Application of Gellan Gum as a Biomedical Polymer

1st Edition - May 21, 2024
Editors: Amit Kumar Nayak, Md Saquib Hasnain
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 8 1 5 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 7 2 4 3 - 7

Application of Gellan Gum as a Biomedical Polymer details key topics and fundamental aspects of gellan gum and its biomedical applications in drug delivery, proteins and peptid… Read more

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Application of Gellan Gum as a Biomedical Polymer details key topics and fundamental aspects of gellan gum and its biomedical applications in drug delivery, proteins and peptides delivery, cell delivery, tissue engineering, wound dressings and enzyme immobilizations in developing high quality products. Sections introduce gellan gum, its source, production and gelation mechanism, discuss biomedical materials, and provides ways it can be used for biomedical applications. The book also examines the used of gellan gum as pharmaceutical excipients for drug delivery. Future developments and challenges round out the book’s coverage.

With contributions for an international group of experts, this book is a useful reference for scientists, researchers and those in industry engaged in biomedical product development using natural polysaccharides.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. An overview of gellan gum sources, properties, and its targeted applications
Abstract
1.1 Introduction
1.2 Gellan gum: source and chemistry background
1.3 Gellan gum properties for diverse drug delivery applications
1.4 Gellan gum properties for wound dressing application
1.5 Gellan gum properties for cartilage and scaffold application
1.6 Gellan gum properties for dentistry application
1.7 Conclusion
Acknowledgment
Conflicts of interest
References
Chapter 2. Impact of environmental conditions on the preparation and functionality of gellan gum
Abstract
2.1 Effect of pH
2.2 Effect of temperature
2.3 Effect of types and concentration of ions
2.4 Effect of sugars
2.5 Gellan’s interactions with other biomolecules
2.6 Effect of degree of acylation
References
Chapter 3. Sol–gel behavior of gellan gum and its applications in biomedical industry
Abstract
3.1 Introduction
3.2 Determination of sol–gel transition of gellan gum
3.3 Sol–gel behavior of gellan gum
3.4 Biomedical applications
References
Chapter 4. Gelation mechanism of gellan gum for biomedical applications
Abstract
4.1 Introduction
4.2 Gelation mechanism
4.3 Applications of gellan gum in the biomedical area
4.4 Some reviews of research about gellan gum in biomedical applications
4.5 Conclusions
Acknowledgments
References
Section I: Biomedical materials
Chapter 5. Biomedical property of gellan gum
Abstract
5.1 Introduction
5.2 Discovery of gellan and structure
5.3 Physicochemical properties
5.4 Biomedical properties
5.5 Conclusions
References
Chapter 6. Gellan gum–based biomedical gels
Abstract
6.1 Introduction
6.2 Gellan gum–based gels
6.3 Biomedical applications
6.4 Concluding remarks
Acknowledgments
References
Chapter 7. Gellan gum–based hydrogels as useful biomedical material
Abstract
7.1 Introduction
7.2 Gellan gum hydrogels
7.3 Fabrication strategies for tuning physicochemical properties
7.4 Biomedical applications of gellan gum hydrogels
7.5 Conclusion
References
Chapter 8. Gellan gum microspheres and their applications in the biomedical industry
Abstract
8.1 Introduction
8.2 Gellan gum applications
8.3 Methodologies for the microspheres production
8.4 Gellan gum–based microspheres applications
8.5 Conclusions and future perspectives
Acknowledgments
References
Chapter 9. Gellan gum–based nanocomposite hydrogels
Abstract
9.1 Introduction
9.2 Synthesis methods and structures of gellan gum hydrogels
9.3 Modifications of gellan gum structure
9.4 Medical application of gellan gum nanocomposites
9.5 Conclusion
References
Chapter 10. Gellan gum based nanosystems for biomedical applications
Abstract
10.1 Introduction
10.2 Gellan gum: source, chemistry, and composition
10.3 Modification of gellan gum for nanosystem designing
10.4 Different nanosystems based on gellan gum
10.5 Applications of gellan gum nanosystems
10.6 Conclusion
References
Chapter 11. Crosslinked gellan gum for biomedical applications
Abstract
11.1 Introduction
11.2 Crosslinked gellan gum in drug delivery
11.3 Crosslinked gellan gum in wound healing
11.4 Conclusion
Acknowledgments
References
Section II: Biomedical applications
Chapter 12. Gellan gum–based wound dressings
Abstract
12.1 Introduction
12.2 Classification of wound dressings
12.3 Properties of gellan gum
12.4 Uses of gellan gum in wound dressing formulations and their characteristics
12.5 Conclusion
References
Chapter 13. Probiotic encapsulation and delivery using gellan gum
Abstract
13.1 Introduction
13.2 Probiotic encapsulation and delivery using gellan gum
13.3 What do we know to date about probiotic encapsulation with gellan gum?
13.4 Conclusion
Acknowledgments
Conflict of interest
References
Chapter 14. Protein and peptide delivery using gellan gum
Abstract
14.1 Introduction
14.2 Drug deliverance systems as carriers for biological molecules
14.3 Peptides with modifiable construction
14.4 Physical and chemical features of protein-based medications
14.5 Biologic barriers
14.6 Formulization strategies for noninvasive protein medication deliverance
14.7 Cons and restrictions of protein nanoparticles
14.8 Various carriers are used for the transfer of these therapeutic proteins into the body
14.9 Gellan gum in a medication deliverance system
14.10 Conclusion
References
Chapter 15. Uses of gellan gum for nutrient delivery
Abstract
15.1 Introduction
15.2 Gellan gum
15.3 Gellan gum in macronutrients delivery
15.4 Gellan gum in micronutrients delivery
Acknowledgments
References
Chapter 16. Uses of gellan gum for growth factor delivery
Abstract
16.1 Introduction
16.2 Gellan gum hydrogels stacked with the nerve growth factor
16.3 Gellan metacrylic gum with plaque lysis
16.4 Gellan gum-based physical hydrogels correlating BMP-2 as platforms for bone formation
16.5 The application of gellan gum hydrogels for the delivery of growth factor microspheres and the transport of stem cells to regenerate cartilage
16.6 Combining exclusive biopolymers in a center/shell style using a 3D plotting system
References
Chapter 17. Immunomodulatory functions and properties of gellan gum–based formulation
Abstract
17.1 Introduction
17.2 Application of gellan gum
17.3 The effect of gellan gum on immune response
17.4 Clinical trial using gellan gum
17.5 Summary
References
Chapter 18. Application of gellan gum in tropical medicine
Abstract
18.1 Introduction
18.2 How can gellan gum be applied in tropical medicine?
18.3 Application of gellan gum in tropical medicine
18.4 Conclusion
Conflict of interest
References
Section III: Pharmaceutical excipients
Chapter 19. Gellan gum–based microparticles and beads for sustained drug delivery
Abstract
19.1 Introduction
19.2 Sources
19.3 Physicochemical properties
19.4 Advantages of using gellan gum in drug delivery
19.5 Methods of formulation of gellan gum microparticles
19.6 Delivery of therapeutics from gellan gum microparticles
19.7 Gellan gum microparticles–based drug delivery systems for different modes
19.8 Delivery of proteins from gellan gum microparticles
19.9 Conclusion and perspectives
References
Chapter 20. Nanoformulations of gellan gum for improved drug delivery
Abstract
20.1 Introduction
20.2 General properties of gellan gum
20.3 Properties
20.4 Gellan gum in drug delivery
20.5 Drug-releasing potential of gellan gum–based nanoformulations
20.6 Conclusion
References
Chapter 21. Gellan gum–based in situ gels for drug delivery
Abstract
21.1 Introduction
21.2 Sources and structure
21.3 Properties
21.4 Gellan gum hydrogels in drug delivery
21.5 Conclusions
Acknowledgment
References
Chapter 22. Gellan gum–based ocular formulations
Abstract
22.1 Introduction
22.2 Pharmaceutical formulations of gellan gum
22.3 Conclusion
References
Chapter 23. Gellan gum-based dermatological formulations
Abstract
23.1 Introduction
23.2 Dermatological sciences
23.3 Gellan gum-based dermatological formulations
23.4 Conclusion and future perspectives
Acknowledgments
Conflict of interest
References
Chapter 24. Gellan gum derivatives for the preparation of drug delivery systems
Abstract
24.1 Introduction
24.2 Functional derivatives of gellan
24.3 Types of polymer systems based on gellan derivatives for drug encapsulation
24.4 Applications of systems based on gellan derivatives in drug delivery
24.5 Conclusions
References
Chapter 25. Gellan gum–based interpenetrating polymer networks for sustained-release drug delivery
Abstract
25.1 Introduction
25.2 Production, isolation, and purification of gellan gum
25.3 Interpenetrated polymer networks
25.4 Gellan gum as biopolymer in drug delivery
25.5 Sustained drug delivery through gellan gum–made interpenetrated polymer network–based systems
25.6 Conclusion
References
Chapter 26. Gellan gum as a drug delivery system: reproductive and developmental toxicity, and its potential role in the management of female reproductive disorders
Abstract
26.1 Introduction
26.2 Role of gellan gum in drug delivery
26.3 Potential role of gellan gum in the management of reproductive disorders
26.4 Reproductive and development toxicity of gellan gum
26.5 Conclusions and future perspective
References
Index

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 13 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 100 publications in various high impact peer-reviewed journals, more than 100 book chapters and 30 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record. He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Palamau Institute of Pharmacy, Daltonganj, Jharkhand, India

Life sciences

Physical sciences & Engineering

Social sciences & Humanities

Health