Biomaterials for Vasculogenesis and Angiogenesis

1st Edition - May 19, 2022
Editors: Saeid Kargozar, Masoud Mozafari
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 8 6 7 - 9
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 8 6 8 - 6

Biomaterials for Angiogenesis and Vasculogenesis covers the application of materials designed to encourage new blood vessel formation. Angiogenesis and vasculogenesis play an i… Read more

Biomaterials for Vasculogenesis and Angiogenesis

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Biomaterials for Angiogenesis and Vasculogenesis covers the application of materials designed to encourage new blood vessel formation. Angiogenesis and vasculogenesis play an important role in tissue engineering and regenerative medicine research by promoting vascular networks inside engineered tissues and thereby increasing tissue healing and regeneration. However, researchers are faced with the challenge of finding suitable materials for improving angiogenesis and vascular formation in assays. This book reviews a broad range of biomaterials for the promotion of blood vessel genesis, from polymers and bioactive glass, to nanomaterial scaffolds and 3D angiogenic constructs.

In addition, the book covers a variety of applications for biomaterials in tissue repair and regeneration, including cardiovascular regeneration, liver tissue engineering and much more. It will serve as a detailed reference for researchers in academia and industry, working in the fields of biomedical science and engineering, materials science, regenerative medicine and translational medicine.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Foreword for “Biomaterials for Vasculogenesis and Angiogenesis”
Preface for “Biomaterials for Vasculogenesis and Angiogenesis”
Chapter 1 Angiogenesis and vasculogenesis: Status in tissue engineering
1.1 Tissue engineering: From repair toward regeneration
1.2 Importance of vasculogenesis and angiogenesis in tissue engineering
1.3 Biomaterials for improved angiogenesis
1.4 Bioactive molecules and stem cells for promoted angiogenesis
1.5 Therapeutic angiogenesis: Concepts for clinical practices
References
Chapter 2 Molecular mediators of vasculogenesis and angiogenesis
2.1 Introduction
2.2 Overview of the vasculogenesis, angiogenesis, and arteriogenesis
2.3 The process of angiogenesis
2.4 Proangiogenic growth factors and cytokines
2.5 Inhibitors of angiogenesis
2.6 Maturation of angiogenesis
2.7 Conclusion
References
Chapter 3 The role of cells in vascular network formation and angiogenesis induction
3.1 Introduction
3.2 Human vascular system: An overview
3.3 Basic structure of vessels
3.4 Cellular crosstalk during vasculogenesis and angiogenesis
3.5 Immune cells and angiogenesis
3.6 Stem/progenitors cells for improved angiogenesis
3.7 Summary and concluding remarks
References
Chapter 4 The importance of extracellular matrix (ECM) in vasculogenesis and angiogenesis
4.1 Introduction
4.2 ECM-cell communication
4.3 ECM: A reservoir for growth factors and matricellular proteins
4.4 Effect of ECM components on angiogenesis
4.5 Proangiogenic components of ECM
4.6 Antiangiogenic components of the ECM
4.7 ECM remodeling and angiogenesis
Conclusion
References
Chapter 5 Role of growth factors and cytokines in therapeutic angiogenesis
5.1 Introduction
5.2 Proangiogenic GFs
5.3 Angiogenic cytokines
5.4 Other GFs and cytokines
5.5 Summary
References
Chapter 6 Interplay between angiogenesis and neurogenesis in nerve regeneration
6.1 Introduction
6.2 Nerve regeneration in nervous system
6.3 Tissue engineering strategies in nerve regeneration
6.4 Cells for nerve regeneration
6.5 Growth factors in nerve regeneration
6.6 Angiogenesis in injured nervous system
6.7 Conventional nerve grafts
6.8 Conclusion
References
Chapter 7 Detection assays for vasculogenesis and angiogenesis
7.1 Introduction
7.2 In vitro assays
7.3 Ex vivo assays
7.4 In vivo assays
Conclusions and future outlook
References
Chapter 8 The effects of medicinal herbs and phytochemicals on angiogenesis and models of wound healing
8.1 Introduction
8.2 Phytochemicals and herbs in medicine: A brief history
8.3 Medicinal herbs for modulating angiogenesis
8.4 Phytochemicals
Conclusions and future outlook
References
Chapter 9 Calcium phosphate bioceramics for improved angiogenesis
9.1 Introduction
9.2 CaPs bioceramics: An overview
9.3 Clinical significance of angiogenesis in bone regeneration
9.4 CaPs bioceramics for improved angiogenesis
9.5 CaPs bioceramics for delivery of proangiogenic bioactive molecules
9.6 Summary and future perspectives
References
Chapter 10 Angiogenesis induction by bioactive glasses and glass-ceramics
10.1 Introduction
10.2 The role of ionic dissolution products from bioactive glasses in angiogenesis
10.3 Bioactive glass particles
10.4 Bioactive glass scaffolds
10.5 Bioactive glass coatings
10.6 Bioactive glass fibers
10.7 Composite materials incorporating bioactive glasses
Conclusions
References
Chapter 11 Angiogenesis induction by natural and synthetic polymers
11.1 Introduction
11.2 Angiogenesis
11.3 Angiogenic natural and synthetic biomaterials
Conclusions
References
Chapter 12 Composites for angiogenesis induction
12.1 Introduction
12.2 Angiogenesis
12.3 Angiogenesis inducers
12.4 Role of biomaterials in promoting angiogenesis
12.5 Applications of composite biomaterials for angiogenesis induction
Conclusions
Acknowledgments
References
Chapter 13 Three-dimensional (3D) angiogenic constructs
13.1 Introduction
13.2 Micropatterning
13.3 Nanofabrication of vascular networks
13.4 Constructing vascular structures with sacrificial materials
References
Chapter 14 Engineered vascularized tissue organs
14.1 Introduction
14.2 Microvascular (MVS) and tissue engineered blood vessels (TEBV)
14.3 Tissue engineering approaches for vascularized tissue/organs formation
14.4 Cell-based engineering
14.5 Clinical translation
14.6 Challenges and opportunities
References
Chapter 15 Role of organic nanomaterials in angiogenesis
15.1 Introduction
15.2 Organic NMs
15.3 Organic nanomaterials play the role of a delivery vehicle
15.4 Advanced delivery systems
15.5 Mechanisms of action
15.6 Endothelial cell proliferation
15.7 Endothelial cell migration
15.8 Mural cell recruitment
15.9 Conclusions
References
Chapter 16 Inorganic nanomaterials for improved angiogenesis
16.1 Introduction
16.2 Inorganic nanomaterials for improved angiogenesis
16.3 Summary and future prospects
References
Chapter 17 Nanosized carriers for delivery of angiogenic materials
17.1 Introduction
17.2 Living and nonliving angiogenic materials
17.3 Nanovehicles for angiogenic delivery
17.4 Conclusions
References
Chapter 18 Electrospun nanofibers for angiogenesis strategies
18.1 Introduction
18.2 Electrospinning: An overview
18.3 Polymers for electrospinning
18.4 Electrospun nanofibers meet angiogenesis
18.5 Angiogenic nanofibers for applied tissue engineering
18.6 Conclusions
References
Chapter 19 Biomaterials for angiogenesis applications in an orthopedic context
19.1 Defining clinical problems
19.2 Critical-size bone-defects and nonunions
19.3 Limitations of traditional therapy strategies
19.4 Embryonic skeletal development and bone healing
19.5 Traditional strategies for Bone-Tissue-Engineering
19.6 Are there better strategies?
19.7 What are bioactive glasses?
19.8 Are there any side effects to bioactive glasses?
19.9 Ionic dissolution products from bioactive glasses
References
Chapter 20 Skin wound healing: The critical role of angiogenesis
20.1 Introduction
20.2 Skin tissue: Anatomical and histological features
20.3 Skin wounds and diseases
20.4 Current therapies for chronic wounds
20.5 Tissue-engineered skin substitutes
20.6 The critical role of angiogenesis in skin wound healing
20.7 Proangiogenic strategies for skin regeneration and wound healing
20.8 Conclusions
References
Chapter 21 Role of angiogenesis in bladder tissue engineering
21.1 Introduction
21.2 Tissue engineering of bladder
21.3 Angiogenesis strategies in the bladder tissue engineering
21.4 Detection methods of angiogenesis in bladder tissue engineering
21.5 Conclusions and perspective
References
Index

Saeid Kargozar

Saeid Kargozar is a Fellow of the University of Texas Southwestern Medical Center (UTSW), USA. He was previously a Senior Assistant Professor of Tissue Engineering in the Department of Anatomy and Cell Biology, at Mashhad University of Medical Sciences in Iran. He received his M.S. in Medical Biotechnology in 2012 and his Ph.D. in Tissue Engineering in 2016, both from Tehran University of Medical Sciences, Iran. His current research interests include biocompatible materials and tissue engineering with special focus on bioactive glasses and the decellularized extracellular matrix (ECM). He is an active member of the American Ceramic Society and has published more than 118 peer-reviewed publications. According to a recent scientometric study published in PLOS Biology in 2021, he is listed amongst the top 2% of cited scientists in the world.

Affiliations and expertise

UT Southwestern Medical Center

Masoud Mozafari

Dr. Masoud Mozafari is a Fellow at Lunenfeld Tanenbaum Research Institute, Mount Sinai Health Hospital, University of Toronto. He was previously Assistant Professor and Director of the Bioengineering Lab, at the Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Cellular and Molecular Research Center, and Department of Tissue Engineering and Regenerative Medicine of the Iran University of Medical Sciences (IUMS), Tehran, Iran. Dr. Mozafari’s research interests range across biomaterials, nanotechnology, and tissue engineering, and he is known for the development of strategies for the treatment of damaged tissues and organs, and controlling biological substances for targeted delivery into the human body. Dr. Mozafari has received several awards, including the Khwarizmi Award and the Julia Polak European Doctorate Award for outstanding translational research contributions to the field of biomaterials. He has also received the WIPO Medal for Inventors from The World Intellectual Property Organization (WIPO), in recognition of his contributions to economic and technological development. Dr. Mozafari is currently working on the editorial board of several journals.

Affiliations and expertise

Research Fellow, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Canada

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health