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Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

  • 1st Edition, Volume 95 - November 20, 2010
  • Latest edition
  • Editor: Erkki Nissinen
  • Language: English

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapte… Read more

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Description

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

Key features

  • Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors
  • Preclinical models in COMT inhibitor devlopment
  • Transgenic COMT mice – latest information summarized
  • Chemistry of COMT inhibitors and their design with molecular modelling
  • COMT gene and its regulation and relation to dopamine related diseases
  • Role of cofactor SAM regulation in relation to homocysteine
  • Nonclinical and clinical safety of COMT inhibitors summarized
  • Future prospects of COMT inhibitors in Parkinson’s disease

Readership

Neuroscientists, neurologists, psychologists

Table of contents

  1. Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson’s disease with dual enzyme inhibition

    2. Erkki Nissinen

  2. The catechol-O-methyltransferase gene, its regulation and polymorphisms

    3. Elizabeth M. Tunbridge

  3. Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture?

    4. Timo T. Myöhänen & Pekka T. Männistö

  4. Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms

    5. Thomas Müller

  5. Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors

    6. Erkki Nissinen and Pekka T. Männistö

  6. The Chemistry of Catechol-O-methyltransferase Inhibitors

    7. David A. Learmonth, László E. Kiss and Patrício Soares-da-Silva

  7. Toxicology and safety of COMT inhibitors

    8. Kristiina Haasio

  8. Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment

    9. Concepció Marin, J.A. Obeso

  9. Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson’s disease

    10. Seppo Kaakkola

  10. Catechol-O-methyltransferase and pain

Oleg Kambur & Pekka T. Männistö

Product details

  • Edition: 1
  • Latest edition
  • Volume: 95
  • Published: November 20, 2010
  • Language: English

About the editor

Erkki Nissinen

Series Volume Editor
Affiliations and expertise
Orion Corporation, Espoo, Finland

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