Biosensors in Precision Medicine
From Fundamentals to Future Trends
- 1st Edition - February 13, 2024
- Imprint: Elsevier
- Editors: Laís Canniatti Brazaca, Juliane Renata Sempionatto
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 3 8 0 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 3 8 1 - 5
Biosensors in Precision Medicine: From Fundamentals to Future Trends covers important topics regarding biomarkers, including biomarker discovery, validation, application in precis… Read more
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Request a sales quoteBiosensors in Precision Medicine: From Fundamentals to Future Trends covers important topics regarding biomarkers, including biomarker discovery, validation, application in precision medicine, the principles of biosensors, their use in precision medicine, important analytical parameters, recent advances in bioreceptors and transduction, and more. Finally, the hottest trends of biosensors in precision medicine, including lab-on-a-chip and wearable devices, advances towards telemedicine, machine learning, artificial intelligence and the commerciality of these devices are discussed.
- Provides a timely review of the state-of-the-art developments in biosensors and their applications in precision medicine
- Presents an evaluation of case studies, along with real-life examples
- Addresses recent trends on biosensors for precision medicine
Graduate students, Professors and Postdoctoral Researchers within Analytical Chemistry, Medical researchers that work in precision medicine may also be interested in the proposed book, graduate students, professors and postdoctoral researchers
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Part 1: Biomarkers and precision medicine
- Chapter 1. Biomarkers: an introduction
- Abstract
- 1.1 Introduction
- 1.2 Biomarker’s discovery journey
- 1.3 Old and new biomarkers—an overview
- 1.4 Biomarker industry
- References
- Chapter 2. Biomarkers in precision medicine
- Abstract
- 2.1 Applications of biomarkers in medicine
- 2.2 Pharmacogenomics and biomarkers
- 2.3 Postmarket drug surveillance and monitoring of adverse drug reactions
- 2.4 Exploring the frontier of digital biomarkers
- 2.5 Discovering biomarkers with microsampling technology
- 2.6 Future directions
- References
- Part 2: Biosensors and their applications in precisionmedicine
- Chapter 3. Biosensors: an introduction
- Abstract
- 3.1 Overview
- 3.2 Bioreceptors: immobilization and recognition events
- 3.3 Bioreceptors immobilization approaches
- 3.4 Transduction and detection techniques
- 3.5 Transduction and detection approaches
- 3.6 Targets in precision medicine
- 3.7 Conclusion
- References
- Chapter 4. Validation of biosensors
- Abstract
- 4.1 Introduction
- 4.2 Analytical validation
- 4.3 Validating a biosensor—assessment of its figure of merits
- 4.4 Validating with real-world samples
- 4.5 Sampling and validating biofluids assays
- 4.6 Current challenges and outlook
- References
- Chapter 5. The application of biosensors in precision medicine
- Abstract
- 5.1 Introduction
- 5.2 Precision medicine and its applications
- 5.3 Traditional analytical techniques for biomarker detection
- 5.4 Biosensors in clinical applications
- 5.5 Biosensors in precision medicine
- 5.6 Strategies for drug delivery systems
- 5.7 Transdermal drug delivery
- 5.8 Implantable drug delivery
- 5.9 Prospects and outlook
- References
- Chapter 6. Recent advancements in bioreceptors and materials for biosensors
- Abstract
- 6.1 Introduction
- 6.2 Architecture, types, and receptor selection of the biosensor
- 6.3 Bioreceptors for biosensors
- 6.4 Materials for biosensors
- 6.5 Nanocomposites and nanomaterials
- 6.6 Conducting polymers
- 6.7 Materials for analyte enrichment and immobilization matrices
- 6.8 Hydrogel matrices
- 6.9 Immobilization matrices
- 6.10 Conclusions
- References
- Chapter 7. Recent advancements in detection and amplification techniques
- Abstract
- 7.1 Introduction
- 7.2 Emerging detection techniques based on nucleic acid detection deployed for point-of-care-based platforms
- 7.3 New amplification techniques
- 7.4 Conclusion
- References
- Part 3: Trends of biosensors in precision medicine
- Chapter 8. Lab-on-a-chip devices
- Abstract
- 8.1 Introduction
- 8.2 Manufacturing technologies: material used in lab-on-chip
- 8.3 Advantages of lab-on-a-chip compared to traditional methods
- 8.4 Limitations of lab-on-a-chip compared versus traditional methods
- 8.5 Immobilization of biorecognition element in microfluidic channels
- 8.6 Microfluidics integrated point-of-care platforms
- 8.7 Current challenges and research
- 8.8 Conclusions and perspectives
- References
- Chapter 9. Wearable flexible biosensing devices contributing to modern precision medicine
- Abstract
- 9.1 Introduction
- 9.2 How wearables can support precision medicine
- 9.3 Flexible biosensors for on-body detection
- 9.4 Electrical energy for wearable flexible devices
- 9.5 Integration of microfluidics with flexible bioelectronics
- 9.6 Conclusion and prospects
- References
- Chapter 10. Improving quality of wearable biosensor data through artificial intelligence
- Abstract
- 10.1 Introduction
- 10.2 Wireless biosensor networks
- 10.3 Data errors in wireless biosensor networks
- 10.4 Artificial intelligence for biosensor data classification
- 10.5 Examples of applications of AI biosensors
- 10.6 Conclusions
- References
- Chapter 11. Commercial potential of biosensors
- Abstract
- 11.1 Introduction to biosensors development and commercialization in medical applications
- 11.2 Commercially available biosensors for medical diagnoses
- 11.3 Challenges and future trends
- Acknowledgments
- References
- Index
- Edition: 1
- Published: February 13, 2024
- Imprint: Elsevier
- No. of pages: 408
- Language: English
- Paperback ISBN: 9780443153808
- eBook ISBN: 9780443153815
LB
Laís Canniatti Brazaca
Laís Canniatti Brazaca received her M.S. and Ph.D. degrees from São Carlos Institute of Physics, University of São Paulo (IFSC/USP), Brazil, in 2015 and 2019, respectively. She is currently an associated professor at São Carlos Institute of Chemistry, University of São Paulo (IQSC/USP). Laís has been working in the development of electrochemical and colorimetric biosensors for aiding in medical diagnosis for the last 12 years, having experience with antibody-, DNA-, enzyme- and aptamer-based devices. Her specialties include microfabrication, electrodes modification, nanomaterials for sensing applications and wearable and paper-based devices.
Affiliations and expertise
Associated Professor, São Carlos Institute of Chemistry, University of São Paulo (IQSC/USP), BrazilJS
Juliane Renata Sempionatto
Dr. Juliane R. Sempionatto has expertise in developing wearable electrochemical sensors to monitor medical relevant biomarkers in sweat, saliva, tears, and interstitial fluid. Her research interests include soft and stretchable electronics, high-performance electrochemical biosensors, and biofuel cells. Dr. Sempionatto is currently a postdoctoral researcher at Caltech in Prof Wei Gao’s group. She received her Ph.D. in Nanoengineering at UCSD, working with Prof Joseph Wang. Dr. Sempionatto has published over 32 peer-reviewed papers in renowned international journals such as Nature Biomedical Engineering, Adv. Science, Biosensors and Bioelectronics, and ACS sensors and have five patents based on her research. She is the recipient of the prestigious Siebel Scholar award (class of 2021).
Affiliations and expertise
Postdoctoral Researcher, Medical Engineering Department, California Institute of Technology, USARead Biosensors in Precision Medicine on ScienceDirect