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Elsevier

Biology of T Cells - Part B

  • 1st Edition, Volume 342 - January 9, 2019
  • Latest edition
  • Editors: Lorenzo Galluzzi, Nils-Petter Rudqvist
  • Language: English

Biology of T Cells - Part B, Volume 342, the latest release in the International Review of Cell and Molecular Biology series, offers an overview of the major molecular and ce… Read more

Description

Biology of T Cells - Part B, Volume 342, the latest release in the International Review of Cell and Molecular Biology series, offers an overview of the major molecular and cellular aspects of T-cell biology and their links to human pathophysiology. Chapters in this release include Metabolism of T lymphocytes in health and disease, T lymphocytes and autoimmunity, Cancer immunosurveillance by T cells, T lymphocytes as targets in viral disorders, Molecular mechanisms underlying pharmacological immunosuppression, T lymphocyte-based immunotherapeutics, In silico methods to analyze T cell biology, and Engineering Platforms for T Cell Modulation.

Key features

  • Contains individual chapters that focus on one specific facet of the development, phenotype, function, study or pathophysiological relevance of T lymphocytes
  • Presents the latest release in the International Review of Cell and Molecular Biology series

Readership

Expert investigators who may wish to expand their knowledge of the biology of T cells, and to newcomers to this exciting and rapidly expanding area of research

Table of contents

Preface
Lorenzo Galluzzi and Nils-Petter Rudqvist

1. Metabolism of T lymphocytes in health and disease
Timo Gaber

2. T lymphocytes and autoimmunity
Uqba Khan

3. Cancer immunosurveillance by T cells
Arnold Han

4. T lymphocytes as targets in viral disorders
Anne Monette

5. Molecular mechanisms underlying pharmacological immunosuppression
Nicolas Pallet and Marie-Anne Loirot

6. T lymphocyte-based immunotherapeutics
Saman Maleki Vareki

7. In silico methods to analyze T cell biology
Sebastiano Battaglia

8. Engineering Platforms for T Cell Modulation
Jonathan Schneck

Product details

  • Edition: 1
  • Latest edition
  • Volume: 342
  • Published: January 9, 2019
  • Language: English

About the editors

LG

Lorenzo Galluzzi

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA

NR

Nils-Petter Rudqvist

Nils-Petter Rudqvist received his M.Sc. (Physics, 2009) and Ph.D. (Medical Science, 2015) from the University of Gothenburg, Sweden. He decided to pursue an academic career and continue with his postdoctoral training in US. He first joined the Center for Radiological Research at Columbia University in New York where he studied gene signatures of radiation exposure. He then moved to Weill Cornell Medicine to join the program in radiation and immunity under the mentorship of Dr. Demaria. His current research is focused on investigating which neoantigens are key targets of the radiation-induced anti-tumor T cell response in mice and in patients treated with radiotherapy and immune checkpoint blockade. He recently demonstrated in a mouse model that radiation therapy diversifies the TCR repertoire of tumor infiltrating lymphocytes, an effect crucial for its synergy with immune checkpoint blockade treatment. Nils-Petter has also defined unique patters of expansion of TCR clonotypes in patients who respond or not to treatment with radiotherapy and ipilimumab. He has published 20 articles in peer-reviewed scientific journals and 60+ scientific conference abstracts.
Affiliations and expertise
Postdoctoral Associate in Radiation Oncology, Weill Cornell Medicine, USA

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