Applications in High Resolution Mass Spectrometry

Chapter 1. HRMS: Fundamentals and Basic Concepts

• 1.1. Introduction (To High-Resolution Mass Spectrometry)
• 1.2. Resolution and Mass Resolving Power
• 1.3. Accurate Mass Measurement: Exact Mass and Mass Defect
• 1.4. Mass Calibration in High-Resolution Mass Spectrometry
• 1.5. General Considerations

Chapter 2. HRMS: Hardware and Software

• 2.1. Introduction
• 2.2. Principles of High-Resolution Mass Spectrometry Analyzers
• 2.3. Time-of-Flight Mass Spectrometry: Instrument Configuration and Main Features
• 2.4. Orbitrap Analyzers: Instrument Configurations and Main Features
• 2.5. Acquisition Modes in High-Resolution Mass Spectrometry
• 2.6. Databases and the Internet Resources for High-Resolution Mass Spectrometry

Chapter 3. Analytical Strategies Used in HRMS

• 3.1. Introduction
• 3.2. Advantages of High-Resolution Mass Spectrometry in Pesticide Analysis
• 3.3. Data Analysis Workflows in High-Resolution Mass Spectrometry
• 3.4. Conclusions

Chapter 4. Current Legislation on Pesticides

• 4.1. Introduction
• 4.2. Pesticides
• 4.3. Legislation
• 4.4. Analytical Quality Control—Method Validation
• 4.5. Mass Spectrometry in Pesticide Residue Analysis

Chapter 5. Advanced Sample Preparation Techniques for Pesticide Residues Determination by HRMS Analysis

• 5.1. Introduction
• 5.2. Matrix Effects and the Influence of Coextracted Components
• 5.3. Sample Preparation Techniques for Pesticide Residue Determination by Chromatographic Techniques Coupled to High-Resolution Mass Spectrometry
• 5.4. Perspectives and Conclusions

Chapter 6. Applications of Liquid Chromatography Coupled With High-Resolution Mass Spectrometry for Pesticide Residue Analysis in Fruit and Vegetable Matrices

• 6.1. Introduction
• 6.2. Applications of Pesticide Residue Analysis in Fruit and Vegetable Samples by LC-HRMS
• 6.3. Optimized Sample Preparation and Chromatographic Conditions for Mass Analyzers
• 6.4. Analytical Method Validation
• 6.5. Accurate Measurement of Pesticide Residues in Fruit and Vegetable Samples
• 6.6. Evaluation of Pesticide Residues in Fruit and Vegetable Samples
• 6.7. Conclusion

Chapter 7. Application of HRMS in Pesticide Residue Analysis in Food From Animal Origin

• 7.1. Introduction
• 7.2. Instrumental Requirements
• 7.3. Analytical Procedures: Extraction and Chromatographic Conditions
• 7.4. Quantitative and Qualitative Applications
• 7.5. Differences Between Low-Resolution Mass Spectrometry and High-Resolution Mass Spectrometry Analytical Methods
• 7.6. Overview and Future Perspectives

Chapter 8. Recent Advances in HRMS Analysis of Pesticide Residues Using Atmospheric Pressure Gas Chromatography and Ion Mobility

• 8.1. Introduction
• 8.2. Atmospheric Pressure Gas Chromatography
• 8.3. Time-of-Flight Mass Spectrometry
• 8.4. Ion Mobility Separation
• 8.5. Summary and Conclusion

Chapter 9. Direct Analysis of Pesticides by Stand-Alone Mass Spectrometry: Flow Injection and Ambient Ionization

• 9.1. Introduction
• 9.2. Flow Injection Analysis
• 9.3. Ambient Mass Spectrometry
• 9.4. Final Remarks and Future Trends

Chapter 10. Identification of Pesticide Transformation Products in Food Applying High-Resolution Mass Spectrometry

• 10.1. Introduction
• 10.2. Experimental
• 10.3. Imidacloprid Metabolites in Plants
• 10.4. Imazalil Metabolites in Plants and Soil
• 10.5. Propiconazole Metabolites in Plants and Soil
• 10.6. Conclusions