Biogenesis of Antibiotic Substances
- 1st Edition - January 1, 1965
- Imprint: Academic Press
- Editor: Zdenko Vanek
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 3 3 2 7 5 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 5 5 8 3 - 0
Biogenesis of Antibiotic Substances covers the proceedings of a panel discussion on ""Basic Research and Practical Aspects of Antibiotic Production"" held during the Antibiotic… Read more
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Request a sales quoteBiogenesis of Antibiotic Substances covers the proceedings of a panel discussion on ""Basic Research and Practical Aspects of Antibiotic Production"" held during the Antibiotic Congress in Prague. This book is organized into 25 chapters that cover the regulating mechanisms of primary antibiotic metabolite biosynthesis. This text describes the relationship between secondary metabolite production and synthesis of cell matter or cell wall. The opening chapters describe the parasexual cycle and some of the ways in which the cycle may be used for strain improvement, as well as the applications of refined techniques of genetic recombination and the principles of biochemical genetics to the field of antibiotics. The next chapter deals with cultural and fermentative characteristics of A-type isolates obtained from progenitor and representative member strains of the Wisconsin Family of Strains of Penicillium chrysogenum. Considerable chapters are devoted to the metabolite biosynthesis, such as geodoxin and related compounds; secondary metabolism of penicillins, gibberellins, and griseofulvin in fungi; and tetracycline metabolites. The book goes on examining the stereochemical aspects of macrolide antibiotics. It also describes the biosynthetic pathways involving ring cleavage of carbocyclic compounds, as well as the biosynthesis of different peptide antibiotics and of actinomycins and its relationship to protein synthesis. The production of phenazines is also explained. Other chapters consider other metabolites, such as those that decarboxylate, the malonate, and the 3-nitropropionic acid. A discussion on the role of carbohydrates and phosphate in the biosynthesis of different types of antibiotics is included. Lastly, microbiological assay procedures for antibiotic research and influencing factors are presented.
Preface
Contributors
Chapter 1 About Mechanisms Regulating the Biosynthesis of Secondary Metabolites
Chapter 2 Fungal Genetics and Strain Improvement
Chapter 3 Possible Applications of Formal and Biochemical Genetics to the Field of Antibiotics
Chapter 4 On the Basic Trend of Genetical Studies and Breeding Program of Antibiotic-Producing Organisms
Chapter 5 The A-Type Variant Colony of Penicillium chrysogenum Strains and Antibiotic Production
Chapter 6 The Biosynthesis of Geodoxin and Related Compounds
Chapter 7 Aspects of Secondary Metabolism in Fungi
Chapter 8 Biosynthesis of the Tetracyclines
Chapter 9 The Carbohydrate Metabolism of Producing Microorganisms and the Biosynthesis of Tetracycline Antibiotics
Chapter 10 Basic Stereochemical Research Topics in the Macrolide Antibiotics
Chapter 11 Speculation on the Origin of Macrolide Antibiotics
Chapter 12 Reflections on the Fungal Formation of Acetate-Derived Metabolites
Chapter 13 Biosynthetic Pathways Involving Ring Cleavage
Chapter 14 Problems Relating to the Biosynthesis of Peptide Antibiotics
Chapter 15 The Biosynthesis of the Actinomycins and its Relationship to Protein Synthesis
Chapter 16 The Production of the Phenazines by Actinomycetes
Chapter 17 Amino- and Nitrobenzoic Acid Metabolism in Actinomycetes and Its Influence on Synthesis of Antibiotics
Chapter 18 The Role of Decarboxylation in the Secondary Metabolism of Molds
Chapter 19 Studies on the Basic Metabolism Determining the Biosynthesis of Malonate Derived Compounds in Penicillium islandicum
Chapter 20 Origin of 3-Nitropropionic Acid in Fungi
Chapter 21 A Mechanism of Energy Control on the Biosynthesis of Hydroxystreptomycin
Chapter 22 Comments on the General Role of Carbohydrates in Antibiotic Synthesis
Chapter 23 Microbiological Assay Procedures for Special Problems in Antibiotic Research
Chapter 24 Empiricism in the Determination of Preferred Metabolic Conditions
Chapter 25 Discussion
Author Index
Microorganism Index
Compound Index
Subject Index
- Edition: 1
- Published: January 1, 1965
- No. of pages (eBook): 324
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780124332751
- eBook ISBN: 9780323155830
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