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Asymmetric Synthesis V1
- 1st Edition - November 12, 2012
- Editor: James Morrison
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 3 3 6 8 3 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 6 0 0 0 - 1
Asymmetric Synthesis, Volume 1: Analytical Methods covers the major analytical methods used to determine enantiomeric ratios. This volume contains chapters that discuss the… Read more
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Request a sales quoteAsymmetric Synthesis, Volume 1: Analytical Methods covers the major analytical methods used to determine enantiomeric ratios. This volume contains chapters that discuss the methods used to obtain chiral compounds and shows how to evaluate the chiral efficiency of an asymmetric synthesis. Analytical methods such as polarimetry, competitive reaction methods, isotope dilution, gas and liquid chromatography, and nuclear magnetic resonance methods are also discussed. Chemists and researchers in the field of pharmaceutical will find the book very useful.
Contributors
Preface
1. A Summary of Ways to Obtain Optically Active Compounds
I. Introduction
II. Obtaining Chiral Compounds by the FRN Method
III. Isolating Chiral Compounds from Natural Sources
IV. Resolution of Racemic Modifications by the Physical Separation of Intermediate Diastereomers
V. Asymmetric Transformations
VI. Kinetic Resolution
VII. Asymmetric Synthesis
References
2. Polarimetry
I. Introduction
II. Instrumentation
III. Advantages of Optical Rotation Measurements
IV. Requirements for Precision of Data
References
3. Competitive Reaction Methods for the Determination of Maximum Specific Rotations
I. Introduction
II. Principles of Kinetic Resolution
III. Calculation of the Specific Rotation of an Enantiomer by Means of a Method Using Asymmetric Destruction of the Corresponding Racemic Mixture
IV. Calculation of the Specific Rotation of an Enantiomer by Means of a Method Using Two Reciprocal Kinetic Resolutions
V. Conclusion
References
4. Isotope-Dilution Techniques
I. Introduction
II. History
III. Theory
IV. Errors
V. Examples
References
5. Gas Chromatographic Methods
I. Introduction
II. Direct Resolution of Derivatized Enantiomers on Chiral Stationary Phases by Gas Chromatography
III. Direct Resolution of Underivatized Enantiomers on Metal-Containing Chiral Stationary Phases by Complexation Gas Chromatography
IV. Precision of Analysis and Practical Considerations
V. Conclusions
References
6. Separation of Enantiomers by Liquid Chromatographic Methods
I. Introduction and Background
II. General Considerations
III. Indirect Resolutions
IV. Direct Resolutions
V. Conclusions
References
7. Nuclear Magnetic Resonance Analysis Using Chiral Derivatives
I. Introduction
II. Application of Chemical Shift Nonequivalence
III. Application of Induced Chemical Shift Nonequivalence
References
8. Nuclear Magnetic Resonance Analysis Using Chiral Solvating Agents
I. Introduction
II. Principles
III. Chiral Solvating Agents, Solutes, and Association Interactions
IV. Practical Experimental Considerations
V. Comparison with the Chiral Lanthanide Shift Reagent Method
VI. Conclusions
References
9. Nuclear Magnetic Resonance Analysis Using Chiral Shift Reagents
I. Introduction
II. General Features of Shift Reagents
III. Structural Isomerism in Chiral Shift Reagents
IV. Variations in Structure
V. Mechanism of Action
VI. Uses of Chiral Shift Reagents
VII. Experimental Procedures
References
Index
- No. of pages: 216
- Language: English
- Edition: 1
- Published: November 12, 2012
- Imprint: Academic Press
- Paperback ISBN: 9780124336834
- eBook ISBN: 9780323160001