumors with Salivary Gland Analogs
- Conclusion
- Selected References
- References
- Section VII: Prognostic Factors for Breast Cancer
- 26. Clinical Prognosis and Staging of Breast Cancer
- Abstract
- Introduction
- Anatomic Stage Groups
- AJCC Prognostic Stage Groups
- Molecular Testing and Clinical Prognosis
- Age and Race
- Obesity
- Socioeconomic Disadvantage
- Pregnancy
- Gender
- Histologic Type, Grade, and Proliferation Markers
- Type of Metastases
- Circulating Tumor Cells
- Selected References
- References
- 27. Molecular Biomarkers for Breast Cancer Prognosis
- Abstract
- Introduction
- Conventional (Tissue-Based) Molecular Prognostic Biomarkers
- Investigational (Liquid Biopsy–Based) Prognostic Biomarkers
- Summary
- Acknowledgment
- Selected References
- References
- 28. Examining Domestic and International Disparities in Breast Cancer Screening, Treatment, and Outcomes
- Abstract
- Introduction
- Disparities Along the Continuum of Cancer Care
- Systemic Contributors to Disparities in Breast Cancer
- Conclusion
- Selected References
- References
- Section VIII: Surgical Techniques of the Breast
- 29. Management of Lobular Neoplasia and Ductal Carcinoma in Situ
- Abstract
- Lobular Neoplasia
- Historical Background
- Lobular Carcinoma in Situ Histopathology
- Clinical Presentation, Natural History, and Biologic Significance of Lcis
- Endocrine Chemoprevention for Lobular Carcinoma in Situ
- Surgical Intervention for Lobular Carcinoma in Situ
- Conclusions
- Ductal Carcinoma in Situ
- Pathology
- Detection and Diagnosis
- Prospective Randomized Ductal Carcinoma in Situ Trials
- Tamoxifen for Ductal Carcinoma in Situ
- Determination of HER2/Neu Status and Potential Benefit of Neoadjuvant Trastuzumab
- Treatment Selection for Patients With Dcis
- Oncotype Dx Breast Dcis Score
- DCISionRT
- Sentinel Node Biopsy for Ductal Carcinoma in Situ
- Summary
- Acknowledgments
- Selected References
- References
- 30. General Principles of Mastectomy: From Halsted Radical Mastectomy and Modified Radical Mastectomy to Total (Simple) Mastectomy
- Abstract
- Development of the Radical Mastectomy—Historical Aspects
- Modified Radical Mastectomy
- Total (Simple) Mastectomy
- Breast Cancer Treatment in the United States
- Contralateral Prophylactic Mastectomy in Patients with Breast Cancer
- Prophylactic Mastectomy in High-Risk Patients
- Indications for Radical or Modified Radical Mastectomy
- Mastectomy Technique
- Selected References
- References
- 31. Breast Conservation Therapy for Invasive Breast Cancer
- Abstract
- Historical Perspective
- Breast Conservation Therapy Goals
- Patient Selection
- Magnetic Resonance Imaging
- Operative Technique
- Axilla
- Radiation Therapy
- Selected References
- References
- 32. Intraoperative Evaluation of Surgical Margins in Breast-Conserving Therapy
- Abstract
- Importance of Margins in Breast-Conserving Surgery
- Margin Positivity Incidence and Dilemma
- Planning Breast Conservation Surgery
- Specimen Orientation
- Specimen Inking
- Gross Inspection of Tumor Margins
- Cytologic Touch Preparation
- Frozen Section Analysis
- Intraoperative Ultrasound
- Intraoperative Specimen Radiography
- Cavity Shave Margin Technique
- Future Directions
- Summary and Conclusions
- Selected References
- References
- 33. Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer
- Abstract
- History of Sentinel Node Concept in Breast Cancer
- Evolution of Dye-Directed Sentinel Lymphadenectomy for Breast Cancer
- Complete Nonsentinel Node Staging and Proof of Principle
- Prospective Study of Sentinel Lymphadenectomy alone for a Tumor-Free Sentinel Node
- Identification of the Sentinel Node in Breast Cancer by Radiolocalization
- Identification of the Sentinel Node with Preoperative Lymphoscintigraphy and Intraoperative Radioguided Surgery
- Combined Technique of Vital Dye and Radioisotope
- Global Experience With Sentinel Lymphadenectomy in Breast Cancer
- Multicenter Lymphatic Mapping Trials
- Clinical, Pathologic, and Technical Aspects of Sentinel Lymphadenectomy
- Technical Considerations
- Radiolocalization and Lymphatic Mapping With Isotopes
- Histopathologic Evaluation
- Morbidity of Sentinel Lymphadenectomy
- Learning Curve
- Prospective Randomized Clinical Trials
- Summary
- Selected References
- References
- 34. Lymphatic Mapping and Targeted Axillary Dissection Procedure After Neoadjuvant Chemotherapy
- Abstract
- Introduction
- Evolution of Axillary Management
- Clinically Node-Negative Patients Receiving Neoadjuvant Chemotherapy
- Clinically Node-Positive Patients Receiving Neoadjuvant Chemotherapy
- Future Directions
- Conclusion
- References
- Selected References
- 35. Therapeutic Value of Axillary Node Dissection
- Abstract
- Lymphatic Function and Nodal Metastases
- Axillary Anatomy and Evaluation
- Axillary Radiotherapy
- Therapeutic Role of Axillary Node Dissection
- Selective Management of Axilla
- Targeted Axillary Lymph Node Dissection
- Selected References
- References
- 36. Lymphedema Prevention and Treatment: Axillary Reverse Mapping, LYMPHA, Lymph Node Transfer, and Other Surgical Techniques
- Abstract
- Introduction
- Surgical Prevention of Lymphedema
- Surgical Treatment of Lymphedema
- Conclusion/Summary
- Selected References
- References
- 37. Wound Care and Complications of Mastectomy
- Abstract
- Care of the Postmastectomy Wound
- Complications of Mastectomy
- Selected References
- References
- 38. Pain Management of the Breast Cancer Surgery Patient
- Prehospital Setting
- Intraoperative Management
- Regional Analgesia
- Postoperative/Postdischarge Management
- Conclusion
- Selected References
- References
- Section IX: Oncoplastic Breast Surgery and Reconstruction
- 39. Optimizing Cosmetic Outcomes for Breast Surgery
- Abstract
- General Considerations
- Preoperative Planning
- Summary
- Selected References
- References
- 40. Upper Hemisphere Oncoplastic Surgery
- Abstract
- Introduction
- The Tailored Upper Hemisphere Ops Procedure
- Conclusion
- Suggested References
- References
- 41. Oncoplastic Techniques for the Lower Hemisphere of the Breast
- Abstract
- Introduction
- Preoperative Evaluation
- Surgical Technique
- Postoperative Management
- Complications
- Conclusion
- Selected References
- References
- 42. Oncoplastic Breast Reconstruction: Extreme Oncoplasty and Split Reduction Techniques
- Abstract
- Introduction
- Indications
- Preoperative Evaluation and Planning
- Surgical Technique
- Surgical Complications and Solutions
- Results
- Conclusions
- Selected References
- References
- 43. Nipple Skin-Sparing Mastectomy
- Abstract
- Introduction
- Indications
- Surgical Technique
- Registries
- Complications
- Oncological Outcome
- Patient-Reported Outcomes
- Endoscopic and Robotic Nsm
- Selected References
- References
- 44. Breast Reconstruction
- Abstract
- Role of Reconstruction in Breast Cancer Treatment
- Definition of the Mastectomy Deformity
- Reconstructive Surgical Methods
- Conclusions
- Selected References
- References
- Section X: Adjuvant Therapy for Stages 0, I, and II Breast Cancer
- 45. Radiotherapy and Regional Nodes
- Abstract
- Introduction
- Principles of Regional Nodal Management
- Techniques for Regional Nodal Irradiation
- Conclusions
- Selected References
- References
- 46. Postmastectomy Radiation Therapy
- Abstract
- Historical Perspective on Postmastectomy Radiation Therapy
- Postmastectomy Radiation Therapy in the Era of Modern Systemic Therapy: A Potential Systemic Effect of Pmrt
- The Role of Postmastectomy Radiation Therapy After Neoadjuvant Chemotherapy
- Ongoing Controversies in Postmastectomy Radiation Therapy
- Current Treatment Techniques for Postmastectomy Radiation Therapy
- Conclusions
- Selected References
- References
- 47. Breast-Conserving Therapy for Invasive Breast Cancers
- Abstract
- Introduction
- Breast-Conserving Surgery and Radiation Therapy as an Alternative to Mastectomy
- Patient Selection for Breast-Conserving Surgery and Whole Breast Radiation
- Hypofractionated Whole-Breast Irradiation
- Tumor Bed Radiation Boost
- Technical Advances in Whole Breast Irradiation
- Timing of Whole-Breast Radiation Therapy in Relation to Surgery and Systemic Therapies
- Management of Local Failure After Breast-Conserving Surgery and Radiation Therapy
- Breast-Conserving Surgery without Radiation Therapy
- Conclusions
- Selected References
- References
- 48. Partial Breast Irradiation: Accelerated and Intraoperative
- Abstract
- Background and Rationale
- Accelerated Partial Breast Irradiation
- Intraoperative Radiation Therapy
- Expert Consensus Statements
- Future Directions
- Selected References
- References
- 49. Radiation Complications and Their Management
- Abstract
- Introduction
- Fatigue and Myelosuppression
- Radiation Dermatitis and Infections
- Cosmesis and Breast-Related Symptoms
- Rib Fracture
- Brachial Plexopathy
- Pulmonary Complications
- Cardiac Complications of Breast-Conserving Treatment
- Second Malignancies
- Complications in Patients with Collagen Vascular Disease
- Conclusions
- Selected References
- References
- 50. Radiation Therapy for Locally Advanced Breast Cancer: Historical Review to Current Approaches
- Abstract
- Introduction
- Epidemiology and General Management
- Evolution of Treatment for Labc: A History
- Rationale for Adjuvant Radiotherapy in Labc
- Radiotherapy in the Era of Neoadjuvant Chemotherapy
- Inflammatory Breast Cancer
- Radiotherapy Treatment Planning and Delivery
- Conclusion
- Selected References
- References
- 51. Systemic Therapy of Hormone-Sensitive HER2-Negative Breast Cancer: Adjuvant and Neoadjuvant
- Abstract
- Introduction
- Overview of Types of Systemic Therapy for Er/Pr-Positive, Her2-Negative Early Breast Cancer
- Adjuvant Systemic Therapy for Er/Pr-Positive Ductal Carcinoma in Situ
- Adjuvant Endocrine Therapy for Er/Pr-Positive, Her2-Negative Early-Stage Invasive Breast Cancer
- Adjuvant Chemotherapy for Er/Pr-Positive, Her2-Negative Early-Stage Invasive Breast Cancer
- Incorporating Targeted Therapies into Adjuvant Treatment for Er/Pr-Positive, Her2-Negative Early-Stage Invasive Breast Cancer
- Factors to Consider in Selecting Systemic Therapy for Early-Stage Invasive Er/Pr-Positive Her2-Negative Breast Cancer
- Common Side Effects of Adjuvant Endocrine Therapy
- Conclusions and Future Directions
- Selected References
- References
- 52. Adjuvant and Neoadjuvant Systemic Therapies for Triple-Negative Breast Cancer
- Abstract
- Introduction
- Chemotherapy
- Immunotherapy
- Germline Brca1 and 2 Mutation Carriers
- Future Directions
- Conclusions
- Selected References
- References
- 53. Adjuvant and Neoadjuvant HER2 Therapy
- Abstract
- Introduction
- Neoadjuvant Therapy
- Adjuvant Therapy
- Conclusions
- Conflicts of Interest
- Selected References
- References
- Section XI: Management of Advanced Local, Regional, and Systemic Disease
- 54. Surgical Procedures for Advanced Local and Regional Malignancies of the Breast
- Non-Print ItemAbstract
- Introduction
- Treatment Approaches for Locally Advanced Breast Cancer
- Summary
- Selected References
- References
- 55. Management of the Intact Breast Primary in the Setting of Metastatic Disease
- Abstract
- Introduction
- Retrospective Analyses of Primary Site Local Therapy in De Novo Metastatic Breast Cancer
- Randomized Prospective Trials
- Trials Evaluating Primary Site Local Therapy Following Response to Systemic Induction Therapy
- Trials Evaluating Primary Site Local Therapy for De Novo Metastatic Breast Cancer Without Systemic Induction Therapy
- Prospective Registry Trials Evaluating Pslt in De Novo Mbc
- Who Should Be Offered Primary Site Locoregional Therapy?
- Conclusion
- Selected References
- References
- 56. Locoregional Recurrence of Breast Cancer
- Abstract
- Definitions
- Incidence
- Detection and Diagnosis
- Local Treatment of Lrr
- Systemic Therapy for Lrr
- Survival After Lrr
- Conclusion
- Selected References
- References
- 57. Locally Advanced and Inflammatory Breast Cancer
- Abstract
- Noninflammatory LABC
- IBC
- Conclusions
- Selected References
- References
- 58. Clinical Implications of Occult Systemic Micrometastatic Breast Cancer
- Abstract
- Introduction
- Liquid Biopsy
- Detection of Ctdna
- Prognostication in Early-Stage Breast Cancer
- Detection of Minimal Residual Disease in Early-Stage Breast Cancer
- Screening for Breast Cancer in Asymptomatic Individuals
- Conclusions and Future Directions
- Selected References
- References
- 59. Management of Breast Cancer Solitary Metastases
- Abstract
- Liver
- Lung
- Bone
- Brain
- Summary
- References
- Selected References
- 60. Management of Bone Metastases in Breast Cancer
- Abstract
- Introduction
- Pathophysiology
- Clinical Presentation
- Diagnosis
- Treatment
- Surgical Management
- Radiotherapy
- Systemic Osteoclast Inhibitors
- New Treatment Modalities
- Conclusions and Recommendations
- Acknowledgment
- Selected References
- References
- 61. Chemotherapy and HER2-Directed Therapy for Metastatic Breast Cancer
- Abstract
- Introduction
- Epidemiology
- Therapeutic Goals
- Prognostication
- Medical Evaluation in the Metastatic Setting
- Local Therapy for Metastatic Breast Cancer
- Selecting Therapy for Metastatic Breast Cancer
- Chemotherapy for Metastatic Breast Cancer
- Special Considerations
- Monitoring Response to Therapy
- Future of Systemic Therapy for Metastatic Breast Cancer
- Selected References
- References
- 62. Endocrine Therapy for Late-Stage and Metastatic Breast Cancer
- Abstract
- History of Endocrine Therapy in Breast Cancer
- General Strategies for Targeting the Hormonal Axis
- Key Therapeutic Antiestrogen Agents
- Management of Advanced or Metastatic HR+HER2-Negative Breast Cancer in Postmenopausal Women
- Management of HR+HER2-Negative Advanced or Metastatic Breast Cancer in Premenopausal Women
- Future Directions in the Management of HR+HER2-Negative Metastatic Breast Cancer
- Conclusion
- Selected References
- References
- 63. Immunological Approaches to Breast Cancer Therapy
- Abstract
- Principles of Breast Cancer Immunotherapy
- Advanced Breast Cancer
- Early Breast Cancer
- Innovative Immunotherapy Approaches
- Antigen-Directed Immunotherapy
- Conclusion
- Selected References
- References
- 64. Diagnosis and Management of Pleural Metastases and Malignant Effusion in Breast Cancer
- Abstract
- Pathogenesis
- Clinical Presentation
- Diagnosis
- Treatment: Indications, Approaches, and Complications
- Prognosis
- Summary
- Selected References
- References
- 65. Management of Central Nervous System Metastases in Breast Cancer
- Abstract
- Incidence and Risk Factors
- Methods of Spread and Distribution
- Clinical Presentation
- Diagnostic Evaluation
- Prognosis
- Principles of Multidisciplinary Management in Patients with Cns Metastases
- Management of Brain Metastases
- Management of Leptomeningeal Disease
- Management of Epidural Spinal Cord Compression
- Supportive Care Measures
- Summary and Conclusions
- Selected References
- References
- Section XII: Special Presentations of Breast Cancer
- 66. Bilateral Breast Cancer
- Abstract
- Risk Factors for Bilateral Breast Cancer
- Impact of Advanced Imaging and Adjuvant Therapy on Bilaterality
- Prognosis of Bilateral Breast Cancer
- Contralateral Prophylactic Mastectomy
- Recommendations and Future Directions
- Selected References
- References
- 67. Male Breast Cancer
- Abstract
- Epidemiology
- Race and Ethnicity
- Risk Factors
- Clinical Features
- Diagnosis
- Pathology
- Treatment
- Metastatic Disease
- Prognosis
- Survivorship Issues and Surveillance
- Management Summary
- Selected References
- References
- 68. Local Recurrence, the Augmented Breast, and the Contralateral Breast
- Non-Print Item Abstract
- Introduction
- Future Breast Cancer Risk
- Locoregional Recurrence
- Reconstructive Considerations in Patients Undergoing Treatment for Locoregional Recurrence Following Breast Conservation and Mastectomy
- Reconstruction in Patients Following Salvage Mastectomy for in-Breast Recurrence
- Chest Wall Reconstruction Following Chest Wall Resection for Local Recurrence Following Mastectomy
- Breast Cancer in the Augmented Breast
- Selected References
- References
- 69. Carcinoma of the Breast in Pregnancy and Lactation
- Abstract
- Epidemiology
- Pathologic Findings
- Presentation, Diagnostic Evaluation, and Staging During Pregnancy
- Imaging Studies During Pregnancy
- Breast Biopsy During Pregnancy
- Treatment
- Surgery
- Systemic Treatments
- Radiation Therapy
- Maternal Prognosis
- Obstetric AND Postdelivery Care
- Special Issues
- Impact oF Treatment on Fertility AND Fertility Counseling
- Conclusion
- Selected References
- References
- 70. Unknown Primary Presenting With Axillary Lymphadenopathy
- Abstract
- Incidence
- Diagnosis
- Management
- Selected References
- References
- Section XIII: Survivorship, Follow-Up Care, and Rehabilitation of the Breast Cancer Patient
- 71. Creating a Breast Cancer Survivorship Plan and Clinic
- Abstract
- Background
- Survivorship Guidelines and Mandates
- Unmet Needs, Gaps, and Barriers in Survivorship Care
- Survivorship Care Models
- Survivorship Clinic Nuts and Bolts
- Putting it Together
- Future Research Opportunities
- Conclusion
- Selected References
- References
- 72. General Considerations for Follow-Up
- Abstract
- Surveillance for Locoregional Recurrences or New Primary Disease
- Detecting Distant Relapse
- Long-Term and Late Effects of Cancer Treatment
- Selected References
- References
- 73. Bone-Modifying Agents in Early Breast Cancer
- Abstract
- Introduction
- Bisphosphonates—Mechanism of Action
- Types of Bisphosphonates
- Rationale for an Anticancer Effect for Bisphosphonates
- Denosumab—Mechanism of Action
- Clinical Trials on Adjuvant Bisphosphonates in Breast Cancer
- Individual Patient-Level Data Meta-Analysis
- New Data Since the Meta-Analysis
- Rationale for Bisphosphonate Benefit in Postmenopausal Women
- Safety of Adjuvant Bisphosphonates
- When to Consider Adjuvant Bisphosphonates
- Conclusions
- Selected References
- References
- 74. Fertility Preservation for Women With Breast Cancer
- Abstract
- Introduction
- Ovarian Biology and Gonadotoxicity
- Gonadotoxicity of Chemotherapy
- Fertility Preservation Options
- Experimental Approaches and Emerging Data
- Contraception and Cancer Therapy
- Pregnancy in Cancer Patients and Survivors
- Safety of Fertility Preservation
- Fertility Preservation in Clinical Practice
- Selected References
- References
- 75. Quality Measures and Performance Improvement for Breast Cancer Surgery
- Abstract
- Why measure quality?
- Who are the stakeholders for quality measurement?
- What is the us history of surgical quality measurement?
- What are quality and value?
- What are safety in surgery and diagnostic errors?
- How do we identify a gap in the quality of care?
- Where are the databases for quality and clinical outcomes research?
- How do we measure quality?
- What is a quality measure, and where do we find them?
- What are the quality reporting systems in the public sector?
- What is the future of public quality measurement reporting?
- How do we create the best quality measures?
- How do we rank a list of many quality measures?
- How are quality measures used?
- How do we analyze quality data and provide fair peer comparisons?
- What is a benchmark?
- How do we improve quality?
- Do quality measurement and improvement programs work?
- Have the breast-specific quality measurement programs improved breast care?
- What are the risks of quality measurement?
- What are the future challenges in quality measurement?
- Conclusion
- Selected References
- References
- 76. Lymphedema in the Postsurgical Patient: Pathophysiology and Nonoperative Management
- Abstract
- History
- Anatomy
- Pathophysiology
- Etiologic Risk Factors and Incidence
- Lymphedema from Radiation Treatment
- Classification
- Patient History and Measurement of Lymphedema
- Nonoperative Management of Lymphedema
- Summary
- Selected References
- References
- 77. Management of Menopause in Breast Cancer Survivors
- Abstract
- What is the Experience of Menopause in Women With Breast Cancer?
- Vasomotor Symptoms
- Management of Genitourinary Symptoms of Menopause
- Depression
- Osteoporosis
- Cardiovascular Health
- Conclusions
- Selected References
- References
- 78. Rehabilitation
- Abstract
- Deconditioning
- Fatigue
- Exercise
- Upper Quadrant Dysfunction
- Prehabilitation
- Neuropathy
- Pain
- Cognitive Dysfunction
- Vocational Rehabilitation
- Conclusion
- Acknowledgment
- Selected References
- References
- 79. Psychosocial Consequences and Lifestyle Interventions
- Abstract
- Psychosocial Aspects of Breast Cancer
- Distress in Breast Cancer
- Lifestyle and Breast Cancer
- Conclusion
- Acknowledgments
- Selected References
- References
- Online Appendix
- Historical Trials
- Neoadjuvant Chemotherapy
- Neoadjuvant Endocrine Therapy
- Reconstruction Techniques
- Index
- Confidence is ClinicalKey
- No. of pages: 944
- Language: English
- Edition: 6
- Published: March 18, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780323833653
- eBook ISBN: 9780443286223
- eBook ISBN: 9780323833660
KB
Kirby I. Bland
Affiliations and expertise
Professor and Chairman, Department of Surgery; Deputy Director, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AlabamaEC
Edward M. Copeland
Affiliations and expertise
Emeritus Distinguished Professor, Chairman, Department of Surgery; Director of the Shands Cancer Center, Department of Surgery, University of Florida College of Medicine, Gainsville, FloridaVK
V. Suzanne Klimberg
Affiliations and expertise
The Courtney M. Townsend, Jr., M.D. Distinguished Chair in General Surgery, Vice Chair for Administration, Professor of Surgery, University of Texas Medical Branch, Galveston, TexasWG
William J Gradishar
Affiliations and expertise
Betsy Bramsen Professor of Breast Oncology, Professor, Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois