Biophysical Aspects of Cardiac Muscle

List of Contributors

Foreword

Preface

I. The A. F. Huxley Symposium Lecture

On Arguing from One Kind of Muscle to Another

II. Gating Processes in Excitable Membranes

Intramembranous Charge Movement and Control of Cellular Functions by Membrane Voltage

Electrical Properties of Amphibian Slow Muscle Fibers

Charge Movement in the Membrane of Striated Muscle

Local Anesthetic Action on Inactivation of the Na Channel in Nerve and Skeletal Muscle: Possible Mechanisms for Antiarrhythmic Agents

Models of Gating Current and Sodium Conductance Inactivation

III. Ionic Transport Mechanisms in Generation of Cardiac Action Potential Plateau

Inward Rectifier: Carriers Vs. Channels

Calcium Transport in Excitable Membranes

Voltage Dependence of Tetrodotoxin Action in Mammalian Cardiac Muscle

The Effect of Cesium Ions on 42K Efflux in Cardiac Purkinje Fibers

Potassium Currents in Ventricular Muscle

General Discussion on "The Inward Rectifier"

IV. Structure and Function of the Sarcotubular System

Introductory Remarks: Structural Basis of E-C Coupling

Three-Dimensional Structure of Muscle Fiber

Optical Indications of Excitation-Contraction Coupling in Striated Muscle

Fluorescence Signals from Skeletal Muscle Fibers

The Aequorin Signal During Activation of Muscle

V. E-C Coupling in Heart Muscle

The Effect of Extracellular Potassium on the Excitation Contraction Coupling in Frog Heart

A Ca-Transport System for Activation of Tension in Frog Ventricular Muscle

E-C Coupling Studies on Skinned Cardiac Fibers

Membrane Control of Cardiac Contractile Systems

VI. Mechanisms of Drug Action in Cardiac Muscle

Digitalis: Inotropic and Arrhythmogenic Effects on Membrane Currents in Cardiac Purkinje Fibers

Two Mechanisms for the Inotropic Action of Ouabain on Sheep Cardiac Purkinje Fiber Contractility

Glycoside Induced Stimulation of Membrane Na-K ATPase—Fact or Artifact?

Analysis of Catecholamine Action in Frog Atrial Fibers