Applications of Nanotechnology in Drug Discovery and Delivery

1st Edition - August 17, 2022
Editors: Chukwuebuka Egbuna, Mihnea-Alexandru Găman, Jaison Jeevanandam
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 4 0 8 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 3 1 - 8

Applications of Nanotechnology in Drug Discovery and Delivery, in the Drug Discovery Update series, presents complete coverage of the application of nanotechnology in the discovery… Read more

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Applications of Nanotechnology in Drug Discovery and Delivery, in the Drug Discovery Update series, presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials.

This book brings together a global team of experts, making it an essential resource for researchers, drug developers, medicinal chemists, toxicologists and analytical chemists.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Part 1: Fundamentals, Trends and Advances in Nanotechnology
Chapter 1. Roles of nanoparticles in drug discovery and delivery
Abstract
Chapter Outline
1.1 Introduction
1.2 Types of nanoparticles
1.3 Application of nanoparticles
1.4 Summary and conclusion
References
Chapter 2. Nanoencapsulation of nutraceuticals and dietary supplements for effective delivery
Abstract
Chapter Outline
2.1 Introduction
2.2 Nutraceuticals
2.3 Nanoencapsulation of nutraceuticals and dietary supplements
2.4 Nanoencapsulation techniques for nutraceuticals
2.5 Encapsulated nutraceuticals for drug delivery
2.6 Conclusion
Abbreviations
References
Chapter 3. Nanoformulation of antioxidant supplements
Abstract
Chapter Outline
3.1 Introduction
3.2 Nanoformulations methods
3.3 Nanoformulations for antioxidants
3.4 Antioxidants in nanomedicine
3.5 Advantages and disadvantages of nanofomulation of antioxidant supplements
3.6 Future perspective and conclusion
Abbreviations
References
Chapter 4. Nanophytomedicines: nature to medicines
Abstract
Chapter Outline
4.1 Introduction
4.2 Nanophytomedicines
4.3 Therapeutic potentials of nanophytomedicine
4.4 Nanophytomedicines with improved target binding ability
4.5 Nanophytomedicines and their oral bioavailability
4.6 Nanophytomedicine with improved safety
4.7 Toxicity of nanophytomedicine
4.8 Regulatory aspects and ethical issues associated with nanophytomedicine
4.9 Challenges encountered in nanophytomedicine
4.10 Current progress and future prospects
4.11 Conclusion
References
Chapter 5. Characterization of nanoparticles: methods and techniques
Abstract
Chapter Outline
5.1 Introduction
5.2 Differential scanning calorimetry
5.3 Fourier transform infrared spectroscopy
5.4 Scanning electron microscopy
5.5 Transmission electron microscopy
5.6 X-Ray diffraction
5.7 Encapsulation efficiency, drug-loading capacity, and percentage of recovery
5.8 Topical nanoparticle strategies
5.9 Drug release studies of nanoparticles
5.10 Solubility of nanoparticles
5.11 Toxicity effects of nanoparticles
5.12 Stability enhancement of nanoparticles
5.13 Future projection and conclusion
References
Part 2: Nanopharmaceutical Applications In Clinical Practice
Chapter 6. Applications of nanotechnology in pharmaceutical products
Abstract
Chapter Outline
6.1 Introduction
6.2 Comparison of traditional and nanodrug delivery
6.3 Pharmaceutical products through nanotechnology
6.4 Applications of nanotechnology in pharmaceutical processes
6.5 Challenges in nanotechnology-based drug delivery system
6.6 Conclusion and future perspectives
References
Chapter 7. Advances in nanotechnology for drug discovery and design
Abstract
Chapter Outline
7.1 Introduction
7.2 Nanomaterials, nanotechnology, and nanobiotechnology
7.3 Role of nanotechnology and nanobiotechnology in biomedicine
7.4 Hurdles and challenges
7.5 Future perspectives
7.6 Summary and conclusion
References
Further reading
Chapter 8. Nanomedicine for diabetes mellitus management
Abstract
Chapter Outline
8.1 Introduction
8.2 Type 1 diabetes mellitus and nanomedicine
8.3 Type 2 diabetes mellitus and nanomedicine
8.4 Insulin delivery and nanotechnology
8.5 Nanopumps
8.6 Insulin delivery via inhalation
8.7 Transplanted pancreatic islets nanoencapsulation
8.8 Biological microelectromechanical systems for insulin delivery
8.9 Nanotechnology in noninsulin remedy
8.10 Nanotechnology applications in the management of diabetes-related complications
8.11 Advantages of using nanotechnology in diabetes mellitus management
8.12 Limitations in using nanotechnology in diabetes mellitus management
8.13 Conclusion
References
Chapter 9. Nanotechnological application of peptide- and protein-based therapeutics
Abstract
Chapter Outline
9.1 Introduction
9.2 Benefits of peptide and protein therapeutics in biomedicine
9.3 Challenges with peptide- and protein-based therapeutics
9.4 Excipients used in synthesis of protein and peptide nanoparticles
9.5 Therapeutic and diagnostic applications of protein-based therapeutics nanomaterials
9.6 Improving stability using protein-based therapeutics nanoparticles
9.7 Evaluation parameters and formulation techniques for protein/peptide nanoparticles
9.8 Biomedical applications of nanoparticles of proteins and peptides
9.9 Concerns about peptide- and protein-based nanoparticles
9.10 Future prospects
9.11 Conclusion
Abbreviations
References
Chapter 10. Nanodrug delivery systems in cancer therapy
Abstract
Chapter Outline
10.1 Introduction
10.2 Currently available conventional cancer therapy
10.3 Drug delivery systems
10.4 Drug carriers
10.5 Protein nanoparticles
10.6 Anticancer nanoparticle drugs
10.7 Application of nanodrug delivery systems
10.8 Drawbacks of using nanodrug delivery
10.9 Conclusion and future perspectives
References
Chapter 11. Nanotechnology interventions in neuroscience: current perspectives and strategies
Abstract
Chapter Outline
11.1 Introduction
11.2 Nanotechnology in neuroimaging
11.3 Nanotechnology in neurodiagnostic
11.4 Nanotechnology in neurological devices
11.5 Nanotechnology-based therapeutic interventions for neural disorders
11.6 Future perspectives
11.7 Conclusions
References
Chapter 12. Nanotechnology application for effective delivery of antimalarial drugs
Abstract
Chapter Outline
12.1 Introduction
12.2 Nanotechnology approaches for antimalarial
12.3 Nano-based drug preparation materials
12.4 Nano-based drug delivery for malarial treatment
12.5 Nanocarriers for antimalarial drug
12.6 Nanocapsules
12.7 Challenges of nanotechnology for antimalarial drugs
12.8 Conclusion and future prospects
Abbreviations
References
Chapter 13. Applications of nanotechnology in lung cancer
Abstract
Chapter Outline
13.1 Introduction
13.2 Classification of nanoparticles
13.3 Relationship between nanoparticles and drug delivery
13.4 Lung cancer
13.5 Nanotechnology application in targeting lung cancer
13.6 Advantages of nanoparticles for targeted drug delivery
13.7 Disadvantages of nanoparticles for targeted drug delivery
13.8 Conclusion
References
Part 3: Toxicology and Safety Issues
Chapter 14. Toxicity of nanomaterials in drug delivery
Abstract
Chapter Outline
14.1 Introduction
14.2 Applications of nanomaterials in drug delivery: a brief overview
14.3 Cellular uptake and metabolomics of nanomaterials in a biological system
14.4 Toxicity of nanomaterials in biological systems: potential exposure routes
14.5 Potential mechanisms of nanomaterials toxicity in biological systems
14.6 Future perspective and conclusion
References
Chapter 15. In vitro and in vivo toxicity of metal nanoparticles and their drug delivery applications
Abstract
Chapter Outline
15.1 Introduction
15.2 Metal nanoparticles
15.3 In vitro toxic analysis of metal nanoparticles
15.4 In vivo toxic analysis of metal nanoparticles
15.5 Drug delivery applications of metal nanoparticles
15.6 Future perspective
15.7 Conclusion
References
Index

Chukwuebuka Egbuna

Chukwuebuka Egbuna (PhD) is a chartered chemist and academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and the Royal Society of Chemistry (RSC) (United Kingdom). Dr. Egbuna is the founder and editor of the Elsevier book series on Drug Discovery Update. The series includes books, monographs, and edited collections from all areas of drug discovery including emerging therapeutic claims for the treatment of diseases. He has published research articles in many international journals of repute and is ranked among the top 500 Nigerian scientists in SciVal/SCOPUS. He has edited more than 25 books with Elsevier, Springer, Wiley, and Taylor & Francis. His most recent book is the three volume Coronavirus Drug Discovery, published by Elsevier. Dr. Egbuna is the founder and the publishing director of IPS Intelligentsia Publishing Services.

Affiliations and expertise

Africa Centre of Excellence in Public Health and Toxicological Research, University of Port Harcourt, Nigeria

Mihnea-Alexandru Găman

Mihnea-Alexandru Găman received his MD at the Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Dr. Găman is currently specializing in clinical hematology at the Department of Hematology, Centre of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania. He has published more than 100 papers in international impact factor journals, as well as served as editor and author for international and national books/book chapters. In addition, Dr. Găman also serves as Scientific Editor, Associate Editor, Editorial Board Member and Peer-Reviewer for several international and national journals. His main fields of interest include hematology, molecular biology, oncology, internal medicine, medical education, fundamental sciences, and translational/interdisciplinary medicine.

Affiliations and expertise

Specialist, Clinical Haemotology, Department of Haemotology, Centre of Haemotology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania

Jaison Jeevanandam

Dr. Jaison Jeevanandam is currently working as a senior researcher in Centro De Quimica Da Madeira (CQM – Center for Chemistry), University of Madeira, Portugal. He obtained his Ph.D. in the Department of Chemical Engineering, Faculty of Engineering and Science from Curtin University, Malaysia. He has experience in nanoparticle synthesis, especially in the green synthesis using plant extracts, characterization, cytotoxic analysis of nanoparticles, and in vitro analysis in diabetic models. His current research focuses on the application of nanobiotechnology in the development of nanoformulations for drug delivery systems. He has won several awards, including ‘Best teacher award 2019’ from Academy of competitive exam and research training (ACERT, Chennai), India; Gold medal in 3rd World Invention Innovation Contest (WiC) in 2017 from Korea Invention News (South Korea); Special honor of invention award, 3rd World Invention Innovation Contest (WiC) in 2017 from Toronto International Society of Innovation & Advanced Skills (TISIAS) (Canada). Dr. Jaison has authored +50 articles. Further, Dr. Jaison serves as a journal editor for Bio-integration (China) and International Archives of Biomedical and Engineering Sciences (India), as well as an invited editor for special issue in applied sciences (MDPI), Frontiers in Bioengineering and Biotechnology (Research topic coordinator) and Frontiers in molecular biosciences; and reviewer for 10+ journals.

Affiliations and expertise

Senior Researcher, CQM - Centro De Quimica Da Madeira, MMRG, Universidade Da Madeira, Funchal, Madeira, Portugal

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Applications of Nanotechnology in Drug Discovery and Delivery

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Chukwuebuka Egbuna

Mihnea-Alexandru Găman

Jaison Jeevanandam