Biochemical Actions of Hormones V5
- 1st Edition - January 28, 1978
- Imprint: Academic Press
- Editor: Gerald Litwack
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 1 4 5 5 2 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 4 8 7 1 - 9
Biochemical Actions of Hormones, Volume V explores the nature of interaction of multiple hormones in regulating specific phenotypes. This volume is organized into 11 chapters that… Read more
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Request a sales quoteBiochemical Actions of Hormones, Volume V explores the nature of interaction of multiple hormones in regulating specific phenotypes. This volume is organized into 11 chapters that include discussions on the developments in the understanding of the biochemistry and molecular biology of hormones. The opening chapters deal with the modifications of chromatin structure by hormones, the regulation of exocytosis, ontogeny of estrogen receptors, and the hormonal regulation of cells of the seminiferous tubule. The discussions then shift to the advances on the progesterone receptor, the role of glucocorticoids in the integration of mammary tumor virus genes, and a model system for estrogen action. Other chapters examine the physiology, molecular action, and biological effects of somatomedins, epidermal growth factors and 1,25-dihydroxyvitamin. The remaining chapters focus on multihormone control of mRNA for a specific hepatic protein. This book is of great value to endocrinologists.
List of Contributors
Preface
Contents of Previous Volumes
1. Postsynthetic Modifications of Histone Primary Structure: Phosphorylation and Acetylation as Related to Chromatin Conformation and Function
I. Introduction
II. Histone Phosphoryfotion
III. Histone Acetylation
IV. Histone Modifications and Chromatin Structure
References
2. Regulation of Exocytosis
I. Introduction
II. Steps in the Secretory Process
III. Possible Mechanisms of Cell Membrane Fusion
IV. Sites of Fusion between Plasma and Secretory Granule Membranes
V. An Electrostatic Function for Calcium in Exocytosis
VI. Coupling of Endocytosis with Exocytosis
VII. Release of Secretory Granule Contents in a Cell-Free System
VIII. The Role of Calcium in Secretory Processes
IX. Microtubules and Contractile Proteins
X. Abnormalities in Exocytosis
XI. Sulfhydryl Groups and Secretory Processes
XII. A Possible Mechanism for the Regulatory Role of Calcium in Exocytosis
XIII. Summary
References
3. The Somatomedins and Their Actions
I. Introduction
II. History of the Somatomedins
III. Isolation and Chemistry of the Somatomedins
IV. Origin and Degradation of the Somatomedins
V. In Vitro Biological Effects of the Somatomedins
VI. Interactions of the Somatomedins with Specific Somatomedin Receptors
VII Physiological Regulation of the Somatomedins
VIII. Concluding Remarks
References
4. The Ontogeny of Estrogen Receptors
I. Introduction
II. Mammalian Reproductive Tract
III. The Mammalian Neuroendocrine System
IV. Mammalian Visceral Organs
V. The Chick Embryo
VI. Concluding Remarks
References
5. Epidermal Growth Factors
I. Introduction
II. Isolation of Epidermal Growth Factors
III. Chemical and Physical Properties of EGF
IV. Control of EGF Levels and Secretion in the Submaxillary Gland of the Mouse
V. Biological Activity of EGF In Vivo
VI. Biological Activity of EGF in Organ Culture
VII. Biological Activity of EGF in Cell Culture
VIII. Interaction of 125I-Labeled EGF with Biological Material
IX. Epilogue
References
6. Sites of Action of Androgens and Follicle Stimulating Hormone on Cells of the Seminiferous Tubule
I. Introduction and Perspectives
II. Evidence that Androgen Influences on Spermatogenesis are Mediated via Direct Effects on Testicular Somatic Cells and Not on Germinal Cells
III. Responses of Testicular Somatic Cells in the Seminiferous Tubule to Androgens and FSH
IV. Speculations on Mechanisms by Which Testicular Somatic Cells May Influence Germinal Cell Development
References
7. Biochemical Properties of the Intestinal Receptor System for the Steroid Hormone 1,25-Dihydroxyvitamin D
I. Introduction
II. Biochemical Properties of Intestinal Receptor System
III. Structure-Function Studies
References
8. The Chick Oviduct Progesterone Receptor
I. Introduction
II. Oviduct Progesterone Receptor-Hormone Interactions
III. Enzymatic and Binding Activities of the Chick Oviduct Progesterone Receptor
IV. Progesterone Receptor Forms
V. Characteristics of Receptor Aggregate Forms
VI. Progesterone Receptor Interaction with Nuclear Components
VII. Effects of the Chick Oviduct Progesterone Receptor on Transcription
VIII. Molecular Model of Steroid Hormone Action
IX. Future Directions
References
9. Integrated Mammary Tumor Virus Genes: Transcriptional Regulation by Glucocorticoids and Specific Effects on Host Gene Expression
I. Mammary Tumor Virus DNA as a Specific Genetic Probe
II. RNA Synthesis in Isolated GR Cell Nuclei
III. Responsiveness of MTV Genes in Infected HTC Cells
IV. Altered Host Gene Expression in Infected HTC Cells
V. MTV and Transposable Genetic Elements
References
10. Induction and Regulation of Vitellogenin Synthesis by Estrogen
I. Introduction
II. Vitellogenin
III. Physiology of Vitellogenesis
IV. Protein Synthesis in the Liver during Vitellogenin Induction
V. Translational Control and Posttranslational Modifications of Vitellogenin
VI. Estradiol Receptors and the Expression of the Vitellogenin Gene
References
11. Multihormonal Control of the Messenger RNA for the Hepatic Protein Globulin
I. Introduction
II. α2U Globulin
III. Effect of Thyroid Hormones on α2u Globulin Synthesis and α2u Globulin mRNA
IV. Effects of Sex Hormones on α2u Globulin Synthesis and mRNA
V. Effects of Other Hormones on α2u Globulin Synthesis and mRNA
VI. α2u Globulin Synthesis in Isolated Hepatocyte Suspensions
VII. α2u Globulin Synthesis in Hepatomas
VIII. Conclusions
References
Index
- Edition: 1
- Published: January 28, 1978
- No. of pages (eBook): 482
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780124145528
- eBook ISBN: 9780323148719
GL
Gerald Litwack
Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.
Affiliations and expertise
Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA, USARead Biochemical Actions of Hormones V5 on ScienceDirect