Bioactive Materials for Soft Tissue Regeneration

1st Edition - June 4, 2024
Editors: Jiang Chang, Bin Li, Chengtie Wu
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 9 9 8 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 3 2 4 - 2

Bioactive Materials for Soft Tissue Regeneration covers human tissue and its classification as hard tissue such as bone and soft tissue like skin, muscle, tendon, blood vessel, n… Read more

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Bioactive Materials for Soft Tissue Regeneration covers human tissue and its classification as hard tissue such as bone and soft tissue like skin, muscle, tendon, blood vessel, nerve etc., and including organs such as heart, liver, lung. Regenerative medicine deals with both hard tissue and soft tissue regeneration and is one of the most important part of the modern medicine with significant clinical needs including general surgery, plastic surgery, burn and wound healing, cardiovascular disease treatments. Based on the authors’ previous research and review of the international advances in hard tissue regeneration, this book focuses on the hard tissue regeneration using bioactive materials.

Sections cover biomaterials for entire human tissue regeneration, which is key important for research and development in the field of biomedical engineering and the medical device industry. Readers will find this to be a comprehensive review of the most updated advances of the research in bioactive materials for soft tissue repair and regeneration, along with perspectives for future directions of research and development in this field.

1. Introduction biomaterials

2. Biological effect of materials chemistry on soft tissue regeneration

2.1. Introduction 2.2. Fabrication of biomaterials with different chemical composition 2.2.1. Polymer materials with bioactive modification 2.2.2. Bioceramics and bioactive glasses with different chemical composition 2.3. Bioactive effect of materials with different chemical composition 2.3.1. Regulation of cellular activity by biomaterials with different chemical composition 2.3.1.1. Regulation of stem cells by biomaterials with different chemical composition 2.3.1.2. Regulation of tissue specific cells by biomaterials with different chemical composition 2.3.1.3. Regulation of macrophages by biomaterials with different chemical composition 2.3.2. Soft tissue regeneration regulated by biomaterials with different chemical composition 2.4. Multi-functional biomaterials with different functional components for soft tissue regeneration 2.5. Concluding remarks References

3. Biological effect of materials structure on soft tissue regeneration

3.1. Introduction 3.2. Fabrication of biomaterials with multi-scale structure 3.2.1. Fabrication of biomaterials with micro-scale structure 3.2.2. Fabrication of biomaterials with nano-scale structure 3.3. Effect of materials structure on tissue regeneration 3.3.1. Effect of microstructure on cellular activity 3.3.1.1 Regulation of stem cells by materials structure 3.3.1.2 Regulation of tissue specific cells by materials structure 3.3.1.3. Regulation of macrophages by materials structure 3.4. Effect of multi-scale structure on tissue regeneration 3.5. Concluding remarks References

4. Biological effects of material mechanics and its application in soft tissue regeneration

4.1 Introduction 4.2. Biomaterials with adjustable mechanics 4.2.1. 2D materials 4.2.2. 3D materials 4.2.3 Gradient materials 4.3. Effect of material mechanics on cell adhesion, spreading, migration and proliferation 4.3.1 Stiffness 4.3.2 Viscoelasticity 4.4. Effect of material mechanics on cell differentiation 4.4.1 Stiffness 4.4.2 Viscoelasticity 4.5. Molecular basis of cellular modulation by mechanics 4.5.1 Matrix stiffness and viscoelasticity 4.5.2 Other modulation factors through mechanotransduction (Topography, chemical composition, mechanical stress?) 4.6. Regeneration of soft tissues by material mechanics 4.6.1 Cartilage 4.6.2 Nerve 4.6.3 Blood vessel 4.6.4 Intervertebral disc 4.6.4 Other tissues (skin, tendon/ligament…) 4.7. Concluding remarks References

Jiang Chang

Jiang Chang is a professor at the Shanghai Institute of Ceramics, Chinese Academy of Sciences, China, and an Associate of the University of Manitoba Transport Institute. He is one of the leading young scholars worldwide in the field of transport economics and policy in the sectors of aviation, rail and maritime. He has received numerous prestigious accolades such as the Associates’ Achievement Award for Outstanding Business Research. His research focuses on bioactive materials for tissue regeneration and tissue engineering and the mechanisms of the interaction between biomaterials and cells. Professor Chang has over 300 scientific papers published in international peer-reviewed scientific journals and 70 patents in the field of biomedical materials.

Affiliations and expertise

Assistant Professor, Transport and Supply Chain Management, University of Manitoba, Canada

Bin Li

Bin Li is a professor and serves as the chair of the Membership Committee of the International Chinese Musculoskeletal Research Society. His research interests include orthopedic biomaterials, stem cells and tissue engineering, smart molecular recognition and controlled release, surface modification and functionalization, cellular biomechanics, and mechanobiology.

Chengtie Wu

Prof. Chengtie Wu is now working at Shanghai Institute of Ceramics, Chinese Academy of Sciences (SIC, CAS). He completed his Ph.D in 2006, and then he worked in the University of Sydney, Queensland University of Technology and Dresden University of Technology where he was awarded Vice-Chancellor Research Fellow and Alexander von Humboldt Fellow. In 2012, Dr Wu has been recruited to work in SIC, CAS. Prof Wu’s research focuses on 3D Printing of Bioactive Inorganic Materials for Tissue Engineering. Up to now, Prof Wu has published more than 200 SCI peer-review journal papers. He is now the Associate editors for “Applied Materials Today” and “Journal of Inorganic Materials”, as well as the editorial board member of “Acta Biomaterialia”.

Affiliations and expertise

Shanghai Institute of Ceramics, Chinese Academy of Sciences (SIC, CAS), Shanghai, People's Republic of China

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health