Bacterial Survival in the Hostile Environment
- 1st Edition - September 28, 2022
- Editors: Ashutosh Kumar, Shivendra Tenguria
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 8 0 6 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 7 2 2 0 - 8
Variety of bacteria are present in our environment but only a few of these bacteria causes diseases in their hosts including humans. These bacteria face different stresses in the… Read more

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Request a sales quoteVariety of bacteria are present in our environment but only a few of these bacteria causes diseases in their hosts including humans. These bacteria face different stresses in the environment as well as inside the host and adapt number of strategies for their survival. In 5 parts Bacterial Survival in the Hostile Environment covers all tactics and strategies adopted by bacteria for their survival under stressed conditions and will be focused on mechanistic insights of pathogenic adaptations to host environments (acidic environment, microaerobic conditions, immune system stress, metal stress etc., modulation of host pathways by pathogens for survival, dormancy, drug tolerance and resistance, proteins for stress survival). The content also includes different adaptation mechanisms of extremophiles to extreme environment, provides a complete and globally available advance knowledge related to bacterial survival from different perspectives and reviews the knowledge gaps and future prospects in the field of microbial adaptation for sustainable development of in the field of infection biology and pharmaceutics.
- Provides in depth knowledge about pathogen biology and microbial adaptations, microbe-host interactions, impact of pathogens on host physiology, virulent factors produced by pathogens and pharmaceutical applications, mechanism of pathogenic virulent factors
- Covers all tactics and strategies adopted by bacteria for their survival under stressed conditions
- Focuses on mechanistic insights of pathogenic adaptations to host
- Includes different adaptation mechanisms of extremophiles to extreme environment
Researchers, Scientists, Microbiologists, Medical practitioners, Medical students, Biotechnologists, Bacteriologists and others in the field of infectious diseases; Industry professionals throughout the globe who aspire to work on the pathogen biology
- Cover Image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Chapter 1. Mycobacterium tuberculosis adaptation to host environment
- Abstract
- Introduction
- M. tuberculosis adaptation to host immune system and oxidative stress
- Strategies to counter microbicidal effect of myeloid cells
- Microenvironment modulation by M. tuberculosis
- M. tuberculosis adaptations to acidic environment of phagolysosomes
- Mycobacterial adaptations to hypoxic environment
- M. tuberculosis adaptations to subsist heat shock
- M. tuberculosis adaptation to metal stress
- Conclusion
- References
- Chapter 2. Modulation of host pathways by Mycobacterium tuberculosis for survival
- Abstract
- Introduction
- Modulation of glycolytic flux
- Endoplasmic reticulum stress
- Modulation in host mitochondria
- Apoptosis
- Necrosis
- Phagosome maturation
- Autophagy Regulation
- Conclusion
- References
- Chapter 3. Signaling nucleotides in bacteria
- Abstract
- Introduction
- cyclic-di-AMP
- (p)ppGpp
- cyclic-di-GMP
- Conclusions and perspectives
- References
- Chapter 4. The fish immune armaments in response to pathogen invasion—a tour inside the macrophages
- Abstract
- Introduction
- Immune organs and cell types of teleosts
- Characteristics of teleosts’ macrophages
- Phagocytosis by macrophages
- Antigen presentation by macrophages
- Subcellular crosstalk of teleost macrophages
- Modalities of cell death
- Immune evasion strategies of microbial pathogen
- Conclusion
- References
- Chapter 5. Essential proteins for the survival of bacteria in hostile environment
- Abstract
- Introduction
- Hostile environment outside human host: extreme temperature
- Hostile environment within the human host
- Evasion of innate immune response with bacterial proteins (H. pylori)
- Evasion of adaptive immune response (H. pylori)
- Evasion of innate immune response with bacterial proteins (S. typhimurium)
- Evasion of adaptive immune response (S. typhimurium)
- References
- Chapter 6. Kinases and phosphatases in bacterial survival in hostile environment
- Abstract
- Introduction
- Kinases and phosphatases in abiotic conditions
- Kinases and phosphatases in biotic conditions
- Two-component system in host immune evasion
- References
- Chapter 7. Antimicrobial resistance—a serious global threat
- Abstract
- Introduction
- Mechanism of action of probiotics, challenges faced, and their evolution
- Antimicrobial agents
- Action of antimicrobial agents
- Antimicrobial resistance
- Causes of antimicrobial resistance
- Mechanism of antimicrobial resistance
- Resistance versus persistence
- Transmission of resistance
- Spread of antimicrobial resistance
- Conclusion and future prospects
- References
- Chapter 8. Combination of virulence and antibiotic resistance: a successful bacterial strategy to survive under hostile environments
- Abstract
- Introduction
- Cross coselection
- Hypermutations
- Antibiotic tolerance and persistence
- Compensatory mutations
- Conclusion
- Acknowledgments
- References
- Chapter 9. Mechanisms of biofilm-based antibiotic resistance and tolerance in Mycobacterium tuberculosis
- Abstract
- Introduction
- What is biofilm?
- Origins of biofilm hypothesis
- Characteristics of biofilm
- How biofilm is formed?
- Quorum sensing
- Drug resistance mechanisms of biofilm
- References
- Chapter 10. Biofilms: cities of microorganisms
- Abstract
- Introduction
- History of biofilms
- How are biofilms formed?
- Impact of biofilms on human
- Biofilms and food sector
- Mechanisms used by various microorganisms to form biofilm
- Biofilm by pathogenic microorganisms
- Biofilm by beneficial microorganisms (probiotics)
- Strategies or future trends against biofilms
- Conclusion
- References
- Chapter 11. Biofilm: a coordinated response of bacteria against stresses
- Abstract
- Introduction
- Conclusion
- References
- Chapter 12. The bacterial communication system and its interference as an antivirulence strategy
- Abstract
- Introduction
- Quorum-sensing and quorum quenching
- The architecture of quorum-sensing circuits
- Quorum quenching
- Antivirulence strategies based on quorum quenching
- Is there resistance to quorum-sensing inhibitors?
- Conclusion
- Acknowledgments
- Conflict of interest
- Author contributions
- References
- Chapter 13. Microbial adaptations in extreme environmental conditions
- Abstract
- Introduction
- Applications of extremophiles/extremozymes
- Conclusion
- References
- Chapter 14. Adaptation strategies of piezophilic microbes
- Abstract
- Introduction
- Effects of pressure on microbial cells and macromolecules
- Adaptation mechanisms in the piezophiles
- Biotechnological applications
- Conclusion
- References
- Chapter 15. Survival and adaptation strategies of microorganisms in the extreme radiation
- Abstract
- Introduction
- Radiation and radio-resistance
- Role of ions in the radiation resistance
- DNA repair for the radiation survival
- Production of mycosporine-like amino acids
- Scytonemin biosynthesis and UV neutralization
- Bacterioruberin
- Radiation resistance in D. radiodurans
- Radiation resistance in eukaryotes
- Conclusion
- References
- Chapter 16. Adaptation strategies of thermophilic microbes
- Abstract
- Introduction
- Conclusion
- References
- Index
- Language: English
- Edition: 1
- Published: September 28, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323918060
- eBook ISBN: 9780323972208
AK
Ashutosh Kumar
Dr. Ashutosh Kumar is an active researcher and scientific writer in his field for over 14 years and presently working at Department of Microbiology, Tripura University (A Central University), Suryamaninagar, Agartala, Tripura, India. He received MSc and PhD degree in Biotechnology from University of Hyderabad, India. He did his postdoctoral research at TIFR-National Centre for Biological Sciences Bangalore, Indian Institute of Technology Delhi and Jamia Hamdard, New Delhi, India. He also worked as a Visiting Research Scientist at Robert Koch Institute Berlin, Germany. He has made significant contributions to the study of virulence mechanisms and strategies of survival, adaptation, and persistence of Mycobacterium tuberculosis. He was involved in identification of an enzyme from M. tuberculosis that promote biofilm formation and drugs that enhanced the potency of two current anti-tuberculosis antibiotics. He received many scholarships, awards, and fellowship during his education. He has many publications in international journals and books.
Affiliations and expertise
Tripura University (A Central University), Department of Microbiology, Suryamaninagar, Agartala, Tripura , IndiaST
Shivendra Tenguria
Dr. Tenguria is an active researcher and currently working as Project Scientist in Cedars-Sinai Medical Center, Los Angeles, CA USA. He has been actively involved in research and training of graduate and undergraduate students. He received his MSc in Life Sciences from University of Rajasthan, Jaipur and PhD in Biotechnology from University of Hyderabad, Hyderabad, India. He received his postdoctoral training from Purdue University, Indiana, USA and Cedars-Sinai Medical Center (UCLA), Los Angeles, California, USA. Currently, he is working in the area of molecular innate immunity to unravel molecular signaling mechanics for sensing danger (infectious pathogens) signals through cytosolic receptors of the innate immune system of human and mouse hosts. With his doctoral and postdoctoral fellowships and research in the area of host-microbe interactions, bacterial survival and pathogenesis, he made seminal contributions by publishing in international Jr (Cell Host-Microbe, Nature Commun, Frontiers).
Affiliations and expertise
Project Scientist, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center (UCLA), Los Angeles, CA, United StatesRead Bacterial Survival in the Hostile Environment on ScienceDirect