Applications of Viruses for Cancer Therapy

Table of Contents

Cover image

Contributors

Chapter One Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes

1 Introduction

2 Viral Vectors for Cancer Gene Therapy

3 Adenoviruses as Vectors for Cancer Gene Therapy

4 Cancer Terminator Viruses: Efficacious Reagents for Cancer Gene Therapy

5 Approaches Enhancing Therapeutic Outcomes

6 Conclusions and Future Directions

Chapter Two Adenovirus Strategies for Tissue-Specific Targeting

1 Introduction

2 Ad Biology

3 Ad Capsid Structure

4 Ad Entry Biology

5 Transductional Targeting of Ad Vectors

6 Ad Transductional Targeting: Adapter-Based Strategies

7 FAB Antibody Adapters

8 Recombinant Fusion Adapters

9 Alternative Adapter Binding Locales

10 Adapters Utilizing Genetically Modified Ad Capsid

11 Ad Secretion of Adapter

12 Ad Transductional Targeting: Genetically Incorporated Strategies

13 Chimeric Ad

14 Peptide-Targeted Ad

15 “Knob-less”-Targeted Ad

16 Alternative Capsid Locations

17 Novel Transductional Strategies

18 Ad Targeting: Recent Clinical Developments

19 Concluding Remarks

Chapter Three Syrian Hamster as an Animal Model to Study Oncolytic Adenoviruses and to Evaluate the Efficacy of Antiviral Compounds

1 Introduction

2 Existing Animal Models

3 The Syrian Hamster Model

Chapter Four Design of Improved Oncolytic Adenoviruses

1 Introduction

2 Oncolytic Adenovirus Tumor Targeting

3 The Stroma Barrier to Oncolytic Adenovirus Spread

4 Antiadenovirus and Antitumor Immunity in the Outcome of Virotherapy

Chapter Five The Development of Transcription-Regulated Adenoviral Vectors with High Cancer-Selective Imaging Capabilities

1 Introduction

2 Preclinical Molecular Imaging Modalities

3 Cancer-Targeted Adenoviral Vector Gene Delivery

4 Transcriptional Amplification Strategies

5 Specific Applications

6 Concluding Remarks

Chapter Six Adenovirus-Based Immunotherapy of Cancer: Promises to Keep

1 Introduction: Promises to Keep

2 AdVs as Vaccine Vehicles

3 Optimizing AdVs for Clinical Translation

4 Ad-Based Tumor Immunotherapy Approaches: Vaccination and Beyond

5 Preclinical Models to Test Ad Cancer Vaccines

6 Next-Generation Ad Vaccines Against Cancer: The Way Forward

7 Concluding Remarks: Miles to Go

Chapter Seven Cancer Treatment with Gene Therapy and Radiation Therapy

1 Introduction

2 Molecular Mechanisms of Tumor Response to Radiation Therapy

3 Gene Transfer Systems

4 Radiation-Responsive Promoters

5 Therapeutic Transgenes

6 Molecular Chemotherapy and Radiation Therapy

7 Conclusion

Chapter Eight Oncolytic Adenoviruses for Cancer Immunotherapy

1 Introduction

2 Adenoviruses as Therapeutic Agents Against Cancer

3 Immune Recognition of Adenoviruses

4 Oncolytic Adenoviruses as Immunotherapeutic Agents

5 Final Remarks

Index