AUTOIMMUNE LIVER DISEASES: AUTOIMMUNE HEPATITIS, PBC, AND PSC, An Issue of Clinics in Liver Disease

1st Edition, Volume 28-1 - November 9, 2023
Editor: David Bernstein
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 1 4 5 - 6
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 1 4 6 - 3

In this issue of Clinics in Liver Disease, guest editor Dr. David E. Bernstein brings his considerable expertise to the topic of Autoimmune Hepatitis Including PBC and PSC. The… Read more

AUTOIMMUNE LIVER DISEASES: AUTOIMMUNE HEPATITIS, PBC, AND PSC, An Issue of Clinics in Liver Disease

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In this issue of Clinics in Liver Disease, guest editor Dr. David E. Bernstein brings his considerable expertise to the topic of Autoimmune Hepatitis Including PBC and PSC. The three main immune disorders that involve the liver are AIH, primary biliary cholangitis, and primary sclerosing cholangitis. As these autoimmune diseases can share symptoms, it is important for the hepatologist to have clinical knowledge of each and understand their differences and similarities. This issue addresses these variants and provides the reader with important information relating to pathology, diagnosis, and treatment.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Autoimmune Hepatitis: Epidemiology, Subtypes, and Presentation
Key points
Introduction
Epidemiology
Subtypes of autoimmune hepatitis
Clinical presentation
Summary
Disclosure
Autoimmune Hepatitis: Pathophysiology
Key points
Introduction
Autoantibodies
Histology of autoimmune hepatitis
Genetic factors of autoimmune hepatitis
Environmental factors of autoimmune hepatitis
Dysregulated immune system
Animal Models for Understanding the Pathophysiology of Autoimmune Hepatitis
Summary
Clinics care points
Funding
Diagnosis of Autoimmune Hepatitis
Key points
Introduction
Diagnostic subtypes
Diagnostic scoring systems
Autoimmune hepatitis autoantibodies
Histological findings
Interface hepatitis
Emperipolesis
Rosette formation
Features of autoimmune acute liver failure
Grading and staging fibrosis
Exclusion of atypical findings
Summary of histological findings
Diagnosis of overlap syndromes
Autoimmune hepatitis–primary biliary cirrhosis overlap syndrome
Autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome
Summary
Clinics care points
Treatment of Autoimmune Hepatitis
Key points
Introduction
Goals of treatment
Considerations before treatment
First-line treatment for autoimmune hepatitis
Clinics care points
Disclosures
Primary Biliary Cholangitis: Epidemiology, Diagnosis, and Presentation
Key points
Introduction
Epidemiology
Clinical presentation
Diagnosis
Summary
Clinics care points
Disclosure
Primary Biliary Cholangitis: Pathophysiology
Key points
Introduction
Biliary epithelial cells changes
Influencing factors
Summary
Clinics care points
Disclosures
Autoimmune Markers in Primary Biliary Cholangitis
Key points
Introduction/background
Summary
Clinics care points
Disclosures
Treatment of Primary Biliary Cholangitis including Transplantation
Key points
Current approved primary biliary cholangitis therapy
Liver transplant in primary biliary cholangitis
Recurrent primary biliary cholangitis
Management of specific primary biliary cholangitis symptoms
Summary
Systemic Complications of Primary Biliary Cholangitis
Key points
Introduction
Discussion
Clinics care points
Disclosure
Primary Sclerosing Cholangitis: Epidemiology, Diagnosis, and Presentation
Key points
Background
Epidemiology
Presentation
Diagnosis
Summary
Clinics care points
Phenotypes of Primary Sclerosing Cholangitis and Differential Diagnosis
Key points
Introduction, history, and background
Definitions and diagnosis of primary sclerosing cholangitis
Phenotyping by anatomic distribution
Inflammatory bowel disease-associated
Immunoglobulin G subclass 4-associated sclerosing cholangitis
Autoimmune overlap syndromes
Differential diagnosis of sclerosing cholangitis
Discussion and summary
Clinics care points
Disclosure
Diagnostic Tests in Primary Sclerosing Cholangitis: Serology, Elastography, Imaging, and Histology
Key points
Introduction
Serology
Elastography
Imaging
Liver histology
Diagnostic approach
Discussion
Clinics care points
Disclosure
Treatment of Primary Sclerosing Cholangitis Including Transplantation
Key points
Introduction
Discussion
Endoscopic therapy
Liver transplantation for primary sclerosing cholangitis
Summary
Clinics care points
Cholangiocarcinoma Surveillance Recommendations in Patients with Primary Sclerosing Cholangitis
Key points
Introduction
Cholangiocarcinoma in the setting of primary sclerosing cholangitis
Diagnosis of cholangiocarcinoma in the setting of primary sclerosing cholangitis
Surveillance for cholangiocarcinoma in the setting of primary sclerosing cholangitis
Summary
Disclosure
Post-Transplant Management and Complications of Autoimmune Hepatitis, Primary Biliary Cholangitis, and Primary Sclerosing Cholangitis including Disease Recurrence
Key points
Introduction
Post-Transplant Complications: Rejection
Post-Transplant Complications: Recurrent Disease
Other Post-Transplant Complications
Post-Transplant Management
Summary
Clinics care points
Conflicts of interest
Financial support

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AUTOIMMUNE LIVER DISEASES: AUTOIMMUNE HEPATITIS, PBC, AND PSC, An Issue of Clinics in Liver Disease

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David Bernstein