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Elsevier

Bioactive Compounds

Mechanisms, Challenges and Strategies for Bioaccessibility and Bioavailability

  • 1st Edition - March 1, 2027
  • Latest edition
  • Editors: Cristobal Noe Aguilar, Eliseo Cárdenas Hernández, Rafael Matos Ximenes, Jose Sandoval Cortes
  • Language: English

Bioactive Compounds: Mechanisms, Challenges and Strategies for Bioaccessibility and Bioavailability covers nutrition, food science, and pharmacology, elucidating the intric… Read more

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Description

Bioactive Compounds: Mechanisms, Challenges and Strategies for Bioaccessibility and Bioavailability covers nutrition, food science, and pharmacology, elucidating the intricate dynamics of bioactive compounds and their impacts on human health. This comprehensive volume delineates the crucial differences between bioaccessibility and bioavailability, providing insights into their implications for health outcomes. Readers will explore the behavior of key classes of bioactive compounds, including polyphenols, carotenoids, and peptides, as well as their sources and interactions within the food matrix. The book further examines the essential role of gut microbiota in absorption processes, highlighting how these interactions can influence bioactive compound efficacy in the human body.

Sections not only discuss the mechanisms of absorption, distribution, metabolism, and excretion (ADME) of bioactive compounds but also introduce cutting-edge tools and strategies designed to enhance their bioaccessibility and bioavailability.

Key features

  • Delineates the differences between bioaccessibility and bioavailability, along with their implications for health outcomes
  • Highlights the impact of the interaction of the main classes of bioactive compounds such as polyphenols, carotenoids, and peptides while addressing their sources and behavior within the food matrix
  • Discusses the role of the gut microbiota in the absorption processes of bioactive compounds
  • Introduces tools and strategies to improve bioaccessibility and bioavailability, including microfluidics and nanotechnology
  • Provides insights into bioactive compounds' bioaccessibility, bioavailability, health effects, absorption, and metabolism function

Readership

Researchers in the food sciences studying nutrition, bioactive compounds, nutraceuticals and functional foods. Clinicians, food chemists, pharmacologists and food biochemists

Table of contents

Section 1: Foundations of Bioactive Compounds

1. Introduction

2. Bioactive Compounds: Sources and Their Benefits to Human Health

3. Bioactive Compound Delivery Systems: Foods, Plant Matrices, Functional Foods, and Nutraceuticals

4. Bioaccessibility, Bioavailability and Bioactivity: Clarification of the Concepts, Key Challenges, and Future Directions

Section 2: Mechanisms of Absorption and Impact on Health

5. Process of Absorption, Distribution, Metabolism, and Excretion (ADME) of Bioactive Compounds

6. Impact of the Interaction of Bioactive Compounds within the Food Matrix on Their Bioaccessibility, Bioactivity, and Bioavailability

7. Role of the Gut Microbiota in the Absorption Processes of Bioactive Compounds

8. Human biochemistry of absorption and biotransformation of bioactive compounds: clinical trials and physiological applications

9. Influence of bioaccessibility and bioavailability on human health: role in the prevention and management of chronic diseases

Section 3: Factors Affecting Bioaccessibility and Bioavailability

10. Factors That Affect the Bioaccessibility and Bioavailability of Bioactive Compounds

11. Methods for the Determination of Bioaccessibility and Bioavailability of Bioactive Compounds: Traditional Approaches, Microfluidic and New Techniques

12. Strategies and Delivery Systems to Improve Bioaccessibility and Bioavailability of Bioactive Compounds: Limitations, Micro and Nanoencapsulation

Section 4: Innovative Approaches and Future Directions

13. In Vivo, In Vitro, or In Silico Tools for Predicting Pharmacokinetics of Bioactive Compounds

14. Can Informatics, Bioinformatics, and Artificial Intelligence Tools Help in the Study of Bioaccessibility and Bioavailability?

15. Innovative Product Development for Enhancing Bioaccessibility and Bioavailability of Bioactive Compounds: Practical Examples and Applications

Product details

  • Edition: 1
  • Latest edition
  • Published: March 1, 2027
  • Language: English

About the editors

CA

Cristobal Noe Aguilar

Prof. Dr. Cristobal N. Aguilar, Chemist, PhD, was the Director of the Research and Postgraduate Programs at Autonomous University of Coahuila (2018–2024, Mexico, where from 2014 to 2018, he was the Dean of the School of Chemistry. He is a Level III member of S.N.I. (Mexican System of Researchers). He has received several prizes and awards, among which the most important are the National Prize of Research 2010 of the Mexican Academy of Sciences, the Prize “Carlos Casas Campillo 2008” of the Mexican Society of Biotechnology and Bioengineering, the National Prize AgroBio–2005, the Mexican Prize in Food Science and Technology from CONACYT-Coca Cola México 2003, the 2018 Outstanding Researcher Award by the International Association of Bioprocessing, and the 2019 Coahuila State Innovation Science and Technology Award. He's developed more than 30 research projects, including seven international exchange projects. He is a member of the Mexican Academy of Science (since 2014).
Affiliations and expertise
Autonomous University of Coahuil, Saltillo, Mexico

EH

Eliseo Cárdenas Hernández

Eliseo Cárdenas Hernández is a Pharmaceutical Chemist Biologist from the Autonomous University of Coahuila (UAdeC), Mexico. He obtained his master's degree in Food Science and Technology from UAdeC and a master's degree in Biological Sciences from the Federal University of Pernambuco, Brazil. He is a PhD student at the same program. He is a candidate for State Researcher by COECYT, Mexico and is a member of the Mexican Association of Food Science. He obtained the Lobo Award of Excellence in Academic Activities of the UAdeC in 2021. In addition, due to his master’s studies, he was recognized with the “Juan Antonio de la Fuente” Medal (UAdeC) in 2024.

His scientific productivity includes several articles and book chapters. Also, he is a peer reviewer for the international journals Heliyon and Journal of Cleaner Production of Elsevier, and has actively participated in national and international congresses as part of the organizing committee, speaker or assistant.

Affiliations and expertise
Department of Food Research, Faculty of Chemistry, Universidad Autónoma de Coahuila, México

RX

Rafael Matos Ximenes

Prof. Dr. Rafael Matos Ximenes is a pharmacist with an MSc and PhD in Pharmacology. He has been a Full-time Professor at the Centre for Biosciences at the Federal University of Pernambuco (UFPE), Brazil, for the past decade. During this time, he also served as a visiting researcher at the University of Nantes, France, and the University of Seville, Spain. At UFPE, he was Chair of the Doctoral School of Biotechnology (2019–2023) and Vice-Chair of the Doctoral School in Pharmaceutical Sciences (2016–2017). As the Principal Investigator of the Research Group on Ethnopharmacology and Phytochemistry, his work focuses on the intersection of food and drugs, particularly exploring bioactive compounds from Amazon and Caatinga biodiversity for the prevention and treatment of immuno-mediated chronic inflammatory diseases. Throughout his career, he has supervised 12 PhD theses and 10 MSc theses and has published more than 65 papers in international indexed journals.

Affiliations and expertise
Department of Antibiotics, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil

JC

Jose Sandoval Cortes

Jose Sandoval Cortes is a Chemist, PhD, and full-time Professor at the School of Chemistry, Autonomous University of Coahuila, Mexico, for the last 12 years. He worked in a research stay in electrochemistry at the University of Paris 6 Pierre et Marie Curie, France; the National University of Cordoba, Argentina; and the National University of Rio Cuarto, Argentina. His research work has been published in six papers in indexed journals, three book chapters, and 20 contributions at scientific meetings. Since 2018, he has been part of the administrative staff of the Research and Postgraduate Studies Office at the Autonomous University of Coahuila. He received the Pharmaceutical Chemist Biologist degree in 2001, the MSc degree in chemistry in 2003, and the PhD degree in electrochemistry in 2006 from the University of Guanajuato, Mexico.
Affiliations and expertise
Professor, School of Chemistry, Autonomous University of Coahuila, Mexico