Biomedical Applications of Inorganic Photochemistry

1st Edition, Volume 80 - November 23, 2022
Imprint: Academic Press
Editors: Peter C. Ford, Rudi van Eldik
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 1 7 1 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 1 7 2 - 8

Biomedical Applications of Inorganic Photochemistry, Volume 80 in the Advances in Inorganic Chemistry series, highlights new advances in the field, with this new volume presentin… Read more

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Biomedical Applications of Inorganic Photochemistry, Volume 80 in the Advances in Inorganic Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Photochemical bio-signaling with Ruthenium complexes, Adventures in the photo-uncaging of small molecule bioregulators, Challenges in medicinal inorganic chemistry and best practices to ensure rigor and reproducibility, Strategic Design of Photo-functional Transition Metal Complexes for Targeted Bioimaging and Therapy, Photoactive Manganese carbonyl Complexes with fac-{Mn(CO)3} Moiety: Design, Application, and Potential as Prodrugs in CO Therapy, Mitochondrial Targeting Metal Complexes, and more.

Other chapters cover Photoactive Organometallic Compounds with Antimicrobial Properties, Photoactivated platinum anticancer complexes, New ruthenium phthalocyanines liposomal-encapsulated in modulation of nitric oxide and singlet oxygen release: Selectivity cytotoxicity effect on cancerous cell lines, Inorganic Nanoparticles Engineered for Light-Triggered Unconventional Therapies, Mechanistic insight into phot-activation of small inorganic molecules from the biomedical application perspectives, Ruthenium Complexes for Photoactivated Dual Activity: Drug Delivery and Singlet Oxygen Generation, and Leveraging the Photophysical Properties of Rhenium(I) Tricarbonyl Complexes for Biomedical Applications.

Cover
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Leveraging the photophysical properties of rhenium(I) tricarbonyl complexes for biomedical applications
Abstract
1: Introduction
2: Properties and applications of Re(CO)3 complexes
3: Re(CO)3 complexes as photoluminescent imaging agents
4: Simple diimine Re(CO)3 complexes exhibit anticancer activity
5: Pyridylimine Re(CO)3 complexes
6: Isonitrile-containing Re(CO)3 complexes
7: Photoactivation of Re(CO)3 anticancer agents
8: Conclusions and future outlook
Acknowledgments
References
Chapter Two: Strategic design of photofunctional transition metal complexes for cancer diagnosis and therapy
Abstract
1: Introduction
2: Transition metal complexes for targeted cancer diagnosis and therapy
3: Activatable transition metal complexes for cancer diagnosis and therapy
4: Conclusions and future perspective
Acknowledgments
References
Chapter Three: Advances in the design of photoactivated platinum anticancer complexes
Abstract
1: Introduction
2: Discovery of photoactive Pt(IV) anticancer complexes
3: Mechanism of action
4: Axial derivatives of Pt(IV) complexes
5: Pt(IV) azide–acetylene derivatives via “click” reactions
6: Nanocarriers
Acknowledgments
References
Chapter Four: Adventures in the photo-uncaging of small molecule bioregulators
Abstract
1: Introduction
2: PhotoNORMs and PhotoCORMs
3: Enhancing photoreaction SMB release rates with antennas
4: Moving toward the phototherapeutic window
5: Biological targeting
6: Summary
Acknowledgments
References
Chapter Five: Light-triggered unconventional therapies with engineered inorganic nanoparticles
Abstract
1: Introduction
2: Unconventional phototherapy: Basic concepts
3: Nonmetallic inorganic NPs
4: Noble metal-based NPs
5: Concluding remarks and future perspectives
Acknowledgments
References
Chapter Six: Photoactive manganese carbonyl complexes with fac-{Mn(CO)3} moiety: Design, application, and potential as prodrugs in CO therapy
Abstract
1: Introduction
2: Chemical and photochemical properties of the fac-{Mn(CO)3} moiety
3: Moving photosensitivity to visible region of light; Smart design of photoCORMs
4: Water-soluble photoCORMs for chemotherapeutic applications
5: Trackable photoCORMs that allow visualization of the CO donor within cellular matrix
6: Turn-ON photoCORMs that confirm CO delivery at the target site
7: PhotoCORMs with various coligands that confer specific drug actions
8: CO-releasing materials and platform design
9: Conclusion and future perspectives
Acknowledgment
References
Chapter Seven: Mechanistic insight into photoactivation of small inorganic molecules from the biomedical applications perspectives
Abstract
1: Introduction
2: Reactive small inorganic molecules (RSIM)
3: RSIM photogeneration in biological systems - Pathways and mechanisms
4: Photoresponsive materials - Examples and development trends
5: Conclusions and future directions
Acknowledgments
References
Chapter Eight: Ruthenium complexes for photoactivated dual activity: Drug delivery and singlet oxygen generation
Abstract
1: Introduction
2: Photodynamic therapy
3: Photochemotherapy
4: Dual activity
5: Concluding remarks
Acknowledgment
References
Chapter Nine: Photochemical biosignaling with ruthenium complexes
Abstract
1: Introduction
2: Advantages of ruthenium caged compounds
3: Inorganic caged compounds and clinical applications
4: Value in diversity
5: The fifth ligand itch
6: Three-dimensional localization
7: Cis, trans and other structures
8: A brief gaze into the future
Acknowledgments
References
Chapter Ten: Ruthenium phthalocyanines in nitric oxide modulation and singlet oxygen release: Selectivity and cytotoxic effect on cancer cell lines
Abstract
1: Introduction
2: Spectroscopic characteristics
3: Molecular orbital calculations
4: Light irradiation process
5: In vitro studies
6: Conclusions and future perspectives
Acknowledgment
References
Chapter Eleven: Photoactive organometallic compounds as antimicrobial agents
Abstract
1: Introduction
2: Group 4 and 5 organometallic complexes
3: Group 6 organometallic complexes
4: Group 7 organometallic complexes
5: Group 8 organometallic complexes
6: Group 9 organometallic compounds
7: Group 10 and 11 organometallic complexes
8: Summary and future perspectives
Acknowledgment
References
Chapter Twelve: Mitochondria-targeting transition metal complexes
Abstract
1: Introduction
2: Iridium
3: Platinum
4: Rhenium
5: Gold
6: Copper
7: Ruthenium
8: Osmium
9: Vanadium
10: Palladium
11: Rhodium
12: Zinc
13: Silver
14: Concluding remarks and future perspectives
Acknowledgments
References
Index

Peter C. Ford

Peter C. Ford is at the Department of Chemistry and Biochemistry, University of California Santa Barbara, CA, USA.

Affiliations and expertise

Department of Chemistry and Biochemistry, University of California Santa Barbara, CA, USA

Rudi van Eldik

Rudi van Eldik was born in Amsterdam (The Netherlands) in 1945 and grew up in Johannesburg (South Africa). He received his chemistry education and DSc degree at the former Potchefstroom University (SA), followed by post-doctoral work at the State University of New York at Buffalo (USA) and the University of Frankfurt (Germany). After completing his Habilitation in Physical Chemistry at the University of Frankfurt in 1982, he was appointed as Professor of Inorganic Chemistry at the Private University of Witten/Herdecke in 1987. In 1994 he became Professor of Inorganic and Analytical Chemistry at the University of Erlangen-Nürnberg, from where he retired in 2010. At present he is Professor of Inorganic Chemistry at the Jagiellonian University in Krakow, Poland, and Visiting Professor of Inorganic Chemistry at the N. Copernicus University in Torun, Poland. His research interests cover the elucidation of inorganic and bioinorganic reaction mechanisms, with special emphasis on the application of high pressure thermodynamic and kinetic techniques. In recent years his research team also focused on the application of low-temperature rapid-scan techniques to identify and study reactive intermediates in catalytic cycles, and on mechanistic studies in ionic liquids. He is Editor of the series Advances in Inorganic Chemistry since 2003. He serves on the Editorial Boards of several chemistry journals. He is the author of over 880 research papers and review articles in international journals and supervised 80 PhD students. He has received honorary doctoral degrees from the former Potchefstroom University, SA (1997), Kragujevac University, Serbia (2006), Jagiellonian University, Krakow, Poland (2010), University of Pretoria, SA (2010), and Ivanovo State University of Chemistry and Technology, Russia (2012). He has developed a promotion activity for chemistry and related experimental sciences in the form of chemistry edutainment presentations during the period 1995-2010. In 2009 he was awarded the Federal Cross of Merit (‘Bundesverdienstkreuz’) by the Federal President of Germany, and the Inorganic Mechanisms Award by the Royal Society of Chemistry (London). His hobbies include music, hiking, jogging, cycling and motor-biking. He is the father of two and grandfather of four children.

Affiliations and expertise

University of Erlangen-Nurnberg, Germany; Professor of Inorganic Chemistry, Jagiellonian University in Krakow, Poland

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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