Biochemistry of Cancer

ContentsChapter I. Introduction — The Oncological Sciences Chapter II. The General Phenomena and Taxonomy of Cancer Introduction Definition and Some Characteristics of Tumors Classification of Animal Tumors Transmissibility of Tumors and the Experimental Basis of Cancer Research Experimental Induction of Tumors Cancerous Transformation of Animal Tissues in Vitro Growth and the Vascular Reactions of Tumors Plant Tumors Fish Tumors Tissue Immunity Reactions References The Induction of Tumors Chapter III. Extrinsic Factors Introduction The Carcinogenic Action of Coal Tar The Polycyclic Hydrocarbons Comparative Carcinogenicity of the Hydrocarbons The Relative Susceptibility of Mice Strains to the Polycyclic Hydrocarbons Metabolic Fate of Injected Hydrocarbons Dosage of and Response to the Carcinogenic Hydrocarbons The Influence on Carcinogenicity of Concomitant Materials The Azo Dyes The Metabolism of p-Dimethylaminoazobenzene Halogenated Aliphatic Hydrocarbons N-Acetyl-2-Aminofluorene Ultraviolet Light as a Carcinogenic Agent The Effect of Carcinogenic Agents in Various Species Relation Between Induced and Spontaneous Tumors Environmental Factors as Carcinogenic Agents References Chapter IV. Intrinsic Factors Introduction Influence of Sex Hormones on Carcinogenesis of Sex and Accessory Sex Tissues Influence of Sex Hormones on Carcinogenesis of Non-Sex Tissues The Mammary Tumor Inciter for Mice Viruses as Causative Agents for Fowl Tumors and Rabbit Papillomas The Possibility of Relatively Non-Specific Endogenous Carcinogens ReferencesAttempts at Control of Tumor Induction and of Tumor Growth Chapter V. Nutrition Introduction Induction of Mammary Tumors in Mice Dietary Deficiency and Hormone Inhibition Induction of Tumors other than Mammary Diet and Different Stages of Carcinogenesis Diet and the Established Tumor References Chapter VI. Endocrinology Introduction Mammary Tumors in Mice Leukemia in Mice Carcinoma of the Prostate in Man References Chapter VII. Chemotherapy Introduction Bacterial Metabolites Benzene and Arsenite Radioactive Isotopes Colchicine References The Properties of Tumors Chapter VIII. Chemistry of Tumors Introduction Chemical Concentration or Activity and the Proportion of Active Epithelial Cells in Tumors The Metabolism of Normal Tissues, of Primary Tumors and of Transplanted Tumors The Chemical Pattern of Normal and of Neoplastic Tissues General Conclusions Conclusions Relating to Special Systems The Overall Enzyme Pattern The Properties of Homologous Hepatic Tissues The Oxidative Response of Normal and Neoplastic Tissues Glycolytic Reactions in Normal and Neoplastic Tissues Proteins in Normal and Neoplastic Tissues Correlation of Metabolism of Normal and Tumor Tissues with Concentration of Crucial Components Melanotic and Amelanotic Melanomas Strain Differences in Mice Tumors and the Problem of Synthesis Chemical Constitution of Tumors and the Problem of Therapy References Chapter IX. Chemistry of the Tumor-bearing Host Introduction Specific Systems Hepatic Dysfunction in Man Hepatic, Renal and Blood Catalase Activity Hepatic and Renal d-Amino Acid Oxidase Hepatic and Renal Arginase Hepatic Riboflavin Tissue Esterase and Lipase Tissue Lipoids and Steroids Water Content Copper Muscle Nucleophosphatase Hepatic Tissue Glycolysis in Leukemia Tissue Components of Cancerous Hosts Which Do Not Apparently Alter from Normal Hemoglobin Concentration Blood Proteose Serum Zymohexase Plasma Prothrombin Serum Phosphatase (Monoesterase) Serum Phosphatase Levels in Prostatic Carcinoma Serum Alkaline Phosphatase in Neoplastic Involvement of the Liver Serum and Blood Esterase and Lipase Urinary Steroids Summary of Data Effect of Serum on Isolated Enzyme Systems Bence-Jones Proteins References Chapter X. The Present Status of the Problem Experimental and Clinical Cancer Research Author Index Subject Index