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Elsevier

Biological Fluid–Mediated Transport Mechanisms for Targeted Drug Delivery in Next-Generation Cancer Immunotherapy

  • 1st Edition - February 1, 2027
  • Latest edition
  • Authors: Khemraj Deshmukh, Arun Kumar Singh, Gourav Singh, Jitendra Kumar
  • Language: English

Biological Fluid-Mediated Transport Mechanisms for Targeted Drug Delivery in Next-Generation Cancer Immunotherapy addresses the critical need for innovative therapeutic platfo… Read more

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Description

Biological Fluid-Mediated Transport Mechanisms for Targeted Drug Delivery in Next-Generation Cancer Immunotherapy addresses the critical need for innovative therapeutic platforms that improve efficacy and reduce toxicity in cancer treatment. The volume explores how natural biofluids and derived carriers, like exosomes and extracellular vesicles, can serve as highly biocompatible vehicles for delivering immunotherapeutics. It emphasizes their roles in overcoming barriers such as immune evasion, rapid clearance, and systemic side effects, while also leveraging biofluid signatures for real-time diagnostics through liquid biopsies. The book encompasses topics from the composition and biomolecular content of biofluids to the engineering strategies for functionalization, targeting, and controlled release, integrating cutting-edge nanotechnologies and microfluidics.

This reference book supports the advancement of next-generation precision cancer immunotherapies by providing insights into biofluid dynamics, bioresponsive carriers, and personalized approaches. It bridges basic science with translational potential, fostering innovation in nanomedicine, immunology, and biomedical engineering, and aims to accelerate the clinical impact of biofluid-inspired drug delivery systems.

Key features

  • Explores biofluid-based platforms to optimize cancer immunotherapy
  • Integrates interdisciplinary perspectives from nanotechnology, immunology, and engineering
  • Highlights diagnostic and therapeutic roles of biofluids and extracellular vesicles
  • Discusses engineering strategies for functionalizing biofluid carriers
  • Addresses regulatory, scalability, and translational challenges

Readership

Pharmaceutical scientists

Table of contents

1. Biofluids and Cancer Immunotherapy: Fundamentals and Clinical Relevance

2. Navigating the Lymphatic System: Targeting Antigen Presentation Pathways

3. Bloodstream Delivery Strategies for Sustained Immunomodulation

4. Mucosal Biofluid Routes: Oral, Pulmonary, and Intranasal Immunotherapy

5. Exosomes and Extracellular Vesicles as Natural Delivery Vehicles

6. Lipid Nanoparticles and mRNA Platforms in Cancer Vaccination

7. Hydrogels and Implantable Depots for Local Immune Modulation

8. Stimuli-Responsive Carriers Tuned to Biofluid Microenvironments

9. Combination Immunotherapy Delivery via Biofluid-Compatible Systems

10. Imaging and Pharmacokinetic Modeling in Biofluid-Mediated Delivery

11. Safety, Manufacturing, and Regulatory Considerations in Clinical Translation

12. Future Perspectives: Personalized and AI-Enabled Biofluid-Based Immunotherapy

Product details

  • Edition: 1
  • Latest edition
  • Published: February 1, 2027
  • Language: English

About the authors

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Khemraj Deshmukh

Dr. Khemraj Deshmukh is a dedicated researcher and academician in the field of Biomedical Engineering with over more than 8 years (6 years of teaching, 1.5 years of research, and 2.5 years of industry experience). He earned his Ph.D. from the National Institute of Technology, Raipur, with his doctoral research focusing on the numerical study and evaluation of poly-electrolyte complex scaffolds under cryogenic conditions. His expertise spans computational dynamics, biomaterials, cryogenic heat transfer, cell culture fluid dynamics, soft materials, 3D bioprinting, and automation and control. He has published extensively in reputed SCI and Scopus-indexed journals, contributing over 30 research papers, book chapters, and conference proceedings. Notable works include studies on scaffold degradation under

cryogenic environments, flow dynamics in microchannels, and nanotechnology-based drug delivery. His interdisciplinary research also extends to artificial intelligence applications in healthcare and biomedical signal processing. In addition, he has authored several book chapters with IOP Publishing and holds both utility and design patents, including innovations such as a programmable cryogenic chamber and advanced biomedical devices. Dr. Deshmukh has successfully supervised 9 M.Tech dissertations and is currently guiding a 1 Ph.D. scholar. He has led projects funded by national agencies (40 lakh), including the fabrication of a 3D printer–based rotatory bioreactor for vascular tissue engineering. His achievements include the design and validation of a functional 3D bioprinter and development of compact cryogenic storage systems. A member of professional bodies and an active participant in international conferences, he continues to make impactful contributions to biomedical engineering research and education.

Affiliations and expertise
Assistant Professor, Biomedical Department School of Technology Mody University of Science and Technology, Lakshmangarh, India

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Arun Kumar Singh

Arun Kumar Singh is an Assistant Professor in the Department of Pharmacy at University School of Pharmaceutical Sciences, Rayat Bahra University V.P.O. Sahauran, India. He completed his M.Pharm in Pharmaceutics from Galgotias University, Greater Noida. His research interests include nano-formulation, blockchain, IoT, machine learning, artificial intelligence, big data analytics, cancer biology, and neuroscience. He has contributed to academic books and book chapters and has published review articles in the areas of pharmaceutical sciences and healthcare technology. His work focuses on interdisciplinary approaches integrating pharmaceutical research with emerging digital and computational technologies.
Affiliations and expertise
Assistant Professor, University School of Pharmaceutical Sciences, Rayat Bahra University V.P.O. Sahauran, Tehsil Kharar, Distt. Mohali, Punjab, India

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Gourav Singh

Dr. Gourav Singh is an accomplished researcher in medicinal chemistry with a keen focus on neurodegenerative diseases, especially Alzheimer's disease (AD). He earned his PhD from the Indian Institute of Technology (IIT) BHU, working under the mentorship of Dr Gyan Prakash Modi. His doctoral research centered on the rational design, synthesis, and biological evaluation of small molecules aimed at therapeutic intervention. Dr. Singh has co-authored ten research articles in high-impact journals, including ACS Chemical Neuroscience, European Journal of Medicinal Chemistry, and Bioorganic & Medicinal Chemistry. With a strong interdisciplinary foundation spanning organic synthesis, computational drug design, and biological validation, Dr. Singh effectively bridges chemistry and neuropharmacology. His work significantly advances translational drug discovery efforts targeting neurodegenerative disorders.
Affiliations and expertise
Assistant Professor, School of Pharmacy, Mody University of Science and Technology, Lakshmangarh, India

JK

Jitendra Kumar

Dr. Jitendra Kumar (Ph.D., Biomedical Engineering) is currently serving as an Assistant Professor in the Department of Biomedical Engineering at B.V. Raju Institute of Technology, Narsapur (Hyderabad). He earned his doctoral degree in Biomedical Engineering from the National Institute of Technology Raipur, India, in 2024, with his thesis focused on the Design and Analysis of Bio-inspired Porous Based Hip Implant Component. He holds an M.Tech. in Instrumentation and Control Engineering from VIT Pune (2011), a B.E. in Biomedical Engineering from NIT Raipur (2007), and a PGDMM in Material Management from Annamalai University (2019). With more than eight years of academic and industry experience, including roles as Biomedical Engineer under the National Health Mission and Assistant Professor at CSVTU Bhilai and SSTC Bhilai, His research expertise in finite element analysis, orthopaedic implants, 3D printing, porous scaffold design, computational fluid dynamics, biomaterials, tissue engineering, and biomedical signal processing. His research contributions include several peer-reviewed journal publications, conference papers, and three patents filed/granted in the domain of biomedical implants and medical devices. He is proficient in advanced computational and experimental tools such as ANSYS (Structural & CFD), MATLAB, Materialise Mimics, 3D Printing, SEM, TEM, and Micro-FTIR. Dr. Kumar is a lifetime member of the Biomedical Engineering Society of India (LM-1535) and has actively participated in specialized training programs on organ printing, biomaterials, and advanced microscopy techniques. He has contributed significantly to the design and analysis of orthopedic and scaffold structures inspired by triply periodic minimal surfaces, balancing mechanical strength with additive manufacturability.
Affiliations and expertise
Assistant Professor, Department of Biomedical Engineering B.V. Raju Institute of Technology, Narsapur, Hyderabad, India