Bioresorbable Polymers and their Composites

Characterization and Fundamental Processing for Pharmaceutical and Medical Device Development

1st Edition - November 23, 2023
Editors: Deepak Verma, Manunya Okhawilai, Kheng-Lim Goh, Seeram Ramakrishna, Pooria Pasbakhsh, Mohit Sharma
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 9 1 5 - 9
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 9 1 6 - 6

Bioresorbable Polymers and their Composites: Characterization and Fundamental Processing for Pharmaceutical and Medical Device Development provides a holistic view of these uni… Read more

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Bioresorbable Polymers and their Composites: Characterization and Fundamental Processing for Pharmaceutical and Medical Device Development provides a holistic view of these unique materials and their usage in a range of biomedical applications. The book is evenly divided between fundamentals, processing methods and modeling approaches, and includes detailed coverage of a variety of applications, such as drug delivery, medical devices and wound healing. Key aspects including biocompatibility, biodegradability and toxicology are also thoroughly covered, enabling the reader to be fully informed when fabricating and utilizing their selected bioresorbable polymer.

This book is an interdisciplinary and important reference for researchers in the fields of materials science, biomedical engineering, pharmaceutical science and regenerative medicine, as well as R&D groups in the development of medical devices.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
About the editors
Preface
Section 1. Fundamentals, processing, and modelling
Chapter 1. Introduction to bioresorbable polymers: Types and biomedical applications
1.1. Introduction
1.2. Bioresorbable polymers and their classifications: An overview
1.3. Polymer degradation: An overview
1.4. Bioresorbable polymer resorption process
1.5. Bioresorbable polymers and their biomedical applications
1.6. Conclusion
Chapter 2. Bioresorbable polymers and their composites for biomedical applications
2.1. Introduction
2.2. Salient properties of bioresorbable materials for biomedical application
2.3. Performance of bioresorbable materials in medical interventions
2.4. Conclusion
Chapter 3. Processing techniques for bioresorbable-based composites for medical device applications
3.1. 2D structure
3.2. 3D structure
3.3. Micro-molding
3.4. Particulate structures
3.5. Conclusion and outlook
Chapter 4. PCL-based composites and their utilizations in the medical sector
4.1. Introduction to biopolymer composites
4.2. Development and synthesis of PCL
4.3. Advantages of PCL-based composites in the medical sector
4.4. Applications of PCL in different medical sectors
4.5. Challenges and future of PCL in the medical sector
4.6. Conclusion
Chapter 5. Processing of PLA/PLLA-based composites for medical device applications
5.1. Introduction
5.2. The chemical structure and synthesis of PLA/PLLA polymers
5.3. The physical and thermal characteristics of PLA/PLLA polymers
5.4. PLA/PLLA-based composites fabrication methods
5.5. Biocompatibility and biodegradability of PLA/PLLA composites
5.6. Applications of PLA/PLLA composites in the medical sector
5.7. Future perspectives
5.8. Conclusion
Chapter 6. PHA/PHB/PHBV-based composites: development and biomedical applications
6.1. Introduction
6.2. Polyhydroxyalkanoates (PHA)
6.3. Polyhydroxybutyrate (PHB)
6.4. Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)
6.5. Conclusion
Chapter 7. Synthesis and applications of bioresorbable polymers for tissue engineering scaffolds
7.1. Introduction
7.2. Synthesis of bioresorbable polymers
7.3. Applications of bioresorbable tissue scaffold
7.4. Future trends
7.5. Conclusion
Chapter 8. Gelation and fabrication of bioresorbable-based hydrogels for drug-release applications
8.1. Introduction
8.2. Cross-linking of hydrogels
8.3. Hydrogel fabrication
8.4. Conclusion
Chapter 9. Molecular modeling of polymers for efficient drug-carrier applications
9.1. Introduction
9.2. Methods for molecular simulation for designing polymers
9.3. Applications of the polymer-based smart nanocarriers
9.4. Conclusion
Chapter 10. Electrospinning technique: A potential method to develop bioresorbable-based medical devices
10.1. Introduction
10.2. Fundamentals of electrospinning
10.3. Application of electrospun nanofiber membranes in medical protective equipment
10.4. Conclusion
Chapter 11. Modeling of drug release from a bioresorbable polymer matrix system
11.1. Introduction
11.2. Biodegradable/bioresorbable polymers
11.3. Factors affecting drug release from polymers
11.4. Diffusion law
11.5. Fundamentals of drug-release kinetics
11.6. Need for and objectives of mathematical models
11.7. Release kinetic modeling
11.8. How to select the best-fitting model
11.9. Conclusion and future perspectives
List of abbreviations
Section 2. Biomedical applications
Chapter 12. Bioresorbable polymers: A prospective utilization as an implant
12.1. Introduction
12.2. Characteristics of bioabsorbable polymers as implants
12.3. Application of bioabsorbable polymers
12.4. Conclusion
Chapter 13. Polymeric (PLGA-based) nanocomposites for application in drug delivery: Current state of the art and forthcoming perspectives
13.1. Introduction
13.2. PLGA properties (Martin and Averous, 2001; Nijenhuis et al., 1996; Tsuji et al., 2000; Passerini and Craig, 2001)
13.3. PLGA nanocomposite carriers: fabrication techniques
13.4. Applications of PLGA nanocomposites
13.5. Conclusions and future prospects
Abbreviations
Chapter 14. Bioresorbable polymers: Challenges and opportunities for development and applications of medical devices
14.1. Introduction
14.2. Bioresorbable polymers for drug-delivery systems
14.3. Bioresorbable polymers for medical devices
14.4. Bioresorbable polymers for tissue engineering
14.5. Conclusions
Chapter 15. Bioresorbable polymers for wound healing
15.1. Introduction
15.2. Wound-healing process
15.3. Factors affecting wound healing
15.4. Properties of bioresorbable polymers
15.5. Bioresorbable polymers for wound healing
15.6. Nanocomposites for wound healing
15.7. Conclusion and future perspectives
Chapter 16. Bioresorbable polymers/HNT blend composite wound dressings
16.1. Introduction to bioresorbable polymers
16.2. Classifications of bioresorbable polymers
16.3. Halloysite nanotubes
16.4. Bioresorbable polymer-based HNT composites
16.5. Mechanical properties of HNT-reinforced polymer blends
16.6. Antibacterial activity of HNT–polymer blends
16.7. Drug-delivery capacity of HNT–polymer blends
16.8. Wound dressings based on HNT–polymer blends
16.9. Challenges and limitations of HNT–polymer blends
16.10. Future prospects of HNT–polymer blends in biomedical applications
16.11. Conclusion
Chapter 17. Biobehavioral structure, elastic, optical, and thermoluminescence properties of AlxCay-xNd01P70 bioglasses
17.1. Introduction
17.2. Methods and measurements
17.3. Results and discussion
17.4. Summary and conclusion
Chapter 18. A prospective utilization of biodegradable polymers for controlled drug-delivery applications
18.1. Introduction
18.2. Classification of biodegradable polymers for CDDS
18.3. Application of biodegradable polymers in drug delivery
18.4. Mechanism involved in controlled release through polymers
18.5. Release kinetic
18.6. Examples of commercially available biodegradable polymer base products
18.7. Conclusion
Chapter 19. Bioresorbable polymer-based sensors for medical applications
19.1. Introduction
19.2. The essential principles of biodegradable polymers and their pertinent physiochemical attributes for medical utilization
19.3. A comprehensive review of current biodegradable sensing devices, classified according to their healthcare functionalities such as cardiac surveillance, glycemic level monitoring, and ophthalmic pressure assessment
19.4. An overview of the fabrication techniques for bioresorbable polymer-based sensors
19.5. Physical sensors
19.6. Chemical sensors
19.7. Conclusion
Index

Deepak Verma

Deepak Verma is currently working as an Assistant Professor, in the Department of Mechanical Engineering, at Graphic Era Hill University, Dehradun, India. He received his M.Tech from the College of Technology, GBPUA&T Pantnagar, India. He has more than 7 years of experience in teaching, research, and working within industry. His research interests include: Hybrid Reinforced/Filled Polymer Composites, Advance Materials: Graphene and Nanoclay, Wood fiber Reinforced/Filled Polymer Composites, Modification and Treatment of Natural Fibres and Solid Wood Composites, and Polymer blends. He has published 2 books, 16 book chapters, and more than 10 International journal papers in reputed journals.

Affiliations and expertise

Assistant Professor, Department of Mechanical Engineering, Graphic Era Hill University, Dehradun, India

Manunya Okhawilai

Dr. Manunya Okhawilai is a researcher at Metallurgy and Materials Science Research Institute, Chulalongkorn University. Her interest lies in polymer blends and polymer composite. Her main research areas are ballistic armour made from pure polymer composite, bipolar plate for polymer electrolyte membrane fuel cell and solid-state polymer electrolyte for energy storage. She has published over 20 publications including conference papers. Moreover, she has published book chapters in “Advanced and Emerging Polybenzoxazine Science and Technology” published by Elsevier.

Affiliations and expertise

Researcher, Metallurgy and Materials Science Research Institute, Chulalongkorn University, Bangkok, Thailand

Kheng-Lim Goh

Prof Kheng-Lim Goh is the director of research at the Newcastle University of Singapore, and associate professor in mechanics of materials. He leads the Advanced Composite Research Group where the research is focused on the mechanics of composite materials, covering development (lightweight composite materials), damage studies and repair, sustainability (UN SDG, Net Zero), mechanical systems and structures underpinning composite materials, with applications from aerospace, to automotive, construction and biomedical industry. He has published 100+ research articles in several international journals, conference proceedings and book chapters. As a Global Engagement Fellow presently he is working with his colleagues at University of Pittsburg, USA, on materials and sustainability.

Affiliations and expertise

Director of Research and Associate Professor in Mechanics of Materials, Newcastle University of Singapore, Singapore

Seeram Ramakrishna

Seeram Ramakrishna is the Director of the Center for Nanofibres and Nanotechnology at the National University of Singapore (NUS), which is ranked among the top 20 universities in the world. He is regarded as the modern father of electrospinning. He is an elected Fellow of UK Royal Academy of Engineering (FREng); Singapore Academy of Engineering; Indian National Academy of Engineering; and ASEAN Academy of Engineering & Technology. He is an elected Fellow of the International Union of Societies of Biomaterials Science and Engineering (FBSE); Institution of Engineers Singapore; ISTE, India; Institution of Mechanical Engineers and Institute of Materials, Minerals & Mining, UK; and American Association of the Advancement of Science; ASM International; American Society for Mechanical Engineers; American Institute for Medical & Biological Engineering, USA. He is an editor of Elsevier journal Current Opinion in Biomedical Engineering.

Affiliations and expertise

Professor, Department of Mechanical Engineering, National University of Singapore, Singapore

Pooria Pasbakhsh

Prof. Pooria holds a bachelor's degree in Materials Science and Engineering with a focus on Ceramics, a master’s degree in Metallurgy and Materials Selection, and a Ph.D. in Polymer Composites. With over 17 years of research, academic, and industrial experience, he has worked on numerous industrial, government-funded, and research projects in various countries, including Australia, Malaysia, Italy, the UK, Denmark, Singapore, and Iran. His areas of expertise included polymers, fibers, coatings, minerals, nanomaterials, biomedical applications, fuel cells, building materials, and composites. Throughout his career, he has held positions as an Associate Professor at Monash University Malaysia, a postdoctoral researcher at the University of Adelaide, and a Technical Sales Specialist at Anton Paar Australia. Additionally, he has been recognized as one of the “World’s Top 2% Scientists” since 2020 for his research impact in the fields of “Materials,” “Polymers,” and “Chemistry,” according to data released by Stanford University and Elsevier.

Affiliations and expertise

Research Fellow, Faculty of Engineering and Information Technology The University of Melbourne

Mohit Sharma

Dr Sharma’s current assignments are focused on lead technology acquisition for advanced materials innovative. He has lead major research projects in liaison with key industries and high value ventures, which aims to create social impact and value capture. He is proficiently contributing to filing patents (US, Singapore), industrial know-hows, technology showcases and publishing peer reviewed research papers in the area of advanced composites materials, energy saving/heat regulating coatings and tribological materials. His current research interests are composites materials processing & analyses, Nano-structured fiber-polymer interphases, Carbon/glass/polymer/natural fibers reinforced nano-composites, Nano-ceramics/metal oxide based coatings for energy saving and UV shielding applications, Industrial coatings and paint additives, Aviation grease degradation and RUL, Solid lubricants, Tribological analysis of materials in harsh environments, advanced structural materials development for aerospace, marine offshore and biomedical arenas. Before joining A*STAR in 2013, Dr Sharma worked as a Guest Scientist at Leibniz Institute of Polymer Research (IPF) Dresden, Germany and Institute of Lightweight Structures and Polymer Technology (ILK) Technical University (TU) Dresden, Germany.

Affiliations and expertise

A*STAR (Agency for Science, Technology and Research), Singapore

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Physical Sciences & Engineering

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Bioresorbable Polymers and their Composites

Characterization and Fundamental Processing for Pharmaceutical and Medical Device Development

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Empowering Progress

Institutional subscription on ScienceDirect

Deepak Verma

Manunya Okhawilai

Kheng-Lim Goh

Seeram Ramakrishna

Pooria Pasbakhsh

Mohit Sharma