Applications of Nanotechnology in Drug Discovery and Delivery
- 1st Edition - August 17, 2022
- Editors: Chukwuebuka Egbuna, Mihnea-Alexandru Găman, Jaison Jeevanandam
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 4 0 8 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 9 3 1 - 8
Applications of Nanotechnology in Drug Discovery and Delivery, in the Drug Discovery Update series, presents complete coverage of the application of nanotechnology in the discovery… Read more
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Request a sales quoteApplications of Nanotechnology in Drug Discovery and Delivery, in the Drug Discovery Update series, presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials.
This book brings together a global team of experts, making it an essential resource for researchers, drug developers, medicinal chemists, toxicologists and analytical chemists.
- Serves as a guide to drug developers working in pharma, biotech and academia, bringing together the latest research on the topic
- Presents recent information on the use of nanomaterials for the development of drugs using engineered nanocarriers to target specific delivery
- Features a global team of contributing experts who discuss nanotechnology applications in drug discovery as well as safety issues and challenges
Researchers in organic and medicinal chemistry including drug developers, medicinal chemists, toxicologists, and analytical chemists
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Part 1: Fundamentals, Trends and Advances in Nanotechnology
- Chapter 1. Roles of nanoparticles in drug discovery and delivery
- Abstract
- Chapter Outline
- 1.1 Introduction
- 1.2 Types of nanoparticles
- 1.3 Application of nanoparticles
- 1.4 Summary and conclusion
- References
- Chapter 2. Nanoencapsulation of nutraceuticals and dietary supplements for effective delivery
- Abstract
- Chapter Outline
- 2.1 Introduction
- 2.2 Nutraceuticals
- 2.3 Nanoencapsulation of nutraceuticals and dietary supplements
- 2.4 Nanoencapsulation techniques for nutraceuticals
- 2.5 Encapsulated nutraceuticals for drug delivery
- 2.6 Conclusion
- Abbreviations
- References
- Chapter 3. Nanoformulation of antioxidant supplements
- Abstract
- Chapter Outline
- 3.1 Introduction
- 3.2 Nanoformulations methods
- 3.3 Nanoformulations for antioxidants
- 3.4 Antioxidants in nanomedicine
- 3.5 Advantages and disadvantages of nanofomulation of antioxidant supplements
- 3.6 Future perspective and conclusion
- Abbreviations
- References
- Chapter 4. Nanophytomedicines: nature to medicines
- Abstract
- Chapter Outline
- 4.1 Introduction
- 4.2 Nanophytomedicines
- 4.3 Therapeutic potentials of nanophytomedicine
- 4.4 Nanophytomedicines with improved target binding ability
- 4.5 Nanophytomedicines and their oral bioavailability
- 4.6 Nanophytomedicine with improved safety
- 4.7 Toxicity of nanophytomedicine
- 4.8 Regulatory aspects and ethical issues associated with nanophytomedicine
- 4.9 Challenges encountered in nanophytomedicine
- 4.10 Current progress and future prospects
- 4.11 Conclusion
- References
- Chapter 5. Characterization of nanoparticles: methods and techniques
- Abstract
- Chapter Outline
- 5.1 Introduction
- 5.2 Differential scanning calorimetry
- 5.3 Fourier transform infrared spectroscopy
- 5.4 Scanning electron microscopy
- 5.5 Transmission electron microscopy
- 5.6 X-Ray diffraction
- 5.7 Encapsulation efficiency, drug-loading capacity, and percentage of recovery
- 5.8 Topical nanoparticle strategies
- 5.9 Drug release studies of nanoparticles
- 5.10 Solubility of nanoparticles
- 5.11 Toxicity effects of nanoparticles
- 5.12 Stability enhancement of nanoparticles
- 5.13 Future projection and conclusion
- References
- Part 2: Nanopharmaceutical Applications In Clinical Practice
- Chapter 6. Applications of nanotechnology in pharmaceutical products
- Abstract
- Chapter Outline
- 6.1 Introduction
- 6.2 Comparison of traditional and nanodrug delivery
- 6.3 Pharmaceutical products through nanotechnology
- 6.4 Applications of nanotechnology in pharmaceutical processes
- 6.5 Challenges in nanotechnology-based drug delivery system
- 6.6 Conclusion and future perspectives
- References
- Chapter 7. Advances in nanotechnology for drug discovery and design
- Abstract
- Chapter Outline
- 7.1 Introduction
- 7.2 Nanomaterials, nanotechnology, and nanobiotechnology
- 7.3 Role of nanotechnology and nanobiotechnology in biomedicine
- 7.4 Hurdles and challenges
- 7.5 Future perspectives
- 7.6 Summary and conclusion
- References
- Further reading
- Chapter 8. Nanomedicine for diabetes mellitus management
- Abstract
- Chapter Outline
- 8.1 Introduction
- 8.2 Type 1 diabetes mellitus and nanomedicine
- 8.3 Type 2 diabetes mellitus and nanomedicine
- 8.4 Insulin delivery and nanotechnology
- 8.5 Nanopumps
- 8.6 Insulin delivery via inhalation
- 8.7 Transplanted pancreatic islets nanoencapsulation
- 8.8 Biological microelectromechanical systems for insulin delivery
- 8.9 Nanotechnology in noninsulin remedy
- 8.10 Nanotechnology applications in the management of diabetes-related complications
- 8.11 Advantages of using nanotechnology in diabetes mellitus management
- 8.12 Limitations in using nanotechnology in diabetes mellitus management
- 8.13 Conclusion
- References
- Chapter 9. Nanotechnological application of peptide- and protein-based therapeutics
- Abstract
- Chapter Outline
- 9.1 Introduction
- 9.2 Benefits of peptide and protein therapeutics in biomedicine
- 9.3 Challenges with peptide- and protein-based therapeutics
- 9.4 Excipients used in synthesis of protein and peptide nanoparticles
- 9.5 Therapeutic and diagnostic applications of protein-based therapeutics nanomaterials
- 9.6 Improving stability using protein-based therapeutics nanoparticles
- 9.7 Evaluation parameters and formulation techniques for protein/peptide nanoparticles
- 9.8 Biomedical applications of nanoparticles of proteins and peptides
- 9.9 Concerns about peptide- and protein-based nanoparticles
- 9.10 Future prospects
- 9.11 Conclusion
- Abbreviations
- References
- Chapter 10. Nanodrug delivery systems in cancer therapy
- Abstract
- Chapter Outline
- 10.1 Introduction
- 10.2 Currently available conventional cancer therapy
- 10.3 Drug delivery systems
- 10.4 Drug carriers
- 10.5 Protein nanoparticles
- 10.6 Anticancer nanoparticle drugs
- 10.7 Application of nanodrug delivery systems
- 10.8 Drawbacks of using nanodrug delivery
- 10.9 Conclusion and future perspectives
- References
- Chapter 11. Nanotechnology interventions in neuroscience: current perspectives and strategies
- Abstract
- Chapter Outline
- 11.1 Introduction
- 11.2 Nanotechnology in neuroimaging
- 11.3 Nanotechnology in neurodiagnostic
- 11.4 Nanotechnology in neurological devices
- 11.5 Nanotechnology-based therapeutic interventions for neural disorders
- 11.6 Future perspectives
- 11.7 Conclusions
- References
- Chapter 12. Nanotechnology application for effective delivery of antimalarial drugs
- Abstract
- Chapter Outline
- 12.1 Introduction
- 12.2 Nanotechnology approaches for antimalarial
- 12.3 Nano-based drug preparation materials
- 12.4 Nano-based drug delivery for malarial treatment
- 12.5 Nanocarriers for antimalarial drug
- 12.6 Nanocapsules
- 12.7 Challenges of nanotechnology for antimalarial drugs
- 12.8 Conclusion and future prospects
- Abbreviations
- References
- Chapter 13. Applications of nanotechnology in lung cancer
- Abstract
- Chapter Outline
- 13.1 Introduction
- 13.2 Classification of nanoparticles
- 13.3 Relationship between nanoparticles and drug delivery
- 13.4 Lung cancer
- 13.5 Nanotechnology application in targeting lung cancer
- 13.6 Advantages of nanoparticles for targeted drug delivery
- 13.7 Disadvantages of nanoparticles for targeted drug delivery
- 13.8 Conclusion
- References
- Part 3: Toxicology and Safety Issues
- Chapter 14. Toxicity of nanomaterials in drug delivery
- Abstract
- Chapter Outline
- 14.1 Introduction
- 14.2 Applications of nanomaterials in drug delivery: a brief overview
- 14.3 Cellular uptake and metabolomics of nanomaterials in a biological system
- 14.4 Toxicity of nanomaterials in biological systems: potential exposure routes
- 14.5 Potential mechanisms of nanomaterials toxicity in biological systems
- 14.6 Future perspective and conclusion
- References
- Chapter 15. In vitro and in vivo toxicity of metal nanoparticles and their drug delivery applications
- Abstract
- Chapter Outline
- 15.1 Introduction
- 15.2 Metal nanoparticles
- 15.3 In vitro toxic analysis of metal nanoparticles
- 15.4 In vivo toxic analysis of metal nanoparticles
- 15.5 Drug delivery applications of metal nanoparticles
- 15.6 Future perspective
- 15.7 Conclusion
- References
- Index
- No. of pages: 448
- Language: English
- Edition: 1
- Published: August 17, 2022
- Imprint: Elsevier
- Paperback ISBN: 9780128244081
- eBook ISBN: 9780323859318
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Chukwuebuka Egbuna
Chukwuebuka Egbuna (PhD) is a chartered chemist and academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and the Royal Society of Chemistry (RSC) (United Kingdom). Dr. Egbuna is the founder and editor of the Elsevier book series on Drug Discovery Update. The series includes books, monographs, and edited collections from all areas of drug discovery including emerging therapeutic claims for the treatment of diseases. He has published research articles in many international journals of repute and is ranked among the top 500 Nigerian scientists in SciVal/SCOPUS. He has edited more than 25 books with Elsevier, Springer, Wiley, and Taylor & Francis. His most recent book is the three volume Coronavirus Drug Discovery, published by Elsevier. Dr. Egbuna is the founder and the publishing director of IPS Intelligentsia Publishing Services.
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Mihnea-Alexandru Găman
Mihnea-Alexandru Găman received his MD at the Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Dr. Găman is currently specializing in clinical hematology at the Department of Hematology, Centre of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania. He has published more than 100 papers in international impact factor journals, as well as served as editor and author for international and national books/book chapters. In addition, Dr. Găman also serves as Scientific Editor, Associate Editor, Editorial Board Member and Peer-Reviewer for several international and national journals. His main fields of interest include hematology, molecular biology, oncology, internal medicine, medical education, fundamental sciences, and translational/interdisciplinary medicine.
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