Biosensors for Medical Applications

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Woodhead Publishing Series in Biomaterials

Introduction to biosensors

Part I: Principles and transduction approaches

Chapter 1: Electrochemical biosensors for medical applications

Abstract:

1.1 Introduction to electrochemical sensors

1.2 Electrochemical biosensing applications

1.3 Label-free approaches to electrochemical sensors

1.4 Conclusion and future trends

Chapter 2: Piezoelectric biosensors for medical applications

Abstract:

2.1 Introduction

2.2 Piezoelectric immunosensors

2.3 Piezoelectric genosensors

2.4 Piezoelectric biosensors with bio-mimetic receptors

2.5 Conclusions and future trends

Chapter 3: Nano-sized biosensors for medical applications

Abstract:

3.1 Introduction

3.2 Sensing modalities

3.3 Nanomaterial properties

3.4 Biosensors on the nanoscale

3.5 Conclusions

Chapter 4: Impedance interrogated affinity biosensors for medical applications: novel targets and mechanistic studies

Abstract:

4.1 Small molecule binding

4.2 Supramolecular structures

4.3 Electrochemical biosensor for clinical diagnostics

4.4 Challenges of carbohydrate sensing

4.5 Bioreceptors for carbohydrate sensing

4.6 Enzymes that act on carbohydrates

4.7 Impedimetric glucose biosensors

4.8 Impedimetric bacterial and viral immunosensors

4.9 Impedance and pathogens

4.10 Bioreceptors used in impedimetric pathogenic biosensor construction

4.11 Detection of exposure to infection

4.12 Conclusion

Chapter 5: Practical applications and protocols for enzyme biosensors

Abstract:

5.1 Introduction

5.2 Methods and approaches for using biosensors

5.3 Protocols for enzyme biosensors

Method

5.4 Problems arising from the construction and use of biosensors

Part II: Applications of medical biosensors

Chapter 6: Biosensors for DNA and RNA detection and characterization

Abstract:

6.1 Introduction to nucleic acids and base pairing

6.2 Principles of DNA/RNA sensing

6.3 Electrochemical DNA sensing

6.4 Optical DNA sensing

6.5 Quartz crystal microbalance and surface acoustic wave sensors

6.6 Microcantilever oligonucleotide sensors

6.7 Conclusions

Chapter 7: Biosensors for disease biomarker detection

Abstract:

7.1 Introduction

7.2 Disease biomarkers

7.3 Established technologies for disease biomarker detection

7.4 Proteins at surfaces

7.5 Emerging technologies for disease biomarker detection

7.6 Future trends

7.7 Sources of further information and advice

Chapter 8: Affibodies as an alternative to antibodies in biosensors for cancer markers

Abstract:

8.1 Introduction: cancer

8.2 Breast cancer

8.3 Human epidermal growth factor receptor 2 (HER2)

8.4 The immunoassay

8.5 Biosensors

8.6 Problems with antibodies

8.7 Affibodies

Chapter 9: Biosensors for drug testing and discovery

Abstract:

9.1 Introduction

9.2 Types of biosensor

9.3 Conclusion

9.4 Acknowledgements

Chapter 10: Biosensors for non-invasive measurements

Abstract:

10.1 Introduction

10.2 Biosensors for the detection of alcohol and lactate

10.3 Detection using electrochemical and amperometric biosensors

10.4 Detection using optical biosensors

10.5 Conclusions

Chapter 11: Wearable biosensors for medical applications

Abstract:

11.1 Introduction

11.2 Background

11.3 Considerations and requirements for wearable sensors

11.4 Types of wearable sensors

11.5 Temperature sensors

11.6 Mechanical sensors

11.7 Electrical sensors

11.8 Biological and chemical sensing

11.9 Clinical applications

11.10 Future trends

11.11 Sources of further information and advice

Index