Asthma and COPD Overlap: An Update, An Issue of Immunology and Allergy Clinics of North America

Cover image

Title page

Table of Contents

Copyright

Contributors

Forthcoming Issues

Preface

When Asthma and Chronic Obstructive Pulmonary Disease Overlap; Current Knowledge and Unmet Needs

Key points

Defining asthma-chronic obstructive pulmonary disease overlap

Molecular and pathophysiological mechanisms of asthma-chronic obstructive pulmonary disease overlap

Epidemiology of asthma-chronic obstructive pulmonary disease overlap

Early features of chronic obstructive pulmonary disease in smokers with asthma

Genetic determinants of obstructive airway diseases

Lung physiology in asthma-chronic obstructive pulmonary disease overlap

Imaging in asthma-chronic obstructive pulmonary disease overlap

The role of allergy and environmental exposures in asthma and chronic obstructive pulmonary disease overlap

The role of smoking in asthma-chronic obstructive pulmonary disease overlap

Clinical assessment and utility of biomarkers in asthma-chronic obstructive pulmonary disease overlap

Phenotypes of asthma-chronic obstructive pulmonary disease overlap (including age and gender differences)

Summary

Defining Asthma–Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

Is asthma–chronic obstructive pulmonary disease overlap a specific entity?

Relevance of defining asthma–chronic obstructive pulmonary disease overlap

Current definitions and diagnosis of asthma and chronic obstructive pulmonary disease

The complexity of defining asthma–chronic obstructive pulmonary disease overlap

Proposed definitions for asthma–chronic obstructive pulmonary disease overlap

Future strategies

Summary

Clinics care points

Disclosure

Pathophysiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

Overview of the pathophysiology of asthma

Overview of the pathophysiology of chronic obstructive pulmonary disease

Pathophysiology of asthma-chronic obstructive pulmonary disease overlap

Discussion

Summary

Clinics care points

Epidemiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

Is asthma with fixed airflow obstruction asthma-chronic obstructive pulmonary disease overlap?

Prevalence of asthma-chronic obstructive pulmonary disease overlap

The prevalence of asthma-chronic obstructive pulmonary disease overlap across different criteria in the same population

Asthma-chronic obstructive pulmonary disease overlap in persons with known obstructive disease (asthma or chronic obstructive pulmonary disease overlap)

Asthma-chronic obstructive pulmonary disease overlap in persons with known asthma

Asthma-chronic obstructive pulmonary disease overlap in persons with known chronic obstructive pulmonary disease overlap

Asthma-chronic obstructive pulmonary disease overlap in general population

Regional variation in asthma-chronic obstructive pulmonary disease overlap prevalence

Asthma-chronic obstructive pulmonary disease overlap and demographic variables

Variation in asthma-chronic obstructive pulmonary disease overlap prevalence with exposure

Asthma-chronic obstructive pulmonary disease overlap and comorbidity

Asthma-chronic obstructive pulmonary disease overlap and lung function decline

Morbidity and mortality

Summary

Clinics care points

Supplementary data

Early Features of Chronic Obstructive Pulmonary Disease in Patients with Asthma: Is there ACO before ACO?

Key points

Introduction

Definitions of asthma and chronic obstructive pulmonary disease –what about asthma–chronic obstructive pulmonary disease overlap?

Could There Be Asthma–Chronic Obstructive Pulmonary Disease Overlap Without Irreversible Component of Airway Obstruction?

Should We only Care About ”Treatable Treats”?

Etiology of obstructive airway diseases

Asthma–Chronic Obstructive Pulmonary Disease Overlap in Young Patients with Asthma and in the Elderly

So, is there ACO before ACO?

The need for further research

Summary

Clinics care points

Genetic Determinants in Airways Obstructive Diseases: The Case of Asthma Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

Genome-wide association studies of asthma, chronic obstructive pulmonary disease, and their overlap

Other omics techniques in asthma–chronic obstructive pulmonary disease overlap

Summary

Clinics care points

The Physiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

Discussion

Summary

Clinics care points

Asthma-Chronic Obstructive Pulmonary Disease Overlap: The Role for Allergy

Key points

Introduction

Definition and diagnosis

The role of allergy in asthma-chronic obstructive pulmonary disease overlap

Asthma-chronic obstructive pulmonary disease overlap cellular and molecular mechanisms

Current treatments of asthma-chronic obstructive pulmonary disease overlap

Future therapeutic strategies in asthma-chronic obstructive pulmonary disease overlap

Clinics care points

Imaging in Asthma-Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

Discussion

Future directions

Summary

Clinics care points

Disclosure

The Role of Smoking in Asthma and Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

Prevalence and health burden of cigarette smoking in asthma–chronic obstructive pulmonary disease overlap

Cigarette smoking and diagnostic criteria for asthma–chronic obstructive pulmonary disease overlap

Cigarette smoking and other risk factors for asthma–chronic obstructive pulmonary disease overlap

Clinical outcomes in smoking-related asthma–chronic obstructive pulmonary disease overlap

Pathogenesis of smoking-related asthma–chronic obstructive pulmonary disease overlap

Inflammatory biomarkers in smoking-related asthma–chronic obstructive pulmonary disease overlap

Management

Summary

Clinics care points

Clinical Assessment and Utility of Biomarkers in Asthma-Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

Asthma-chronic obstructive pulmonary disease overlap: a term derived from Oslerian diagnostic label

Asthma-chronic obstructive pulmonary disease overlap: descriptive term with no widely accepted definition

Asthma-chronic obstructive pulmonary disease overlap: clinical features

Asthma-chronic obstructive pulmonary disease overlap: heterogeneity and clinical phenotypes

Asthma-chronic obstructive pulmonary disease overlap: any objective labels or biomarkers?

Summary

Clinics care points

Conflicts of interest

Phenotypes of Asthma–Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

What is a phenotype?

Defining asthma–chronic obstructive pulmonary disease overlap

Physiologic and morphologic differences between asthma–chronic obstructive pulmonary disease overlap and chronic obstructive pulmonary disease

Other biomarkers helpful in phenotyping asthma–chronic obstructive pulmonary disease overlap

Composite determinants of asthma–chronic obstructive pulmonary disease overlap phenotypes

Proposed clinical phenotypes

Role of phenotypes in the management of asthma–chronic obstructive pulmonary disease overlap

Future directions

Summary

Clinics care points

Pharmacologic Management Strategies of Asthma-Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

Discussion

Summary

Clinics care points

Novel Therapeutic Strategies in Asthma-Chronic Obstructive Pulmonary Disease Overlap

Key points

Introduction

Anti-immunoglobulin E

Anti-interleukin-5/5R

Targeting interleukin-4/13

Others

Summary

Clinics care points

Disclosure

Unmet Needs and the Future of Asthma-Chronic Pulmonary Obstructive Disease Overlap

Key points

Introduction

Summary

Clinics care points

Disclosure