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Berne & Levy Physiology
- 8th Edition - February 12, 2023
- Authors: Bruce M. Koeppen, Bruce A. Stanton
- Editors: Julianne M Hall, Agnieszka Swiatecka-Urban
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 4 7 9 0 - 2
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 4 7 9 1 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 4 7 9 2 - 6
Pairing necessary detail with concise readability, Berne & Levy Physiology, 8th Edition, provides a perfect balance of content to deliver an in-depth understanding of the bo… Read more
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Request a sales quotePairing necessary detail with concise readability, Berne & Levy Physiology, 8th Edition, provides a perfect balance of content to deliver an in-depth understanding of the body’s dynamic processes. Long respected for its scientifically rigorous approach, this highly regarded, mid-size text offers essential physiology with integrated coverage of biophysics andkey experimental observations and examples—all designed to provide a solid scientific foundation in physiology for future scientists and clinicians.
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Uses a logical, organ system-based approach that clearly describes all of the mechanisms that control and regulate bodily function.
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Includes new clinical case examples, as well as In the Clinic and At the Molecular Level boxes that highlight practical aspects of this fundamental science.
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Provides key experimental observations and examples that offer a rich understanding of the body's dynamic processes.
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Discusses recent discoveries such as the role of lymphatics in the nervous system.
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Begins each chapter with a bulleted list of questions and ends with key concepts covered in that chapter.
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
students of human physiology (undergrad [premed/preclinical], biomedical, bioscience, pharma, grad, medical, PA)
- Cover Image
- Title Page
- Copyright
- Dedication
- Section Authors
- Preface
- Note to Instructors
- Table of Contents
- Section 1 Cellular Physiology
- Chapter 1 Principles of Cell and Membrane Function
- Learning Objectives
- Overview of Eukaryotic Cells
- Vesicular Transport
- Electrochemical Gradient
- Osmosis and Osmotic Pressure
- Key Points
- Chapter 2 Homeostasis: Volume and Composition of Body Fluid Compartments
- Learning Objectives
- Concept of Steady-State Balance
- Volumes and Composition of Body Fluid Compartments
- Maintenance of Cellular Homeostasis
- Principles of Epithelial Transport
- Key Concepts
- Chapter 3 Signal Transduction, Membrane Receptors, Second Messengers, and Regulation of Gene Expression
- Learning Objectives
- Cell-to-Cell Communication
- Receptors
- Receptors and Signal Transduction Pathways
- Regulation of Gene Expression by Signal Transduction Pathways
- Key Points
- Section 2 Neurophysiology
- Chapter 4 The Nervous System: Introduction to Cells and Systems
- Learning Objectives
- Cellular Components of the Nervous System
- The Peripheral Nervous System
- The Central Nervous System
- Nervous Tissue Reactions to Injury
- Key Points
- Chapter 5 Generation and Conduction of Action Potentials
- Learning Objectives
- Membrane Potentials
- Suprathreshold Response: The Action Potential
- Conduction of Action Potentials
- Key Points
- Chapter 6 Synaptic Transmission
- Learning Objectives
- Electrical Synapses
- Chemical Synapses
- Synaptic Integration
- Modulation of Synaptic Activity
- Neurotransmitters
- Neurotransmitter Receptors
- Key Points
- Chapter 7 The Somatosensory System
- Learning Objectives
- Subdivisions of the Somatosensory System
- Discriminatory Touch and Proprioception
- Thalamic and Cortical Somatosensory Areas
- Pain and Temperature Sensation
- Transduction in the Somatosensory System
- Centrifugal Control of Somatosensation
- Key Points
- Chapter 8 The Special Senses
- Learning Objectives
- The Visual System
- The Auditory and Vestibular Systems
- The Chemical Senses
- Key Points
- Chapter 9 Organization of Motor Function
- Learning Objectives
- Principles of Spinal Cord Organization
- Descending Motor Pathways
- Brainstem Control of Posture and Movement
- Motor Control by the Cerebral Cortex
- Motor Control by the Cerebellum
- Motor Control by the Basal Ganglia
- Eye Movement
- Key Points
- Chapter 10 Integrative Functions of the Nervous System
- Learning Objectives
- The Cerebral Cortex
- Key Points
- Chapter 11 The Autonomic Nervous System and Its Central Control
- Learning Objectives
- Organization of the Autonomic Nervous System
- Autonomic Ganglia
- Neurotransmitters
- Central Control of Autonomic Function
- Key Points
- Section 3 Muscle Physiology
- Chapter 12 Skeletal Muscle Physiology
- Learning Objectives
- Skeletal Muscle Physiology
- Organization of Skeletal Muscle
- Control of Skeletal Muscle Activity
- Skeletal Muscle Types
- Modulation of the Force of Contraction
- Modulation of Force by Reflex Arcs
- Skeletal Muscle Tone
- Energy Sources During Contraction
- Oxygen Debt
- Fatigue
- Growth and Development
- Denervation, Reinnervation, and Cross-Innervation
- Response to Exercise
- Delayed-Onset Muscle Soreness
- Biophysical Properties of Skeletal Muscle
- Key Points
- Chapter 13 Cardiac Muscle
- Learning Objectives
- Basic Organization of Cardiac Muscle Cells
- Control of Cardiac Muscle Activity
- Regulation of the Force of Contraction
- Cardiac Muscle Metabolism
- Cardiac Muscle Hypertrophy
- Key Concepts
- Chapter 14 Smooth Muscle
- Learning Objectives
- Overview of Smooth Muscle
- Structure of Smooth Muscle Cells
- Control of Smooth Muscle Activity
- Innervation of Smooth Muscle
- Regulation of Contraction
- Regulation of Myoplasmic Calcium Concentration
- Development and Hypertrophy
- Synthetic and Secretory Functions
- Biophysical Properties of Smooth Muscle
- Key Points
- Section 4 Cardiovascular Physiology
- Chapter 15 Overview of Circulation
- Learning Objectives
- The Heart
- The Cardiovascular Circuit
- Blood Vessels
- Key Points
- Chapter 16 Elements of Cardiac Function
- Learning Objectives
- Overview of Cardiac Function
- Electrical Properties of the Heart
- Normal Sinus Rhythm
- Arrhythmogenic Mechanisms
- Electrocardiography
- Arrhythmias
- The Cardiac Pump
- Key Points
- Chapter 17 Properties of the Vasculature
- Learning Objectives
- Hemodynamics
- The Arterial System
- The Venous System
- Microcirculation and Lymphatic System
- Coronary Circulation
- Cutaneous Circulation
- Skeletal Muscle Circulation
- Cerebral Circulation
- Intestinal Circulation
- Hepatic Circulation
- Fetal Circulation
- Key Points
- Chapter 18 Regulation of the Heart and Vasculature
- Learning Objectives
- Regulation of Heart Rate and Myocardial Performance
- Nervous Control of the Heart Rate
- Regulation of Myocardial Performance
- Regulation of the Peripheral Circulation
- Key Points
- Chapter 19 Integrated Control of the Cardiovascular System
- Learning Objectives
- Regulation of Cardiac Output and Blood Pressure
- Vascular Function Curve
- Relating the Cardiac Function Curve to the Vascular Function Curve
- A More Complete Theoretical Model: The Two-Pump System
- Role of the Heart Rate in Control of Cardiac Output
- Ancillary Factors That Affect the Venous System and Cardiac Output
- Interplay of Central and Peripheral Factors in Control of the Circulation
- Key Points
- Section 5 Respiratory Physiology
- Chapter 20 Introduction to the Respiratory System
- Learning Objectives
- Lung Anatomical Structure/Function Relationships
- Circulatory Systems in the Lung
- Innervation
- Lung Embryology, Development, Aging, and Repair
- Key Points
- Chapter 21 Static Lung and Chest Wall Mechanics
- Learning Objectives
- Pressures in the Respiratory System
- How a Pressure Gradient Is Created
- Lung Volumes and Their Measurement
- Lung Volumes and Capacities
- Determinants of Lung Volume
- Pressure-Volume Relationships
- Lung Compliance
- Surface Tension and Surfactant
- Key Points
- Chapter 22 Dynamic Lung and Chest Wall Mechanics
- Learning Objectives
- Dynamic Lung Mechanics
- Work of Breathing
- Key Concepts
- Chapter 23 Ventilation, Perfusion, and Ventilation/Perfusion Relationships
- Learning Objectives
- Ventilation
- Dead Space Ventilation: Anatomical and Physiological
- Alveolar Ventilation
- Pulmonary Vascular Resistance
- Distribution of Pulmonary Blood Flow
- Active Regulation of Blood Flow
- Ventilation/Perfusion Relationships
- Arterial Blood Hypoxemia, Hypoxia, and Hypercarbia
- Low Ventilation/Perfusion
- Alveolar Hypoventilation
- Diffusion Abnormalities
- Mechanisms of Hypercapnia
- Effect of 100% Oxygen on Arterial Blood Gas Abnormalities
- Regional Differences
- Key Points
- Chapter 24 Oxygen and Carbon Dioxide Transport
- Learning Objectives
- Gas Diffusion
- Oxygen Transport
- Carbon Dioxide Transport
- Regulation of Hydrogen Ion Concentration and Acid-Base Balance
- Carbon Dioxide Dissociation Curve
- Key Points
- Chapter 25 Control of Respiration
- Learning Objectives
- Ventilatory Control: An Overview
- Response to Carbon Dioxide
- Control of Ventilation: The Details
- Exercise
- Abnormalities in the Control of Breathing
- Key Points
- Chapter 26 Host Defense and Metabolism in the Lung
- Learning Objectives
- Host Defense
- Epithelial Cells and Commensal Microbiota Protect the Lumen of the Airways
- Clinical Manifestations Associated With Abnormalities in Mucosal Innate and Adaptive Immunity
- Metabolic Functions of the Lung
- Key Points
- Section 6 Gastrointestinal Physiology
- Chapter 27 Functional Anatomy and General Principles of Regulation in the Gastrointestinal Tract
- Learning Objectives
- Functional Anatomy
- Regulatory Mechanisms in the Gastrointestinal Tract
- Response of the GI Tract to a Meal
- Key Concepts
- Chapter 28 The Cephalic, Oral, and Esophageal Phases of the Integrated Response to a Meal
- Learning Objectives
- Cephalic and Oral Phases
- Esophageal Phase
- Key Concepts
- Chapter 29 The Gastric Phase of the Integrated Response to a Meal
- Learning Objectives
- Functional Anatomy of the Stomach
- Gastric Secretion
- Digestion in the Stomach
- Gastrointestinal Motility
- Gastric Motility
- Key Concepts
- Chapter 30 The Small Intestinal Phase of the Integrated Response to a Meal
- Learning Objectives
- Gastric Emptying in the Small Intestinal Phase
- Carbohydrate Assimilation
- Protein Assimilation
- Uptake of Peptides and Amino Acids
- Lipid Assimilation
- Water and Electrolyte Secretion and Absorption
- Absorption of Minerals and Water-Soluble Vitamins
- Motor Patterns of the Small Intestine
- Key Concepts
- Chapter 31 The Colonic Phase of the Integrated Response to a Meal
- Learning Objectives
- Overview of the Large Intestine
- Key Concepts
- Chapter 32 Transport and Metabolic Functions of the Liver
- Learning Objectives
- Overview of the Liver and its Functions
- Structural Features of the Liver and Biliary System
- Bile Formation and Secretion
- Ammonia Handling by the Liver
- Clinical Assessment of Liver Function
- Key Concepts
- Section 7 Renal Physiology
- Chapter 33 Elements of Renal Function
- Learning Objectives
- Overview of Renal Function
- Functional Anatomy of the Kidneys
- Assessment of Renal Function
- Glomerular Filtration
- Renal Blood Flow
- Regulation of Renal Blood Flow and Glomerular Filtration Rate
- Key Points
- Chapter 34 Solute and Water Transport Along the Nephron: Tubular Function
- Learning Objectives
- Solute and Water Reabsorption Along the Nephron
- Regulation of NaCl and Water Reabsorption
- Key Points
- Chapter 35 Control of Body Fluid Osmolality and Volume
- Learning Objectives
- Control of Body Fluid Osmolality: Urine Concentration and Dilution
- Control of Extracellular Fluid Volume and Regulation of Renal NaCl Excretion
- Key Concepts
- Chapter 36 Potassium, Calcium, and Phosphate Homeostasis
- Learning Objectives
- K+ Homeostasis
- Regulation of Plasma [K+]
- Alterations in Plasma [K+]
- K+ Excretion by the Kidneys
- Cellular Mechanism of K+ Transport by Principal and Intercalated Cells in the DT and CCD
- K+ Excretion by the DT and CCD
- Overview of Calcium and Inorganic Phosphate Homeostasis
- Integrative Review of Parathyroid Hormone and Calcitriol on Ca++ and Pi Homeostasis
- Key Concepts
- Chapter 37 Role of the Kidneys in the Regulation of Acid-Base Balance
- Learning Objectives
- The HCO3− Buffer System
- Overview of Acid-Base Balance
- Net Acid Excretion by the Kidneys
- Response to Acid-Base Disorders
- Simple Acid-Base Disorders
- Key Concepts
- Section 8 Endocrine Physiology
- Chapter 38 Introduction to the Endocrine System
- Learning Objectives
- Configuration of Feedback Loops Within the Endocrine System
- Chemical Nature of Hormones
- Transport of Hormones in the Circulation
- Cellular Responses to Hormones
- Key Concepts
- Chapter 39 Hormonal Regulation of Energy Metabolism
- Learning Objectives
- Continual Energy Supply and Demand: The Challenge
- Integrated Overview of Energy Metabolism
- Pancreatic Hormones Involved in Metabolic Homeostasis During Different Metabolic Phases
- Hormonal Regulation of Specific Metabolic Reactions and Pathways
- Leptin and Energy Balance
- Key Concepts
- Chapter 40 Hormonal Regulation of Calcium and Phosphate Metabolism
- Learning Objectives
- Crucial Roles of Calcium and Phosphate in Cellular Physiology
- Hormonal Regulation of Calcium and Phosphate: PTH, Vitamin D, and FGF23
- Hormonal Effects on Target Organs
- Regulation of Bone Formation
- Integrated Physiological Regulation of Ca++/Pi Metabolism
- Key Concepts
- Chapter 41 The Hypothalamus and Pituitary Gland
- Learning Objectives
- Anatomy
- The Neurohypophysis
- The Adenohypophysis
- Key Concepts
- Chapter 42 The Thyroid Gland
- Learning Objectives
- Anatomy and Histology of the Thyroid Gland
- Thyroid Hormones
- Transport of Thyroid Hormones
- Cellular Entry and Peripheral Conversion of Thyroid Hormones
- Regulation of Thyroid Function
- Physiological Effects of Thyroid Hormone
- Key Concepts
- Chapter 43 The Adrenal Gland
- Learning Objectives
- Anatomy
- Adrenal Medulla
- Adrenal Cortex
- Key Concepts
- Chapter 44 The Male and Female Reproductive Systems
- Learning Objectives
- The Male Reproductive System
- The Female Reproductive System
- Mammogenesis and Lactation
- Menopause
- Key Concepts
- Acknowledgment
- Index
- No. of pages: 864
- Language: English
- Edition: 8
- Published: February 12, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780323847902
- Paperback ISBN: 9780323847919
- eBook ISBN: 9780323847926
JH
Julianne M Hall
AS
Agnieszka Swiatecka-Urban
BK
Bruce M. Koeppen
BS