Antiplatelet and Anticoagulation Therapy in Cardiovascular and Pulmonary Embolism Transcatheter Interventions, An Issue of Interventional Cardiology Clinics

1st Edition, Volume 13-4 - September 12, 2024
Editor: Luis Ortega Paz
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 2 9 6 7 2 - 7
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 9 6 7 3 - 4

In this issue of Interventional Cardiology Clinics, guest editor Dr. Luis Ortega Paz brings his considerable expertise to the topic of Antiplatelet and Anticoagulation Therapy i… Read more

Antiplatelet and Anticoagulation Therapy in Cardiovascular and Pulmonary Embolism Transcatheter Interventions, An Issue of Interventional Cardiology Clinics

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In this issue of Interventional Cardiology Clinics, guest editor Dr. Luis Ortega Paz brings his considerable expertise to the topic of Antiplatelet and Anticoagulation Therapy in Cardiovascular and Pulmonary Embolism Transcatheter Interventions. Top experts in the field discuss regulation of platelet activation and coagulation; genetic determinants of P2Y12 inhibitors and clinical implications; switching P2Y12 receptor inhibiting therapies; high bleeding risk in patients undergoing coronary and structural heart interventions; and much more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Regulation of Platelet Activation and Coagulation: Current Concepts, Novel Targets, and Therapies
Key points
Individual risk assessment of bleeding versus thrombosis, need for new concepts and novel targets
Role of personalized antithrombotic therapy
Current concepts of antiplatelet therapy
Current concepts of anticoagulation
Summary and future perspectives
Clinics care points
Genetic Determinants of Response to P2Y12 Inhibitors and Clinical Implications
Key points
Introduction
Pharmacology of P2Y12 inhibitors
Genetic determinants of response to P2Y12 inhibitors
Therapeutic approaches based on CYP2C19 genotype
Clinical trial data with CYP2C19-guided antiplatelet therapy
Guidelines for CYP2C19-guided antiplatelet therapy
Clinical implementation of CYP2C19 genotyping
Summary and future perspectives
Clinics care points
High Bleeding Risk in Patients Undergoing Coronary and Structural Heart Interventions
Key points
Introduction
Incidence and clinical impact of bleeding
High bleeding risk definition and risk stratification
Summary
Clinics care points
Antithrombotic Therapy in Patients with Chronic Coronary Syndromes
Key points
Introduction
Chronic coronary syndrome without baseline indication to oral anticoagulation
Chronic coronary syndrome with baseline indication to oral anticoagulation
Chronic coronary syndrome and percutaneous coronary intervention without baseline indication to anticoagulation
Chronic coronary syndrome and percutaneous coronary intervention with baseline indication to anticoagulation
Summary
Clinics care points
Antithrombotic Therapy in Acute Coronary Syndrome
Key points
Introduction
Antiplatelet agents
Anticoagulants
Current standard recommendations for antithrombotic therapy in acute coronary syndrome
Individualized approach to antithrombotic therapy
Summary and future directions
Antithrombotic Therapy in Patients with Complex Percutaneous Coronary Intervention and Cardiogenic Shock
Key points
Introduction
Antithrombotic therapy in complex percutaneous coronary intervention
Antithrombotic therapy in cardiogenic SHOCK
Summary
Clinics care points
Antiplatelet Therapy in Patients Requiring Oral Anticoagulation and Undergoing Percutaneous Coronary Intervention
Key points
Introduction
Pathophysiological substrate
Evidence from randomized trials
Evidence from major national and international registries
Evidence from meta-analyses
Optimal duration of triple antithrombotic therapy balancing ischemic and bleeding risk
Long-term oral anticoagulants
Selection of the antiplatelet agent in addition to oral anticoagulants
European and American guidelines recommendations
Ongoing trials and registries
Summary
Clinics care points
Antithrombotic Therapy in Patients Undergoing Percutaneous Left Atrial Appendage Occlusion
Key points
Introduction
Antithrombotic therapy before and during left atrial appendage closure
Antithrombotic therapy after left atrial appendage closure
Summary
Clinics care points
Antithrombotic Therapy in Patients Undergoing Peripheral Artery Interventions
Key points
Introduction
Anticoagulation therapy
Dual antiplatelet therapy
Dual pathway inhibition therapy
Future directions
Summary
Clinics care points
Anticoagulant Therapy in Patients Undergoing Acute Pulmonary Embolism Interventions
Key points
Introduction
Catheter-based interventions
Surgical embolectomy
Mechanical circulatory support
Transition to oral anticoagulants
Special situations
Recommendations from professional societies
Future perspectives
Summary
Clinics care points
Supplementary data
Considerations in Antiplatelet Therapy in Women Undergoing Treatment of Acute Coronary Syndrome or Percutaneous Coronary Intervention
Key points
Introduction
Physiology
Bleeding risk
Thrombotic risk
Pharmacology
Aspirin
P2Y12 inhibitors
Glycoprotein IIb/IIIa inhibitors
Strategies to improve outcomes in women
Summary
Clinics care points

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Antiplatelet and Anticoagulation Therapy in Cardiovascular and Pulmonary Embolism Transcatheter Interventions, An Issue of Interventional Cardiology Clinics

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Luis Ortega Paz