Autoimmune Diseases In Domestic Animals

1st Edition - June 5, 2022
Author: Ian R Tizard
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 4 8 1 3 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 4 8 1 4 - 5

With nearly 100 different autoimmune diseases reported to occur in domestic animal species, this evidence-based clinical reference is a must-have for every veterinary practice! Au… Read more

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With nearly 100 different autoimmune diseases reported to occur in domestic animal species, this evidence-based clinical reference is a must-have for every veterinary practice! Autoimmune Diseases in Domestic Animals, from noted veterinary author Ian R. Tizard, sheds light on both common and rare conditions, including skin diseases, diabetes mellitus, thyroiditis, and hemolytic anemia. Convenient and portable, this single-source review addresses autoimmune diseases in dogs, cats, horses, and livestock species with comprehensive coverage of treatment protocols, diagnostic procedures, and the latest pathogenesis studies.

Cover Image
Title Page
Copyright
Dedication
Acknowledgments
Preface
Table of Contents
Abbreviations and Acronyms
Chapter 1 Basic Immunology: A Review
Chapter Outline
Innate Immunity
Step 3: B- and T-Cell Responses
The Complement System
Regulatory T Cells
Sources of Additional Information
Chapter 2 Immunologic Tolerance
Chapter Outline
Tolerance
Central Tolerance
Peripheral Tolerance
Regulatory Cells
Sources of Additional Information
Chapter 3 Loss of Tolerance
Chapter Outline
Witebsky’s Postulates
Normal Immune Responses
Abnormal Immune Responses
Sources of Additional Information
Chapter 4 Genetic Factors in Autoimmunity
Chapter Outline
MHC Genes
Genetic Predisposition to Autoimmunity
Monogenic Diseases
Sources of Additional Information
Chapter 5 The Microbiota and Autoimmunity
Chapter Outline
The Hygiene Hypothesis
The Normal Microbiota
Immunosuppression
The Microbiota and Autoimmunity
Sources of Additional Information
Chapter 6 Autoimmune Endocrine Diseases
Chapter Outline
Lymphocytic Thyroiditis
Lymphocytic Parathyroiditis
Type 1 Diabetes Mellitus
Autoimmune Adrenalitis
Autoimmune Hypophysitis
Autoimmune Polyendocrine Syndromes
Sources of Additional Information
Chapter 7 Autoimmune Neurologic Diseases
Chapter Outline
Peripheral Nervous System
Polyneuritis
CENTRAL NERVOUS SYSTEM
Other Neurologic Diseases
Sources of Additional Information
Chapter 8 Autoimmune Eye Diseases
Chapter Outline
Immune Privilege
Autoimmune Diseases of the Cornea and Conjunctiva
Autoimmune Diseases of the Uvea
Autoimmune Retinal Diseases
Ancillary Structures
Sources of Additional Information
Chapter 9 Autoimmune Reproductive Diseases
Chapter Outline
Autoimmunity in Males
Autoimmunity in Females
Autoallergy
Immune Contraception
Production-Enhancing Vaccines
Sources of Additional Information
Chapter 10 Autoimmune Skin Diseases
Chapter Outline
Blistering Diseases
Pemphigus Group
Pemphigoid Group
Melanocyte Diseases
Hair Follicle Diseases
Other Immune-Mediated Diseases
Sources of Additional Information
Chapter 11 Autoimmune Blood Diseases
Chapter Outline
Immune-Mediated Hemolytic Anemias
Immune-Mediated Thrombocytopenia
Antiphospholipid Syndrome
Immune-Mediated Lymphopenia
Immune-Mediated Neutropenia
Immune-Mediated Hemophagocytic Syndrome
Sources of Additional Information
Chapter 12 Autoimmune Muscle Diseases
Chapter Outline
Polymyositis
Autoimmune Heart Failure
Neuromuscular Junction Disorders
Sources of Additional Information
Chapter 13 Autoimmune and Immune-Mediated Liver and Kidney Diseases
Chapter Outline
Autoimmune Liver Diseases
Autoimmune Kidney Diseases
Immune Complex–Mediated Glomerulopathies
Sources of Additional Information
Chapter 14 Autoinflammatory Diseases
Chapter Outline
Autoinflammatory Diseases
Canine IgG4-Related Diseases
Sources of Additional Information
Chapter 15 Systemic Lupus Erythematosus
Chapter Outline
Predisposing Factors
Pathogenesis
Canine Systemic Lupus
Lupus-Related Skin Diseases
Nailbed Diseases
Sources of Additional Information
Chapter 16 Rheumatoid Arthritis
Chapter Outline
Rheumatoid Arthritis
Pathogenesis
Canine Rheumatoid Arthritis
Feline Erosive Polyarthritis
Sources of Additional Information
Chapter 17 Seronegative Nonerosive Arthropathies
Chapter Outline
Reactive Polyarthritis
Other Inflammatory Arthritides
Sources of Additional Information
Chapter 18 Immune-Mediated Vascular Disease
Chapter Outline
Arteritis
Small Blood Vessel Diseases
Sources of Additional Information
Chapter 19 Immune-Mediated Enteropathies
Chapter Outline
Genetic Predispositions
Intestinal Immune Tolerance
Loss of Food Tolerance
Canine Inflammatory Bowel Disease
Equine Inflammatory Bowel Disease
Sources of Additional Information
Chapter 20 Diagnostic Tests for Autoimmune Diseases
Chapter Outline
Primary Binding Tests
Secondary Binding Tests
Sources of Additional Information
Chapter 21 The Treatment of Immune-Mediated Diseases
Chapter Outline
Glucocorticosteroids
Calcineurin Inhibitors
Phosphodiesterase Inhibitors
Antimetabolites
Antiinflammatory Drugs
Sources of Additional Information
Chapter 22 Experimental Autoimmune Disease Models
Chapter Outline
Endocrine Diseases
Neurologic Diseases
Eye Diseases
Reproductive Diseases
Skin Diseases
Blood Diseases
Muscle Diseases
Liver Diseases
Systemic Lupus Erythematosus
Autoimmune Arthritis
Immune-Mediated Vasculitis
Inflammatory Intestinal Diseases
Sources of Additional Information
Index

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Ian R Tizard